YRC Public Data Repository - Protein Structure Prediction

Protein:	ADH4
Organism:	Saccharomyces cerevisiae
Length:	465 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADH4.

Description	E-value	Query Range	Subject Range
gi\|114845300, gi... - gi\|167039286\|ref\|YP_001662271.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Thermoanaeroba...	493.0	[0..23]	[463..405]
gi\|241903602, gi... - gi\|241903602\|ref\|ZP_04788323.1\| iron-containing alcohol dehydrogenase [Thermoanaerobacter brockii su... gi\|76588428, gi\|... - gi\|76796158\|ref\|ZP_00778525.1\| Iron-containing alcohol dehydrogenase [Thermoanaerobacter ethanolicus...	492.0	[0..23]	[463..405]
gi\|111143367 - gi\|111143367\|gb\|ABH06551.1\| alcohol/aldehyde dehydrogenase [Thermoanaerobacter ethanolicus]	490.0	[0..23]	[463..405]
gi\|169298566, gi... - gi\|169343268\|ref\|ZP_02864279.1\| aldehyde-alcohol dehydrogenase [Clostridium perfringens C str. JGS14... gi\|18311513, gi\|... - gi\|18311513\|ref\|NP_563447.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Clostridium perfri... gi\|182380321, gi... - gi\|182380321\|gb\|EDT77800.1\| aldehyde-alcohol dehydrogenase [Clostridium perfringens NCTC 8239], gi\|1... gi\|170715023, gi... - gi\|170715023\|gb\|EDT27205.1\| aldehyde-alcohol dehydrogenase [Clostridium perfringens CPE str. F4969],... gi\|170712167, gi... - gi\|170712167\|gb\|EDT24349.1\| aldehyde-alcohol dehydrogenase [Clostridium perfringens B str. ATCC 3626... gi\|170662702, gi... - gi\|170662702\|gb\|EDT15385.1\| aldehyde-alcohol dehydrogenase [Clostridium perfringens E str. JGS1987],...	488.0	[0..23]	[464..386]
gi\|110673221, gi... - gi\|110798574\|ref\|YP_697219.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Clostridium perfr...	488.0	[0..23]	[464..386]
gi\|110802422, gi... - gi\|110802422\|ref\|YP_699787.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Clostridium perfr...	488.0	[0..23]	[464..386]
gi\|28211045, gi\|... - gi\|28211045\|ref\|NP_781989.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Clostridium tetani...	485.0	[0..22]	[464..385]
gi\|30022446, gi\|... - gi\|30022446\|ref\|NP_834077.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus AT... gi\|228653768, gi... - gi\|229129651\|ref\|ZP_04258619.1\| Alcohol dehydrogenase, iron-containing [Bacillus cereus BDRD-Cer4], ...	485.0	[0..22]	[464..395]
gi\|68053559, gi\|... - gi\|68053559\|ref\|ZP_00537724.1\| Iron-containing alcohol dehydrogenase [Exiguobacterium sibiricum 255-...	484.0	[0..2]	[464..376]
gi\|47505044, gi\|... - gi\|47529896\|ref\|YP_021245.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthracis... gi\|30259099, gi\|... - gi\|30264441\|ref\|NP_846818.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthracis... gi\|190566856, gi... - gi\|190566856\|ref\|ZP_03019772.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis Tsiankovskii-I], ... gi\|170707416, gi... - gi\|170707416\|ref\|ZP_02897870.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0389], gi\|1... gi\|170687429, gi... - gi\|170687429\|ref\|ZP_02878646.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0465], gi\|1... gi\|167638534, gi... - gi\|167638534\|ref\|ZP_02396810.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0193], gi\|1... gi\|229604754, gi... - gi\|229604754\|ref\|YP_002868660.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0248], gi\|... gi\|167529979, gi... - gi\|167634527\|ref\|ZP_02392847.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0442], gi\|1... gi\|227006524, gi... - gi\|227817150\|ref\|YP_002817159.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. CDC 684], g... gi\|165872736, gi... - gi\|165872736\|ref\|ZP_02217364.1\| aldehyde-alcohol dehydrogenase [Bacillus anthracis str. A0488], gi\|1... gi\|254741512 - gi\|254741512\|ref\|ZP_05199199.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthra... gi\|254736474 - gi\|254736474\|ref\|ZP_05194180.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthra... gi\|254721959 - gi\|254721959\|ref\|ZP_05183748.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthra... gi\|254684127 - gi\|254684127\|ref\|ZP_05147987.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthra... gi\|254750950 - gi\|254750950\|ref\|ZP_05202989.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthra... gi\|49187263, gi\|... - gi\|49187263\|ref\|YP_030515.1\| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus anthracis...	484.0	[0..3]	[464..380]

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Predicted Domain #1

Region A:
Residues: [1-74]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGITYAVNS TKQLIFCCLK YLTLLGYILL SNRKKGQRTN MYKRVISISG LLKTGVKRFS  60
   61 SVYCKTTINN KFTF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.844	f.17.1	F1F0 ATP synthase subunit C

Predicted Domain #2

Region A:
Residues: [75-265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATTNSQIRKM SSVTGFYIPP ISFFGEGALE ETADYIKNKD YKKALIVTDP GIAAIGLSGR  60
   61 VQKMLEERDL NVAIYDKTQP NPNIANVTAG LKVLKEQNSE IVVSIGGGSA HDNAKAIALL 120
  121 ATNGGEIGDY EGVNQSKKAA LPLFAINTTA GTASEMTRFT IISNEEKKIK MAIIDNNVTP 180
  181 AVAVNDPSTM F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	432.741366
Match:	1o2dA
Description:	Alcohol dehydrogenase TM0920
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [266-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLPPALTAAT GLDALTHCIE AYVSTASNPI TDACALKGID LINESLVAAY KDGKDKKART  60
   61 DMCYAEYLAG MAFNNASL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	432.741366
Match:	1o2dA
Description:	Alcohol dehydrogenase TM0920
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [344-465]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYVHALAHQL GGFYHLPHGV CNAVLLPHVQ EANMQCPKAK KRLGEIALHF GASQEDPEET  60
   61 IKALHVLNRT MNIPRNLKEL GVKTEDFEIL AEHAMHDACH LTNPVQFTKE QVVAIIKKAY 120
  121 EY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	432.741366
Match:	1o2dA
Description:	Alcohol dehydrogenase TM0920
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits