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View Structure Prediction Details

Protein: SPO11
Organism: Saccharomyces cerevisiae
Length: 398 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPO11.

Description E-value Query
Range
Subject
Range
SPO11 - Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-...
gi|151944178 - gi|151944178|gb|EDN62470.1| endodeoxyribonuclease [Saccharomyces cerevisiae YJM789]
SPO11_YEAST - Meiosis-specific protein SPO11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPO11 PE=...
0.0 [1..398] [1..398]
SPO11 - SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
0.0 [35..390] [36..373]
gi|162318682 - gi|162318682|gb|AAI56814.1| Sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae) [sy...
SPO11_MOUSE - Meiotic recombination protein SPO11 OS=Mus musculus GN=Spo11 PE=1 SV=2
0.0 [41..397] [43..380]
SPO11_ARATH - Meiotic recombination protein SPO11-1 OS=Arabidopsis thaliana GN=SPO11-1 PE=1 SV=1
2.0E-99 [42..397] [10..345]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALEGLRKKY KTRQELVKAL TPKRRSIHLN SNGHSNGTPC SNADVLAHIK HFLSLAANSL  60
   61 EQHQQPISIV FQNKKKKGDT SSPDIHTTLD FPLNG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [96-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHLCTHQFKL KRCAILLNLL KVVMEKLPLG KNTTVRDIFY SNVELFQRQA NVVQWLDVIR  60
   61 FNFKLSPRKS LNIIP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [171-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQKGLVYSPF PIDIYDNILT CENEPKMQKQ TIFPGKPCLI PFFQDDAVIK LGTTSMCNIV  60
   61 IVEKEAVFTK LVNNYHKLST NTMLITGKGF PDFLTRLFLK KLEQYCSKLI SDCSI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [298-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYTHSNERN AYICTMANYK GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [286-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTDADPYGIS IA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [320-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RITQVLAQNN EVHNKSIQLL SLNQRDYSLA KNLIASLTAN SWDIATSPLK NVIIECQREI  60
   61 FFQKKAEMNE IDARIFEYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1d3yA_
Description: DNA topoisomerase IV, alpha subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle