YRC Public Data Repository - Protein Structure Prediction

Protein:	DED81
Organism:	Saccharomyces cerevisiae
Length:	554 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DED81.

Description	E-value	Query Range	Subject Range
gi\|190405803 - gi\|190405803\|gb\|EDV09070.1\| asparaginyl-tRNA synthetase [Saccharomyces cerevisiae RM11-1a] DED81 - Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attach... SYNC_YEAST - Asparagine--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DED... gi\|151943961 - gi\|151943961\|gb\|EDN62254.1\| asparaginyl-tRNA synthetase [Saccharomyces cerevisiae YJM789]	0.0	[1..554]	[1..554]
NARS - asparaginyl-tRNA synthetase	0.0	[1..554]	[3..548]
gi\|220953642, gi... - gi\|220953642\|gb\|ACL89364.1\| Aats-asn-PA [synthetic construct], gi\|220943736\|gb\|ACL84411.1\| Aats-asn-... Aats-asn-PA, FBp... - The gene Asparaginyl-tRNA synthetase is referred to in FlyBase by the symbol Dmel\Aats-asn (CG10687,...	0.0	[1..554]	[11..558]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[3..554]	[2..548]
SYNC_BRUMA - Asparagine--tRNA ligase, cytoplasmic OS=Brugia malayi PE=1 SV=1	0.0	[3..554]	[2..548]
SYNC_SCHPO - Probable asparagine--tRNA ligase, cytoplasmic OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)... SPBC1773.10c - asparagine-tRNA ligase Ded81	0.0	[5..554]	[20..568]
gi\|221321410 - gi\|221321410\|ref\|ZP_03602704.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. SMY] gi\|221317147 - gi\|221317147\|ref\|ZP_03598441.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. JH642] gi\|221312214 - gi\|221312214\|ref\|ZP_03594019.1\| lysyl-tRNA synthetase [Bacillus subtilis subsp. subtilis str. NCIB 3... SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis (strain 168) GN=lysS PE=3 SV=1 SYK_BACSU - Lysine--tRNA ligase OS=Bacillus subtilis GN=lysS PE=3 SV=1	0.0	[78..551]	[8..499]
gi\|126943674, gi... - gi\|254899407\|ref\|ZP_05259331.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes J0161], gi\|15318... gi\|254831503, gi... - gi\|254831503\|ref\|ZP_05236158.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes 10403S], gi\|1531... SYN_LISMO - Asparagine--tRNA ligase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=asnS... gi\|254912454, gi... - gi\|254912454\|ref\|ZP_05262466.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes J2818], gi\|15319... gi\|284802341\|ref... - asparaginyl-tRNA synthetase [Listeria monocytogenes 08-5578] gi\|153175124, gi... - gi\|254827219\|ref\|ZP_05231906.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes FSL N3-165], gi\|... gi\|153179957, gi... - gi\|254936781\|ref\|ZP_05268478.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes F6900], gi\|15317... gi\|47096479, gi\|... - gi\|47096479\|ref\|ZP_00234071.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes str. 1/2a F6854],... gi\|224500248 - gi\|224500248\|ref\|ZP_03668597.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes Finland 1988] gi\|284995483\|ref... - asparaginyl-tRNA synthetase [Listeria monocytogenes 08-5923] SYN_LISMO - Asparagine--tRNA ligase OS=Listeria monocytogenes GN=asnS PE=3 SV=1 gi\|224501304 - gi\|224501304\|ref\|ZP_03669611.1\| asparaginyl-tRNA synthetase [Listeria monocytogenes FSL R2-561]	0.0	[117..554]	[1..430]
SYN_LISIN - Asparagine--tRNA ligase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=asnS PE=3 SV=1 SYN_LISIN - Asparagine--tRNA ligase OS=Listeria innocua GN=asnS PE=3 SV=1	0.0	[117..554]	[1..430]

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Predicted Domain #1

Region A:
Residues: [1-104]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYIKEAT GVDELTTAGS QDHPFKTPAY ALFASQQKSD ATEPKLFVFK TEDNEYQEIS  60
   61 ASALKKARKG CDGLKKKAVK QKEQELKKQQ KEAENAAKQL SALN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [105-226]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITIKEDESLP AAIKTRIYDS YSKVGQRVKV SGWIHRLRSN KKVIFVVLRD GSGFIQCVLS  60
   61 GDLALAQQTL DLTLESTVTL YGTIVKLPEG KTAPGGVELN VDYYEVVGLA PGGEDSFTNK 120
  121 IA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	611.9897
Match:	1b8aA_
Description:	Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [227-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSDPSLLLD QRHLALRGDA LSAVMKVRAA LLKSVRRVYD EEHLTEVTPP CMVQTQVEGG  60
   61 STLFKMNYYG EEAYLTQSSQ LYLETCLASL GDVYTIQESF RAEKSHTRRH LSEYTHIEAE 120
  121 LAFLTFDDLL QHIETLIVKS VQYVLEDPIA GPLVKQLNPN FKAPKAPFMR LQYKDAITWL 180
  181 NEHDIKNEEG EDFKFGDDIA EAAERKMTDT IGVPIFLTRF PVEIKSFYMK RCSDDPRVTE 240
  241 SVDVLMPNVG EITGGSMRID DMDELMAGFK REGIDTDAYY WFIDQRKYGT CPHGGYGIGT 300
  301 ERILAWLCDR FTVRDCSLYP RFSGRCKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	611.9897
Match:	1b8aA_
Description:	Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits