YRC Public Data Repository - Protein Structure Prediction

Protein:	YGR031W
Organism:	Saccharomyces cerevisiae
Length:	342 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGR031W.

Description	E-value	Query Range	Subject Range
YGR031W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purifi... IMO32_YEAST - Abhydrolase domain-containing protein IMO32 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...	2.0E-59	[1..342]	[1..342]
HYES_RAT - Bifunctional epoxide hydrolase 2 OS=Rattus norvegicus GN=Ephx2 PE=1 SV=1	2.0E-52	[26..338]	[197..542]
HYES_MOUSE - Bifunctional epoxide hydrolase 2 OS=Mus musculus GN=Ephx2 PE=1 SV=2	1.0E-51	[26..338]	[197..542]
gi\|18420047 - gi\|18420047\|ref\|NP_568381.1\| hydrolase, alpha/beta fold family protein [Arabidopsis thaliana]	7.0E-51	[12..340]	[26..359]
gi\|18482507 - gi\|18482507\|gb\|AAL73575.1\| chloride peroxidase [Burkholderia cepacia]	4.0E-50	[56..338]	[3..272]
gi\|25285628 - pir\|\|F98143 non-heme chloroperoxidase (chloride peroxidase) (cpo-p) (chloroperoxidase P) [imported]... gi\|15158401, gi\|... - gi\|15890215\|ref\|NP_355887.1\| non-heme chloroperoxidase [Agrobacterium tumefaciens str. C58], gi\|1515...	6.0E-50	[23..338]	[18..325]
gi\|10197684 - gi\|10197684\|gb\|AAG14968.1\|AF233336_1 soluble epoxide hydrolase [Homo sapiens]	1.0E-49	[26..338]	[197..544]

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Predicted Domain #1

Region A:
Residues: [1-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMILGKAGIL AQYGTIYVRQ NTIRNNLSSC IFKQSLCAFH SLAKVLQQKQ VPLDLSYDII  60
   61 KRDAVKTGDE GKPRPPIIIL HGLFGNKLNN RSIGRNLNKK LGRDVYLLDL RNHGSSPHSS 120
  121 VHNYEVMSED VKHFITKHEL NTNGGPIIIG HSMGGKVAMM LVLKNPQLCS MLVCIENAPV 180
  181 SLRPNAEFVE YIKALMEIVN DKGKTIRTLK QADEHLAERI GGNELVRRFL LTALKKVKMD 240
  241 NSSSVSSYTF EERIPLATLK DAIVKGEIAA WPLDPARERW TRPALFIRAT QSHYVVDEYL 300
  301 PIIGAFFPRF ETRDIDAGHW VNAEKPGECA ESIVDFVERH ED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.39794
Match:	1cqzA_
Description:	Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39629727416851	bayes_pls_golite062009
lipase activity	0.849473630399459	bayes_pls_golite062009
carboxylesterase activity	0.424330502936163	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.264183693934251	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: