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View Structure Prediction Details

Protein: YHR045W
Organism: Saccharomyces cerevisiae
Length: 560 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHR045W.

Description E-value Query
Range
Subject
Range
YHK5_YEAST - Putative uncharacterized protein YHR045W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
YHR045W - Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohy...
0.0 [1..560] [1..560]

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Predicted Domain #1
Region A:
Residues: [1-560]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNWSFLLQLV ITILLIVLGA NWLLSSFLLD FKRDLTGVAL SQQSSISSVR KENETAYYRS  60
   61 ILVPTGFPLT TGLGLSLKYK IRNGNFGDVW NAIMEVSKGK NIIKFTGREK SYSLSELNGM 120
  121 AKRIFPKLSN KNFKNIGIAN SIATVEGFTL SLASMMTSIR TGSIPHFLPA VPRQRLEDVD 180
  181 VLIIDSWKSF KMLNGSEDWY KLIVVCDDPI ESLQFDANCD VITWKELIDG FTKDTEYQYT 240
  241 PPDDNSDDKK LFAYVTSPWN GTNSFNQICL VSNIAEFIKG FPLGNELNSN EYLTISTKLA 300
  301 NSSASLQIWG KLFAVLLHGG SASFINPTTI DCESLQETTL LFTETKDVVK LIDSNSRSGL 360
  361 LNKIYLSWAT NLLSEGIFTK IARIEPHSLE KLRCVYLADN VKDAEVISTF PEKIPQLKKT 420
  421 NRRITPSTEQ LNKIRAQLGS RVVLELYCPY AIMGPVAHTN FYDYRVFGKS VDDNVVCYGT 480
  481 LSTTLEGKMV ETETNPHLNI EKKQGMLCIR GFSIGKPVES DRLEKALHLA ERFGGGEGWM 540
  541 PLVGVFGLFG QDGCLYIYNQ 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-560]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNAIMEVSKG KNIIKFTGRE KSYSLSELNG MAKRIFPKLS NKNFKNIGIA NSIATVEGFT  60
   61 LSLASMMTSI RTGSIPHFLP AVPRQRLEDV DVLIIDSWKS FKMLNGSEDW YKLIVVCDDP 120
  121 IESLQFDANC DVITWKELID GFTKDTEYQY TPPDDNSDDK KLFAYVTSPW NGTNSFNQIC 180
  181 LVSNIAEFIK GFPLGNELNS NEYLTISTKL ANSSASLQIW GKLFAVLLHG GSASFINPTT 240
  241 IDCESLQETT LLFTETKDVV KLIDSNSRSG LLNKIYLSWA TNLLSEGIFT KIARIEPHSL 300
  301 EKLRCVYLAD NVKDAEVIST FPEKIPQLKK TNRRITPSTE QLNKIRAQLG SRVVLELYCP 360
  361 YAIMGPVAHT NFYDYRVFGK SVDDNVVCYG TLSTTLEGKM VETETNPHLN IEKKQGMLCI 420
  421 RGFSIGKPVE SDRLEKALHL AERFGGGEGW MPLVGVFGLF GQDGCLYIYN Q

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.68
Match: 1t5dX
Description: 4-Chlorobenzoyl-CoA Ligase/Synthetase bound to 4-chlorobenzoate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity 4.06242055385309 bayes_pls_golite062009
catalytic activity 1.69360998653645 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 0.628869837876574 bayes_pls_golite062009
transcription regulator activity 0.618855673590647 bayes_pls_golite062009
fatty acid ligase activity 0.601319691359111 bayes_pls_golite062009
binding 0.556684584703993 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 0.512215883711737 bayes_pls_golite062009
adenyl ribonucleotide binding 0.196112501848345 bayes_pls_golite062009
adenyl nucleotide binding 0.180363467988742 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle