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View Structure Prediction Details

Protein: NNF2
Organism: Saccharomyces cerevisiae
Length: 936 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NNF2.

Description E-value Query
Range		 Subject
Range
NNF2 - Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polyme...
NNF2_YEAST - Protein NNF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NNF2 PE=1 SV=1
 0.0 [1..936] [1..936]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
 3.0E-77 [154..933] [881..1670]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 3.0E-77 [165..934] [896..1668]
MYH2_PIG - Myosin-2 OS=Sus scrofa GN=MYH2 PE=2 SV=1
gi|55741490 - ref|NP_999301.1| myosin heavy chain 2a [Sus scrofa]
 7.0E-77 [173..934] [906..1670]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 1.0E-76 [164..934] [898..1671]

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Predicted Domain #1
Region A:
Residues: [1-208] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEQFTNQKK VSHLQSLMNT KRSEQPTEFA KKHRFKDTLA LFLVFLSFNH FTSLCLLVSF  60
   61 IVATKCKDFL ANCFIILFLS KKPSRHIGEV AHIDISTSKV TNGSSNRKSN SRFFGNSKNS 120
  121 FVIPIPVLIC EILFAMLLKI YGGDYFVKPI KNLAISIIAS FLINDPSDCL SYATSCSVLY 180
  181 AVSTNTFQRV SHFFDIIQLF DMSLRGTG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [209-589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSIKLFTVFR KYSQFFKKLF SLFLPMPFKM LGKHSDSMIY YLSFHILFFS FASSLLHPHR  60
   61 QTAENKPLKK GFNSTKPDVA RVQGLQKMRI SSSSSVSADS NTLEDQSPMI PNDPGGLSSS 120
  121 NQTIHPSQQN NSPVPLSSHS NILNPAASYP TDATSSFPYF TSMVKEYKSY QPSVISAEGS 180
  181 NSQAVTTTTS TTTSPTTFNF SGDNTSLSNE ISLSDSSNGN SKKDSDFFSP SNDKYTNQLF 240
  241 ELNVDFGNMF SSSKLSSDIS VTSNLENFIR LLFRRKNQHL IAPLWSMVVT LKTTNFEKKY 300
  301 LQETSENSLT PTNSNTSYVS NQEKHDKDLD TINTHSVSSR ISFTHAGKFK KSVFNNFEPS 360
  361 NTMALIAKTT SDDYNLLNLV S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [590-657] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNENIFNRND NDYKVCIIDI STNSITFHIE NLHDGELIVL VNGVIWSEVS CALILEHVGE  60
   61 EYVVVNGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.707 d.58.17 Metal-binding domain
View Download 0.639 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.704 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.703 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.617 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.603 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.592 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.589 d.58.17 Metal-binding domain
View Download 0.561 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.550 b.71.1 Glycosyl hydrolase domain
View Download 0.515 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.508 b.71.1 Glycosyl hydrolase domain
View Download 0.503 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.486 d.58.17 Metal-binding domain
View Download 0.482 d.9.2 Description not found.
View Download 0.477 d.58.17 Metal-binding domain
View Download 0.474 d.58.17 Metal-binding domain
View Download 0.469 d.58.24 CheY-binding domain of CheA
View Download 0.466 d.52.1 Alpha-lytic protease prodomain
View Download 0.455 d.58.5 GlnB-like
View Download 0.451 d.58.17 Metal-binding domain
View Download 0.448 d.58.17 Metal-binding domain
View Download 0.439 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.437 d.52.1 Alpha-lytic protease prodomain
View Download 0.432 d.52.1 Alpha-lytic protease prodomain
View Download 0.432 d.58.3 Protease propeptides/inhibitors
View Download 0.414 d.9.2 Description not found.
View Download 0.399 d.9.1 Interleukin 8-like chemokines
View Download 0.386 d.58.5 GlnB-like
View Download 0.386 d.50.1 dsRNA-binding domain-like
View Download 0.385 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.384 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.382 d.9.2 Description not found.
View Download 0.366 d.58.24 CheY-binding domain of CheA
View Download 0.361 b.84.2 Rudiment single hybrid motif
View Download 0.356 d.58.3 Protease propeptides/inhibitors
View Download 0.355 d.9.2 Description not found.
View Download 0.347 d.10.1 DNA-binding domain
View Download 0.343 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.337 d.58.40 D-ribose-5-phosphate isomerase (RpiA), lid domain
View Download 0.336 b.38.1 Sm-like ribonucleoproteins
View Download 0.334 d.58.7 RNA-binding domain, RBD
View Download 0.332 g.7.1 Snake toxin-like
View Download 0.326 g.41.8 Zn-binding ribosomal proteins
View Download 0.323 b.71.1 Glycosyl hydrolase domain
View Download 0.322 d.9.2 Description not found.
View Download 0.319 d.68.3 SirA-like
View Download 0.315 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.310 d.52.1 Alpha-lytic protease prodomain
View Download 0.308 d.52.1 Alpha-lytic protease prodomain
View Download 0.307 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.300 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.295 b.71.1 Glycosyl hydrolase domain
View Download 0.292 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.283 b.36.1 PDZ domain-like
View Download 0.281 d.57.1 DNA damage-inducible protein DinI
View Download 0.280 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.277 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.275 d.129.1 TATA-box binding protein-like
View Download 0.275 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.275 b.71.1 Glycosyl hydrolase domain
View Download 0.274 d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.274 d.68.3 SirA-like
View Download 0.272 d.129.1 TATA-box binding protein-like
View Download 0.269 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.267 c.55.4 Translational machinery components
View Download 0.259 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.258 d.141.1 Ribosomal protein L6
View Download 0.255 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.255 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.250 d.58.17 Metal-binding domain
View Download 0.248 b.101.1 Ribonuclease domain of colicin E3
View Download 0.245 b.34.1 C-terminal domain of transcriptional repressors
View Download 0.242 d.129.1 TATA-box binding protein-like
View Download 0.241 d.68.4 YhbY-like
View Download 0.241 b.71.1 Glycosyl hydrolase domain
View Download 0.241 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.241 d.58.10 Acylphosphatase-like
View Download 0.241 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.239 d.9.2 Description not found.
View Download 0.237 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.234 g.41.3 Zinc beta-ribbon
View Download 0.232 d.129.1 TATA-box binding protein-like
View Download 0.228 d.17.3 Disulfide bond isomerase, DsbC, N-terminal domain
View Download 0.222 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.221 d.68.4 YhbY-like
View Download 0.216 b.84.1 Single hybrid motif
View Download 0.215 d.129.1 TATA-box binding protein-like
View Download 0.212 b.55.1 PH domain-like
View Download 0.211 d.93.1 SH2 domain
View Download 0.210 d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.208 d.93.1 SH2 domain
View Download 0.207 d.68.3 SirA-like
View Download 0.207 b.1.18 E set domains
View Download 0.207 d.68.3 SirA-like
View Download 0.206 d.58.7 RNA-binding domain, RBD
View Download 0.205 c.46.1 Rhodanese/Cell cycle control phosphatase

Predicted Domain #4
Region A:
Residues: [658-711] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPSCSYDIQF INRLNHRDDY LVSDLIVRTC GNNNAIAGKF ENLDFSFPSY YHRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.00940588691795 bayes_pls_golite062009
transcription regulator activity 0.516346942965208 bayes_pls_golite062009
nucleic acid binding 0.513833930010015 bayes_pls_golite062009
DNA binding 0.475884563138359 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [712-789] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLSPLLTLKH SVLTTNANLS DERTKLKKTK KEFSKKLSLL RQEIDYFKGR ISQNATHDEK  60
   61 STLKVENLKV ALQQSETA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [790-852] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNKLEMQLKT LTEKELELEE EYLKKKDLHL KNQLEFSKLE ESLSKDLKNS EGRFQKVNQE  60
   61 LVQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [853-936] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSKLDKLNA RNEKLQKEVD QNAEEIEKFS TQFLSKREKD RFRRKEYRIR EANKFELTIK  60
   61 GLEQDINRLE NENENIHSLI GNSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle