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View Structure Prediction Details

Protein: IMD2
Organism: Saccharomyces cerevisiae
Length: 523 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMD2.

Description E-value Query
Range		 Subject
Range
IMDH2_YEAST - Inosine-5'-monophosphate dehydrogenase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
IMD2 - Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expressio...
 0.0 [1..523] [1..523]
IMDH_CANAL - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=IMH3 P...
IMDH_CANAX - Inosine-5'-monophosphate dehydrogenase OS=Candida albicans GN=IMH3 PE=2 SV=1
 0.0 [7..523] [5..521]
IMPDH1 - IMP (inosine 5'-monophosphate) dehydrogenase 1
 0.0 [4..522] [1..514]
IMDH2_CRIGR - Inosine-5'-monophosphate dehydrogenase 2 OS=Cricetulus griseus GN=IMPDH2 PE=1 SV=1
 0.0 [4..522] [1..514]
gua1 - IMP dehydrogenase Gua1
IMDH_SCHPO - Inosine-5'-monophosphate dehydrogenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gua...
 0.0 [1..522] [1..524]
IMDH2_MOUSE - Inosine-5'-monophosphate dehydrogenase 2 OS=Mus musculus GN=Impdh2 PE=1 SV=2
 0.0 [4..522] [1..514]

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Predicted Domain #1
Region A:
Residues: [1-523] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAIRDYKTA LDFTKSLPRP DGLSVQELMD SKIRGGLTYN DFLILPGLVD FASSEVSLQT  60
   61 KLTRNITLNI PLVSSPMDTV TESEMATFMA LLGGIGFIHH NCTPEDQADM VRRVKNYENG 120
  121 FINNPIVISP TTTVGEAKSM KEKYGFAGFP VTTDGKRNAK LVGVITSRDI QFVEDNSLLV 180
  181 QDVMTKNPVT GAQGITLSEG NEILKKIKKG RLLVVDEKGN LVSMLSRTDL MKNQNYPLAS 240
  241 KSANTKQLLC GASIGTMDAD KERLRLLVKA GLDVVILDSS QGNSIFELNM LKWVKESFPG 300
  301 LEVIAGNVVT REQAANLIAA GADGLRIGMG TGSICITQEV MACGRPQGTA VYNVCEFANQ 360
  361 FGVPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES PGEYFYQDGK RLKAYRGMGS 420
  421 IDAMQKTGTK GNASTSRYFS ESDSVLVAQG VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG 480
  481 CRSLTLLKNN VQRGKVRFEF RTASAQLEGG VHNLHSYEKR LHN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1947.0
Match: 1b3oA_
Description: Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
IMP dehydrogenase activity 2.02048863053452 bayes_pls_golite062009
binding 0.964202692685807 bayes_pls_golite062009
transporter activity 0.961062314616209 bayes_pls_golite062009
transmembrane transporter activity 0.807029018941177 bayes_pls_golite062009
substrate-specific transporter activity 0.640881170978843 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.525366315833255 bayes_pls_golite062009
ion transmembrane transporter activity 0.440262824681055 bayes_pls_golite062009
protein binding 0.22179604283012 bayes_pls_golite062009
catalytic activity 0.181756622780318 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.0973526732376297 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle