YRC Public Data Repository - Protein Structure Prediction

Protein:	MPH1
Organism:	Saccharomyces cerevisiae
Length:	993 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPH1.

Description	E-value	Query Range	Subject Range
gi\|190406221 - gi\|190406221\|gb\|EDV09488.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] MPH1 - Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that in... MPH1_YEAST - ATP-dependent DNA helicase MPH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPH1 PE=...	0.0	[1..993]	[1..993]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[287..782]	[13..523]
PRP11_SCHPO - Pre-mRNA-processing ATP-dependent RNA helicase prp11 OS=Schizosaccharomyces pombe (strain 972 / ATCC... prp11 - ATP-dependent RNA helicase Prp11	0.0	[242..818]	[366..942]
gi\|5059030 - gi\|5059030\|gb\|AAD38876.1\|AF110008_1 p68 RNA helicase [Molgula occulta]	0.0	[246..654]	[102..534]
gi\|5059027, gi\|5... - gi\|5059032\|gb\|AAD38877.1\|AF110009_1 p68 RNA helicase [Molgula oculata], gi\|5059027\|gb\|AAD38874.1\|AF1...	0.0	[246..654]	[100..532]
DEAD_KLEPN - ATP-dependent RNA helicase DeaD OS=Klebsiella pneumoniae GN=deaD PE=3 SV=3	0.0	[296..782]	[6..507]
gi\|45382259, gi\|... - gi\|5114446\|gb\|AAD40318.1\|AF158370_1 DEAD-box RNA helicase [Gallus gallus], gi\|45382259\|ref\|NP_990158...	0.0	[249..647]	[38..459]
gi\|10177293 - gi\|10177293\|dbj\|BAB10554.1\| ATP-dependent RNA helicase-like protein [Arabidopsis thaliana]	0.0	[250..647]	[95..513]
gi\|5270 - gi\|5270\|emb\|CAA36873.1\| p68 protein [Schizosaccharomyces pombe]	0.0	[248..653]	[77..505]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASADDYFSD FEDDELDKLY EKAINKSVKE TITRRAVPVQ KDLHDNVLPG QKTVYEEIQR  60
   61 DVSFGPTHHE LDYDALSFYV YPTNYEVRDY QYTIVHKSLF QNTLCAIPTG MGKTFIASTV 120
  121 MLNYFRWTKK AKIIFTAPTR PLVAQQIKAC LGITGIPSDQ TAILLDKSRK NREEIWANKR 180
  181 VFFATPQVVE NDLKRGVLDP KDIVCLVIDE AHRATGSSAY TNVVKFIDRF NSSYRLLALT 240
  241 ATPASDLEGV QEVVNNLDIS KIEIRTEESM DIVKYMKKRK KEKIEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	68.69897
Match:	1qdeA_
Description:	Initiation factor 4a
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [287-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLLLEIEDII EQLGMAVKPV LQQAIELGIY EECDPSQINA FKAMQQSQKI IANPTIPEGI  60
   61 KWRNFFILQL LNNVGQMLKR LKIYGIRTFF NYFQNKCTEF TTKYNLKKST NKIAAEFYYH 120
  121 PILKNIKNQC ENYLSDPKFV GHGKLQCVRD ELMDFFQKRG SDSRVIIFTE LRESALEIVK 180
  181 FIDSVADDQI RPHIFIGQAR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	145.228787
Match:	1hv8A_
Description:	Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [487-634]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKEGFDEVKY TRKHAPKGRK KVERLHRQEQ EKFLEAERTK RAANDKLERS ARRTGSSEEA  60
   61 QISGMNQKMQ KEVIHNFKKG EYNVLVCTSI GEEGLDIGEV DLIICYDTTS SPIKNIQRMG 120
  121 RTGRKRDGKI VLLFSSNESY KFERAMED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	145.228787
Match:	1hv8A_
Description:	Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [635-737]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSTLQALISK QCIDYKKSDR IIPEDIIPEC HETLITINDE NEIINEMEDV DEVIRYATQC  60
   61 MMGKKVKPKK AITKKKRVQE NKKPKKFFMP DNVETSIVSA STL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.522879
Match:	1d9xA_
Description:	Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [738-993]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INKFLVNESG GKQLVTSNEN PSKKRKIFKA LDNLENDSTE EASSSLETED EEVSDDNNVF  60
   61 IAEGQNGCQK DLETAIIRTG ESLTTLKPLH NFERPNMALF VNDCGLPTKI EKNVKDIRGN 120
  121 QHNLEKEKSC TVDKNNMVLS LDDWNFFRNR YIPEGVSFDV EPNFVQYTKG VKVPHCHKVS 180
  181 KIITLFNDES NDNKKRTIDM NYTKCLARGM LRDEKKFVKV NDKSQVDNNS VNHDSSQSFT 240
  241 LSNAELDDIL GSDSDF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits