YRC Public Data Repository - Protein Structure Prediction

Protein:	SPS100
Organism:	Saccharomyces cerevisiae
Length:	326 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPS100.

Description	E-value	Query Range	Subject Range
GATD_PYRFU - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 /... GATD_PYRFU - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus furiosus GN=gatD PE=3 SV=1	6.0E-89	[12..322]	[94..421]
GATD_PYRAB - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=gatD PE=1... GATD_PYRAB - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus abyssi GN=gatD PE=1 SV=1	1.0E-88	[13..321]	[95..419]
GATD_PYRHO - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 124... GATD_PYRHO - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Pyrococcus horikoshii GN=gatD PE=3 SV=1	5.0E-88	[13..321]	[95..419]
GATD_ARCFU - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Archaeoglobus fulgidus GN=gatD PE=3 SV=1 GATD_ARCFU - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 /...	4.0E-80	[14..320]	[85..403]
gi\|7451280, gi\|6... - gi\|7451280\|pir\|\|C69194 L-asparaginase I - Methanobacterium thermoautotrophicum (strain Delta H), gi... GATD_METTH - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Methanothermobacter thermautotrophicus (strain ATCC...	9.0E-80	[14..321]	[95..416]
gi\|668327 - gi\|668327\|gb\|AAA62276.1\| chimeric immunoglobulin-L-asparaginase [synthetic construct]	1.0E-79	[7..321]	[293..612]
GATD_SULTO - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 /... GATD_SULTO - Glutamyl-tRNA(Gln) amidotransferase subunit D OS=Sulfolobus tokodaii GN=gatD PE=3 SV=1	9.0E-79	[14..321]	[96..420]
ASPG_WOLSU - L-asparaginase OS=Wolinella succinogenes GN=ansA PE=1 SV=2 ASPG_WOLSU - L-asparaginase OS=Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC...	5.0E-78	[11..322]	[12..328]
gi\|632685 - gi\|632685\|gb\|AAB31750.1\| glutaminase-asparaginase, PGA=tetrameric bacterial amidohydrolase [Pseudomo...	1.0E-77	[11..321]	[18..334]
gi\|7435926 - pir\|\|D71904 asparaginase (EC 3.5.1.1) II [similarity] - Helicobacter pylori (strain J99) ASPG_HELPJ - Probable L-asparaginase OS=Helicobacter pylori (strain J99 / ATCC 700824) GN=ansA PE=1 SV=1	2.0E-77	[7..321]	[8..329]

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Predicted Domain #1

Region A:
Residues: [1-211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFTSVLAFF LATLTASATP LYKRQNVTSG GGTVPVIITG GPAVSGSQSN VTTTTLFNST  60
   61 STLNITQLYQ IATQVNQTLQ SESSSGIIIV TNWRSIETLS FFCSIVFNTS KTIVITENFL 120
  121 WGVPILSSSD AEGRGTLVAG RDKVVYSGVF PPYTVPVGVL SGQKNVQWFF DACEPTLIAS 180
  181 NSTIRTQYSN FTSAQISSNA SSGTNTSSSS S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.522879
Match:	1agx__
Description:	Glutaminase-asparaginase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.06115422930173	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	1.00776502581712	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [212-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLVPIIYEE GYSQSLIQSL SSSIQGLVVV SSGTSHNSTV ASWTSVDFPV VYASDGSSGH  60
   61 DGSGIGFISN TSIPQGAISA GYLSPIQAQT LLSIAIHNQV TSSSELQQIF PVSQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.522879
Match:	1agx__
Description:	Glutaminase-asparaginase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: