Protein: | BIO2 |
Organism: | Saccharomyces cerevisiae |
Length: | 375 amino acids |
Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIO2.
Description | E-value | Query Range |
Subject Range |
|
9.0E-94 | [1..375] | [1..375] |
|
7.0E-83 | [49..368] | [3..314] |
|
2.0E-82 | [49..368] | [3..314] |
|
4.0E-82 | [51..370] | [5..316] |
|
7.0E-82 | [50..370] | [4..316] |
|
7.0E-82 | [50..370] | [4..316] |
|
1.0E-81 | [50..370] | [4..316] |
|
1.0E-81 | [50..368] | [4..314] |
|
2.0E-81 | [50..370] | [4..316] |
|
2.0E-81 | [50..370] | [4..316] |
Region A: Residues: [1-116] |
1 11 21 31 41 51 | | | | | | 1 MMSTIYRHLS TARPALTKYA TNAAVKSTTA SSEASTLGAL QYALSLDEPS HSWTKSQLKE 60 61 IYHTPLLELT HAAQLQHRKW HDPTKVQLCT LMNIKSGGCS EDCKYCAQSS RNDTGL |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
MCM Score |
SCOP Match |
SCOP Description | ||
View | Download | 0.378 | c.23.5 | Flavoproteins |
View | Download | 0.657 | a.40.1 | Calponin-homology domain, CH-domain |
View | Download | 0.310 | a.6.1 | Putative DNA-binding domain |
View | Download | 0.441 | a.40.1 | Calponin-homology domain, CH-domain |
View | Download | 0.349 | c.23.5 | Flavoproteins |
View | Download | 0.265 | c.59.1 | MurD-like peptide ligases, peptide-binding domain |
View | Download | 0.254 | a.77.1 | DEATH domain |
View | Download | 0.240 | d.79.5 | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF |
View | Download | 0.224 | a.28.1 | ACP-like |
View | Download | 0.223 | d.15.1 | Ubiquitin-like |
View | Download | 0.222 | a.3.1 | Cytochrome c |
View | Download | 0.213 | c.95.1 | Thiolase-like |
View | Download | 0.209 | a.39.1 | EF-hand |
View | Download | 0.205 | a.74.1 | Cyclin-like |
Term | Confidence | Notes |
biotin synthase activity | 4.96431653338581 | bayes_pls_golite062009 |
radical SAM enzyme activity | 4.81217611621334 | bayes_pls_golite062009 |
sulfurtransferase activity | 3.43375708969779 | bayes_pls_golite062009 |
transferase activity, transferring sulfur-containing groups | 2.79703059227143 | bayes_pls_golite062009 |
coproporphyrinogen oxidase activity | 1.98937742831419 | bayes_pls_golite062009 |
catalytic activity | 1.48331922124015 | bayes_pls_golite062009 |
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor | 1.37188743230327 | bayes_pls_golite062009 |
binding | 1.19681284943457 | bayes_pls_golite062009 |
oxidoreductase activity, acting on the CH-CH group of donors | 1.18901545014659 | bayes_pls_golite062009 |
transferase activity | 0.685192555939835 | bayes_pls_golite062009 |
oxidoreductase activity | 0.593156857804038 | bayes_pls_golite062009 |
protein binding | 0.374124957429525 | bayes_pls_golite062009 |
Region A: Residues: [117-262] |
1 11 21 31 41 51 | | | | | | 1 KAEKMVKVDE VIKEAEEAKR NGSTRFCLGA AWRDMKGRKS AMKRIQEMVT KVNDMGLETC 60 61 VTLGMVDQDQ AKQLKDAGLT AYNHNIDTSR EHYSKVITTR TYDDRLQTIK NVQESGIKAC 120 121 TGGILGLGES EDDHIGFIYT LSNMSP |
Detection Method: | |
Confidence: | 2.522879 |
Match: | 1b5tA_ |
Description: | Methylenetetrahydrofolate reductase |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [263-375] |
1 11 21 31 41 51 | | | | | | 1 HPESLPINRL VAIKGTPMAE ELADPKSKKL QFDEILRTIA TARIVMPKAI IRLAAGRYTM 60 61 KETEQFVCFM AGCNSIFTGK KMLTTMCNGW DEDKAMLAKW GLQPMEAFKY DRS |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
View | Download | 0.537 | 0.092 | biotin biosynthetic process | c.61.1 | PRTase-like |
View | Download | 0.564 | 0.077 | biotin biosynthetic process | c.36.1 | Thiamin diphosphate-binding fold (THDP-binding) |
View | Download | 0.628 | 0.031 | biotin biosynthetic process | c.59.1 | MurD-like peptide ligases, peptide-binding domain |
View | Download | 0.548 | 0.008 | biotin biosynthetic process | d.68.4 | YhbY-like |
View | Download | 0.552 | N/A | N/A | c.25.1 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
View | Download | 0.496 | N/A | N/A | d.68.3 | SirA-like |
View | Download | 0.469 | N/A | N/A | c.3.1 | FAD/NAD(P)-binding domain |
View | Download | 0.469 | N/A | N/A | c.23.1 | CheY-like |
View | Download | 0.460 | N/A | N/A | c.10.2 | L domain-like |
View | Download | 0.431 | N/A | N/A | c.20.1 | Initiation factor IF2/eIF5b, domain 3 |
View | Download | 0.431 | N/A | N/A | c.10.1 | RNI-like |
View | Download | 0.420 | N/A | N/A | c.23.1 | CheY-like |
View | Download | 0.419 | N/A | N/A | c.25.1 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
View | Download | 0.410 | N/A | N/A | c.55.3 | Ribonuclease H-like |
View | Download | 0.396 | N/A | N/A | c.23.6 | Cobalamin (vitamin B12)-binding domain |
View | Download | 0.385 | N/A | N/A | c.25.1 | Ferredoxin reductase-like, C-terminal NADP-linked domain |
View | Download | 0.385 | N/A | N/A | d.68.3 | SirA-like |
View | Download | 0.379 | N/A | N/A | c.23.6 | Cobalamin (vitamin B12)-binding domain |
View | Download | 0.377 | N/A | N/A | c.55.3 | Ribonuclease H-like |
View | Download | 0.369 | N/A | N/A | c.1.2 | Ribulose-phoshate binding barrel |
View | Download | 0.345 | N/A | N/A | c.116.1 | alpha/beta knot |
View | Download | 0.343 | N/A | N/A | c.47.1 | Thioredoxin-like |
View | Download | 0.342 | N/A | N/A | c.23.1 | CheY-like |
View | Download | 0.340 | N/A | N/A | c.1.10 | Aldolase |
View | Download | 0.335 | N/A | N/A | c.59.1 | MurD-like peptide ligases, peptide-binding domain |
View | Download | 0.331 | N/A | N/A | c.3.1 | FAD/NAD(P)-binding domain |
View | Download | 0.322 | N/A | N/A | c.45.1 | (Phosphotyrosine protein) phosphatases II |
View | Download | 0.313 | N/A | N/A | c.1.11 | Enolase C-terminal domain-like |
View | Download | 0.307 | N/A | N/A | c.23.1 | CheY-like |
View | Download | 0.306 | N/A | N/A | b.80.3 | Cell-division inhibitor MinC, C-terminal domain |
View | Download | 0.287 | N/A | N/A | a.26.1 | 4-helical cytokines |
View | Download | 0.286 | N/A | N/A | c.36.1 | Thiamin diphosphate-binding fold (THDP-binding) |
View | Download | 0.284 | N/A | N/A | c.10.1 | RNI-like |
View | Download | 0.275 | N/A | N/A | c.52.1 | Restriction endonuclease-like |
View | Download | 0.268 | N/A | N/A | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
View | Download | 0.266 | N/A | N/A | c.26.2 | Adenine nucleotide alpha hydrolases-like |
View | Download | 0.256 | N/A | N/A | c.1.11 | Enolase C-terminal domain-like |
View | Download | 0.254 | N/A | N/A | a.118.1 | ARM repeat |
View | Download | 0.246 | N/A | N/A | c.1.10 | Aldolase |
View | Download | 0.246 | N/A | N/A | c.2.1 | NAD(P)-binding Rossmann-fold domains |
View | Download | 0.240 | N/A | N/A | c.62.1 | vWA-like |
View | Download | 0.228 | N/A | N/A | d.41.4 | Ribosomal protein L10e |
View | Download | 0.206 | N/A | N/A | c.54.1 | IIA domain of mannose transporter, IIA-Man |
View | Download | 0.204 | N/A | N/A | c.2.1 | NAD(P)-binding Rossmann-fold domains |
View | Download | 0.203 | N/A | N/A | d.79.1 | YjgF-like |
View | Download | 0.201 | N/A | N/A | c.23.4 | Succinyl-CoA synthetase domains |
View | Download | 0.201 | N/A | N/A | a.118.8 | TPR-like |