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View Structure Prediction Details

Protein: YHR035W
Organism: Saccharomyces cerevisiae
Length: 630 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHR035W.

Description E-value Query
Range
Subject
Range
gi|7271162 - gi|7271162|emb|CAB81549.1| putative Sec23 protein [Drosophila melanogaster]
0.0 [1..629] [34..766]
SEC23B - Sec23 homolog B (S. cerevisiae)
0.0 [1..629] [34..764]
gi|13365827 - gi|13365827|dbj|BAB39299.1| hypothetical protein [Macaca fascicularis]
0.0 [1..629] [34..764]
SC23B_MOUSE - Protein transport protein Sec23B OS=Mus musculus GN=Sec23b PE=1 SV=1
gi|126035610 - gi|126035610|gb|ABN72531.1| SEC23B [Mus spretus]
0.0 [1..629] [34..764]
SEC23_NEUCR - Protein transport protein sec-23 OS=Neurospora crassa GN=sec-23 PE=3 SV=1
SEC23_NEUCR - Protein transport protein sec23 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / ...
0.0 [1..629] [36..772]
gi|15229489, gi|... - gi|9294523|dbj|BAB02785.1| protein transport protein Sec23 [Arabidopsis thaliana], gi|28827624|gb|AA...
0.0 [2..628] [33..763]
sec-23 - status:Confirmed UniProt:Q9U2Z1 protein_id:CAB60476.2
0.0 [1..622] [34..811]

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Predicted Domain #1
Region A:
Residues: [1-56]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCSPTNFLYE PFSSDAVTQN YDQNLKCTKC GAYYSMACSL REQNVWTCLF CNQSNS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.591 N/A N/A b.122.1 PUA domain-like
View Download 0.556 N/A N/A b.49.1 N-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.483 N/A N/A g.18.1 Complement control module/SCR domain
View Download 0.402 N/A N/A g.27.1 Fibronectin type I module
View Download 0.401 N/A N/A d.9.2 Description not found.
View Download 0.373 N/A N/A g.41.3 Zinc beta-ribbon
View Download 0.366 N/A N/A g.18.1 Complement control module/SCR domain
View Download 0.351 N/A N/A g.41.3 Zinc beta-ribbon
View Download 0.345 N/A N/A g.27.1 Fibronectin type I module
View Download 0.329 N/A N/A g.18.1 Complement control module/SCR domain
View Download 0.328 N/A N/A g.3.7 Scorpion toxin-like
View Download 0.308 N/A N/A d.11.1 Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View Download 0.305 N/A N/A d.9.1 Interleukin 8-like chemokines
View Download 0.285 N/A N/A g.20.1 Blood coagulation inhibitor (disintegrin)
View Download 0.281 N/A N/A g.27.1 Fibronectin type I module
View Download 0.277 N/A N/A d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.276 N/A N/A g.18.1 Complement control module/SCR domain
View Download 0.260 N/A N/A b.84.2 Rudiment single hybrid motif
View Download 0.250 N/A N/A d.9.2 Description not found.
View Download 0.247 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.242 N/A N/A d.40.1 CI-2 family of serine protease inhibitors
View Download 0.229 N/A N/A d.40.1 CI-2 family of serine protease inhibitors
View Download 0.223 N/A N/A d.50.1 dsRNA-binding domain-like
View Download 0.220 N/A N/A b.1.3 PKD domain
View Download 0.203 N/A N/A d.17.5 Uracil-DNA glycosylase inhibitor protein

Predicted Domain #2
Region A:
Residues: [57-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAELPLVPSN TYTLTSAKKE ILSRRTIMII DAICDPHELN YLVSILCNNY ITRQQEPLSI  60
   61 ITIQQSGHVI LHNAVNHRRD AVF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.778 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.630 d.68.3 SirA-like
View Download 0.587 d.52.1 Alpha-lytic protease prodomain
View Download 0.566 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.545 d.95.2 Homing endonucleases
View Download 0.545 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.538 d.95.2 Homing endonucleases
View Download 0.507 d.68.7 R3H domain
View Download 0.469 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.468 d.45.1 ClpS-like
View Download 0.466 d.68.3 SirA-like
View Download 0.456 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.448 c.5.1 MurCD N-terminal domain
View Download 0.447 d.79.3 L30e-like
View Download 0.446 d.74.2 C-terminal domain of arginine repressor
View Download 0.445 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.431 d.68.5 C-terminal domain of ProRS
View Download 0.430 c.78.2 Aspartate/glutamate racemase
View Download 0.417 d.206.1 YggU-like
View Download 0.413 d.109.1 Actin depolymerizing proteins
View Download 0.412 d.206.1 YggU-like
View Download 0.409 a.4.5 "Winged helix" DNA-binding domain
View Download 0.403 c.51.3 B12-dependend dehydatases associated subunit
View Download 0.403 a.65.1 Annexin
View Download 0.401 g.7.1 Snake toxin-like
View Download 0.393 d.15.7 Immunoglobulin-binding domains
View Download 0.358 c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.349 b.1.2 Fibronectin type III
View Download 0.342 d.40.1 CI-2 family of serine protease inhibitors
View Download 0.331 d.74.5 Hypothetical protein Yml108w
View Download 0.323 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.320 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.319 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.319 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.318 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.312 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.312 a.4.1 Homeodomain-like
View Download 0.311 d.68.4 YhbY-like
View Download 0.310 c.54.1 IIA domain of mannose transporter, IIA-Man
View Download 0.302 d.110.4 SNARE-like
View Download 0.297 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.293 a.40.1 Calponin-homology domain, CH-domain
View Download 0.287 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.281 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.281 a.118.11 Cytochrome c oxidase subunit E
View Download 0.281 d.237.1 Hypothetical protein YjiA, C-terminal domain
View Download 0.280 d.58.7 RNA-binding domain, RBD
View Download 0.279 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.278 d.40.1 CI-2 family of serine protease inhibitors
View Download 0.272 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.265 d.26.1 FKBP-like
View Download 0.255 d.88.1 SRF-like
View Download 0.251 d.15.6 Superantigen toxins, C-terminal domain
View Download 0.249 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.247 a.118.8 TPR-like
View Download 0.247 b.1.18 E set domains
View Download 0.240 a.16.1 S15/NS1 RNA-binding domain
View Download 0.237 f.14.1 Voltage-gated potassium channels
View Download 0.236 d.13.1 HIT-like
View Download 0.223 b.40.2 Bacterial enterotoxins
View Download 0.222 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.221 d.109.1 Actin depolymerizing proteins
View Download 0.213 c.95.1 Thiolase-like
View Download 0.213 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.211 d.95.2 Homing endonucleases
View Download 0.209 b.85.4 dUTPase-like
View Download 0.208 d.58.7 RNA-binding domain, RBD
View Download 0.205 d.58.48 MTH1187-like
View Download 0.202 d.131.1 DNA clamp

Predicted Domain #3
Region A:
Residues: [140-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SINEFMTKYN LDKLNASYFE KKISEINQES YWFDKSTQGS LRKLLREICK IANKVNISSK  60
   61 RDKRCTGLAL FVSSVLASQC SLSAYCHIVS FLNGPCTKGG GKVMSRERGE SMRQNHHFES 120
  121 KSSQLQLSKS PTKFYKKMLE KFANQSLIYE FFIASLDQIG ILEMSPLITS SMAVSQFDSF 180
  181 NDERFAMSFQ KYLNLRDHNA IYNCHSKIMT AKNAIVVKDF PKYSLNPKNL SLPLEISLGH 240
  241 NSAEAPIQFQ TTFENQTEKY IRIETLLLPK ANRSFGAQNE IVFSMKKIAS RIIDSFAYSS 300
  301 KHTKELMKQL FLLPNQIRGK DVDMVNLIQW CYHIYRSPIL SV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [482-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNTSPDERYL FLHRIINASK DTCLSLCKPF IWSYSDLKHD WIVLDVPLTR AQILQDDKTT  60
   61 ICVDGGSYLV LRRGKLLEKE GRELCCKLLN DLQRFPQPLY VETKTGGSQD RFLKSKIIPL 120
  121 DITDKETLGT EDMTFNEYFN LFTDLSGSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1svy__
Description: Severin, domain 2
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle