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View Structure Prediction Details

Protein: TPO2
Organism: Saccharomyces cerevisiae
Length: 614 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPO2.

Description E-value Query
Range
Subject
Range
gi|151943417 - gi|151943417|gb|EDN61728.1| Transporter of polyamines [Saccharomyces cerevisiae YJM789]
TPO2_YEAST - Polyamine transporter 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO2 PE=1 SV=1
gi|207345075 - gi|207345075|gb|EDZ72014.1| YGR138Cp-like protein [Saccharomyces cerevisiae AWRI1631]
TPO2 - Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription o...
0.0 [1..614] [1..614]
gi|9801985, gi|7... - gi|9801985|gb|AAF99573.1|AF188621_1 fluconazole resistance protein [Candida albicans], gi|76573588|d...
gi|68469252, gi|... - gi|77022662|ref|XP_888775.1| hypothetical protein CaO19_6577 [Candida albicans SC5314], gi|68470277|...
2.0E-99 [54..610] [50..610]
SPBC36.01c - spermidine family transporter
YN41_SCHPO - Uncharacterized transporter C36.01c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC36...
1.0E-97 [46..603] [9..575]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQESVVSF NSQNTSMVDV EGQQPQQYVP SKTNSRANQL KLTKTETVKS LQDLGVTSAA  60
   61 PVPDINAPQT AKNNIFPEEY TMETPSGLVP VATLQSMGRT ASALSRTRTK QLNRTATNSS 120
  121 STGKEEMEEE ETEEREDQSG ENELDPE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [148-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEFVTFVTGD PENPHNWPSW VRWSYTVLLS ILVICVAYGS ACISGGLGTV EKKYHVGMEA  60
   61 AILSCSLMVI GFSLGPLIWS PVSDLYGRRV AYFVSMGLYV IFNIPCALAP NLGCLLACRF 120
  121 LCGVWSSSGL CLVGGSIADM FPSETRGKAI AFFAFAPYVG PVVGPLVNGF ISVSTGRMDL 180
  181 IFWVNMAFAG VMWIISSAIP 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [389-614]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLLRPLYFAV TEPVLVATCF YVCLIYSLLY AFFFAFPVIF GELYGYKDNL VGLMFIPIVI  60
   61 GALWALATTF YCENKYLQIV KQRKPTPEDR LLGAKIGAPF AAIALWILGA TAYKHIIWVG 120
  121 PASAGLAFGF GMVLIYYSLN NYIIDCYVQY ASSALATKVF LRSAGGAAFP LFTIQMYHKL 180
  181 NLHWGSWLLA FISTAMIALP FAFSYWGKGL RHKLSKKDYS IDSVEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.24937104052238 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
binding 1.01584233411372 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [348-388]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETYAPVILKR KAARLRKETG NPKIMTEQEA QGVSMSEMMR A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle