YRC Public Data Repository - Protein Structure Prediction

Protein:	TOM20
Organism:	Saccharomyces cerevisiae
Length:	183 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOM20.

Description	E-value	Query Range	Subject Range
TOM20_YEAST - Mitochondrial import receptor subunit TOM20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... gi\|151943359 - gi\|151943359\|gb\|EDN61672.1\| 20 kDa mitochondrial outer membrane protein import receptor [Saccharomyc... gi\|207345161 - gi\|207345161\|gb\|EDZ72071.1\| YGR082Wp-like protein [Saccharomyces cerevisiae AWRI1631] TOM20 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial... gi\|190406898 - gi\|190406898\|gb\|EDV10165.1\| mitochondrial import receptor subunit TOM20 [Saccharomyces cerevisiae RM...	2.0E-65	[1..183]	[1..183]
gi\|546575 - gi\|546575\|gb\|AAB30680.1\| import receptor MOM19 [Neurospora crassa]	7.0E-47	[10..166]	[8..163]
TOM20_SCHPO - Mitochondrial import receptor subunit tom20 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... tom20 - mitochondrial TOM complex subunit Tom20	3.0E-42	[8..151]	[1..144]
Tom20-PA, FBpp03... - The gene Translocase of outer membrane 20 is referred to in FlyBase by the symbol Dmel\Tom20 (CG7654... gi\|220954130, gi... - gi\|220954130\|gb\|ACL89608.1\| Tom20-PA [synthetic construct], gi\|220944284\|gb\|ACL84685.1\| CG7654-PA [s... gi\|194127821, gi... - gi\|195354334\|ref\|XP_002043653.1\| GM19743 [Drosophila sechellia], gi\|194127821\|gb\|EDW49864.1\| GM19743... gi\|194197585, gi... - gi\|195591699\|ref\|XP_002085576.1\| GD14848 [Drosophila simulans], gi\|194197585\|gb\|EDX11161.1\| GD14848 ...	4.0E-40	[11..171]	[9..149]
CE05705 - mitochondrial precursor receptor status:Confirmed UniProt:Q19766 protein_id:CAA98945.1	1.0E-38	[10..147]	[12..137]
gi\|1838935 - gi\|1838935\|dbj\|BAA09714.1\| mitochondrial precursor receptor [Rattus sp.]	3.0E-38	[9..149]	[4..125]
TOM20_MOUSE - Mitochondrial import receptor subunit TOM20 homolog OS=Mus musculus GN=Tomm20 PE=1 SV=1 TOM20_RAT - Mitochondrial import receptor subunit TOM20 homolog OS=Rattus norvegicus GN=Tomm20 PE=1 SV=2	6.0E-38	[9..149]	[4..125]
gi\|123980398, gi... - gi\|168274282\|dbj\|BAG09561.1\| translocase of outer mitochondrial membrane 20 homolog [synthetic const... TOM20_PONAB - Mitochondrial import receptor subunit TOM20 homolog OS=Pongo abelii GN=TOMM20 PE=2 SV=1 TOMM20 - translocase of outer mitochondrial membrane 20 homolog (yeast) tr\|M3X685\|M3X685... - Translocase of outer mitochondrial membrane 20 OS=Felis catus GN=TOMM20 PE=3 SV=1 tr\|G3GWY3\|G3GWY3... - Mitochondrial import receptor subunit TOM20-like OS=Cricetulus griseus GN=I79_002269 PE=3 SV=1 TOM20_PONPY - Mitochondrial import receptor subunit TOM20 homolog - Pongo pygmaeus (Orangutan) gi\|194042565 - gi\|194042565\|ref\|XP_001926970.1\| PREDICTED: similar to Mitochondrial import receptor subunit TOM20 h... ENSCJAT00000035423 - null tr\|G1TX78\|G1TX78... - pep:novel chromosome:oryCun2:16:33118276:33133165:1 gene:ENSOCUG00000021470 transcript:ENSOCUT000000... gi\|109019950 - gi\|109019950\|ref\|XP_001102478.1\| PREDICTED: translocase of outer mitochondrial membrane 20 homolog (... TOM20_BOVIN - Mitochondrial import receptor subunit TOM20 homolog OS=Bos taurus GN=TOMM20 PE=2 SV=1 gi\|114573267, gi... - gi\|114573269\|ref\|XP_001153572.1\| PREDICTED: translocase of outer mitochondrial membrane 20 homolog i...	1.0E-37	[9..149]	[4..125]
TOM20_RAT, OM20_RAT - Mitochondrial import receptor subunit TOM20 homolog - Rattus norvegicus (Rat), (Q62760) Mitochondria...	2.0E-37	[9..149]	[4..125]

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Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSNPILRG LAITTAIAAL SATGYAIYFD YQRRNSPQFR KVLRQRAKEQ AKMEEQAKTH  60
   61 AKEVKLQKVT EFLS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	8.823909
Match:	PF02064
Description:	MAS20 protein import receptor

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.916	0.007	mitochondrial outer membrane	a.2.8	Eukaryotic DNA topoisomerase I, dispensable insert domain

Predicted Domain #2

Region A:
Residues: [75-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELAKDPIPS DPSEREATFT TNVENGERLS MQQGKELEAA SKFYKALTVY PQPADLLGIY  60
   61 QRSIPEAIYE YIILMIAILP PANVASFVKG VVGSKAESDA VAEANDIDD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.522879
Match:	1om2A_
Description:	Mitochondrial import receptor subunit Tom20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	3.40898729129243	bayes_pls_golite062009
macromolecule transmembrane transporter activity	3.40898729129243	bayes_pls_golite062009
protein transmembrane transporter activity	2.85488085984023	bayes_pls_golite062009
protein transporter activity	2.05250883327513	bayes_pls_golite062009
transporter activity	1.79559401386194	bayes_pls_golite062009
binding	1.66795187393523	bayes_pls_golite062009
transmembrane transporter activity	1.6303525042646	bayes_pls_golite062009
substrate-specific transporter activity	1.49267876312697	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.3436996680931	bayes_pls_golite062009
protein binding	1.10534436186662	bayes_pls_golite062009
primary active transmembrane transporter activity	1.0671316259706	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.06141451496527	bayes_pls_golite062009
active transmembrane transporter activity	1.01882616059722	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: