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View Structure Prediction Details

Protein: TPO2
Organism: Saccharomyces cerevisiae
Length: 614 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPO2.

Description E-value Query
Range
Subject
Range
gi|151943417 - gi|151943417|gb|EDN61728.1| Transporter of polyamines [Saccharomyces cerevisiae YJM789]
TPO2_YEAST - Polyamine transporter 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO2 PE=1 SV=1
gi|207345075 - gi|207345075|gb|EDZ72014.1| YGR138Cp-like protein [Saccharomyces cerevisiae AWRI1631]
TPO2 - Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription o...
0.0 [1..614] [1..614]
gi|9801985, gi|7... - gi|9801985|gb|AAF99573.1|AF188621_1 fluconazole resistance protein [Candida albicans], gi|76573588|d...
gi|68469252, gi|... - gi|77022662|ref|XP_888775.1| hypothetical protein CaO19_6577 [Candida albicans SC5314], gi|68470277|...
2.0E-99 [54..610] [50..610]
SPBC36.01c - spermidine family transporter
YN41_SCHPO - Uncharacterized transporter C36.01c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC36...
1.0E-97 [46..603] [9..575]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQESVVSF NSQNTSMVDV EGQQPQQYVP SKTNSRANQL KLTKTETVKS LQDLGVTSAA  60
   61 PVPDINAPQT AKNNIFPEEY TMETPSGLVP VATLQSMGRT ASALSRTRTK QLNRTATNSS 120
  121 STGKEEMEEE ETEEREDQSG ENELDPE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.244 0.131 vacuolar membrane c.26.1 Nucleotidylyl transferase

Predicted Domain #2
Region A:
Residues: [148-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEFVTFVTGD PENPHNWPSW VRWSYTVLLS ILVICVAYGS ACISGGLGTV EKKYHVGMEA  60
   61 AILSCSLMVI GFSLGPLIWS PVSDLYGRRV AYFVSMGLYV IFNIPCALAP NLGCLLACRF 120
  121 LCGVWSSSGL CLVGGSIADM FPSETRGKAI AFFAFAPYVG PVVGPLVNGF ISVSTGRMDL 180
  181 IFWVNMAFAG VMWIISSAIP 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [389-614]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLLRPLYFAV TEPVLVATCF YVCLIYSLLY AFFFAFPVIF GELYGYKDNL VGLMFIPIVI  60
   61 GALWALATTF YCENKYLQIV KQRKPTPEDR LLGAKIGAPF AAIALWILGA TAYKHIIWVG 120
  121 PASAGLAFGF GMVLIYYSLN NYIIDCYVQY ASSALATKVF LRSAGGAAFP LFTIQMYHKL 180
  181 NLHWGSWLLA FISTAMIALP FAFSYWGKGL RHKLSKKDYS IDSVEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.24937104052238 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
binding 1.01584233411372 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [348-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETYAPVILKR KAARLRKETG NPKIMTEQEA QGVSMSEMMR A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle