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View Structure Prediction Details

Protein: SMF2
Organism: Saccharomyces cerevisiae
Length: 549 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMF2.

Description E-value Query
Range
Subject
Range
gi|207344708 - gi|207344708|gb|EDZ71762.1| YHR050Wp-like protein [Saccharomyces cerevisiae AWRI1631]
SMF2 - Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valen...
gi|151943995 - gi|151943995|gb|EDN62288.1| suppressor of mitochondria import function [Saccharomyces cerevisiae YJM...
SMF2_YEAST - Manganese transporter SMF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMF2 PE=3 SV=...
0.0 [1..549] [1..549]
gi|4433391 - gi|4433391|gb|AAD20722.1| natural resistance associated macrophage protein-beta [Oncorhynchus mykiss...
0.0 [5..463] [11..466]
NRAM2_MOUSE - Natural resistance-associated macrophage protein 2 OS=Mus musculus GN=Slc11a2 PE=1 SV=2
0.0 [2..463] [15..472]
gi|149032038, gi... - gi|6981288|ref|NP_037305.1| solute carrier family 11 (proton-coupled divalent metal ion transporters...
0.0 [2..463] [15..472]
gi|57164361, gi|... - gi|57164361|ref|NP_001009345.1| natural resistance associated macrophage protein [Ovis aries], gi|40...
0.0 [1..463] [24..481]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSQEYEPIQ WSDESQTNND SVNDAYADVN TTHESRRRTT LQPNSTSQSM IGTLRKYARF  60
   61 IGPGLMVSVS YMDPG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.418 d.58.7 RNA-binding domain, RBD
View Download 0.507 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.524 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.478 a.46.1 Methionine synthase domain
View Download 0.458 g.2.2 Neurotoxin B-IV
View Download 0.389 a.4.5 "Winged helix" DNA-binding domain
View Download 0.380 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.372 a.64.2 Bacteriocin AS-48
View Download 0.368 d.58.17 Metal-binding domain
View Download 0.356 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.320 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.310 a.3.1 Cytochrome c
View Download 0.309 a.2.7 tRNA-binding arm
View Download 0.307 d.52.1 Alpha-lytic protease prodomain
View Download 0.307 a.30.1 ROP protein
View Download 0.306 d.58.48 MTH1187-like
View Download 0.276 f.17.1 F1F0 ATP synthase subunit C
View Download 0.275 a.40.1 Calponin-homology domain, CH-domain
View Download 0.263 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.259 d.58.4 Dimeric alpha+beta barrel
View Download 0.258 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.255 d.58.24 CheY-binding domain of CheA
View Download 0.253 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.249 a.2.7 tRNA-binding arm
View Download 0.246 f.13.1 Family A G protein-coupled receptor-like
View Download 0.246 a.65.1 Annexin
View Download 0.244 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.240 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.236 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.232 d.58.49 YajQ-like
View Download 0.230 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.229 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.229 a.144.1 PABC (PABP) domain
View Download 0.222 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.221 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.220 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.219 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.219 a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.216 d.58.5 GlnB-like
View Download 0.215 a.112.1 Description not found.
View Download 0.214 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.213 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.209 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.204 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.202 f.17.1 F1F0 ATP synthase subunit C
View Download 0.201 a.4.1 Homeodomain-like
View Download 0.201 a.118.8 TPR-like

Predicted Domain #2
Region A:
Residues: [76-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYSTAVAAGS AHRYKLLFSV LVSNFMAAFW QYLCARLGAV TGLDLAQNCK KHLPFGLNIT  60
   61 LYILAEMAII ATDLAEVVGT AISLNILFHI PLALGVILTV VDVLIVLLAY KPNGSMKGIR 120
  121 IFEAFVSLLV VLTVVCFTVE LFYAKLGPAK EIFSGFLPSK AVFEGDGLYL SLAILGATVM 180
  181 PHSLYLGSGV VQPRLREYDI KNGHYLPDAN DMDNNHDNYR PSYEAISETL HFTITELLIS 240
  241 LFTVALFVNC AILIVSGATL YGSTQNAEEA DLFSIYNLLC STLSKGAGTV FVLALLFSGQ 300
  301 SAGIVCTLSG QMVSEGFLNW TVSPALRRSA TRAVAITPCL ILVLVAGRSG LSGALNASQV 360
  361 VLSLLLPFVS APLLYFTSSK KIMRVQLNRT KELSRTTDKK PVADRTEDDE TIELEEMGIG 420
  421 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 242.886057
Match: PF01566
Description: Natural resistance-associated macrophage protein

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [496-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSQERSLVS PAPEYKDMSN GMIVTVLAII VWLIISGLNF YMLLGFTTGK EVHL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.508 a.4.1 Homeodomain-like
View Download 0.358 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.334 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.295 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.270 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.267 a.4.5 "Winged helix" DNA-binding domain
View Download 0.217 a.5.6 Hypothetical protein MTH1615
View Download 0.207 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.204 d.15.7 Immunoglobulin-binding domains


YRC Informatics Platform - Version 3.0
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