YRC Public Data Repository - Protein Structure Prediction

Protein:	LSB3
Organism:	Saccharomyces cerevisiae
Length:	451 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LSB3.

Description	E-value	Query Range	Subject Range
gi\|151940785 - gi\|151940785\|gb\|EDN59172.1\| Las17p binding protein [Saccharomyces cerevisiae YJM789] gi\|190406597 - gi\|190406597\|gb\|EDV09864.1\| hypothetical protein SCRG_05571 [Saccharomyces cerevisiae RM11-1a] LSB3 - Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldric...	0.0	[1..451]	[1..451]
YIE2_SCHPO - SH3 domain-containing protein PJ696.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPA... SPAPJ696.02 - actin cortical patch component Lsb4	4.0E-98	[1..450]	[1..429]
SH3YL1 - SH3 domain containing, Ysc84-like 1 (S. cerevisiae) gi\|190689283, gi... - gi\|190690635\|gb\|ACE87092.1\| SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein [synthetic c...	1.0E-80	[3..368]	[1..340]
SH3Y1_MOUSE - SH3 domain-containing YSC84-like protein 1 OS=Mus musculus GN=Sh3yl1 PE=1 SV=1	9.0E-79	[3..368]	[1..338]
gi\|7649363, gi\|2... - gi\|7649363\|emb\|CAB89044.1\| putative protein [Arabidopsis thaliana], gi\|20465341\|gb\|AAM20074.1\| unkno...	2.0E-73	[3..212]	[268..485]

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Predicted Domain #1

Region A:
Residues: [1-362]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGINNPIPRS LKSETNFVKP NQVFGADQVI PPDVLKRAKG LAIITILKAG FLFSGRAGSG  60
   61 VIVARLKDGT WSAPSAIAMA GAGAGGMVGI ELTDFVFILN TQDAVKSFSE FGTITLGGNV 120
  121 SVSAGPLGRS AEAAASASAG GVAAVFAYSK SKGLFAGVSV EGSAIIERRE ANRKFYGDNC 180
  181 TAKMILSGRI RPPPAVDPLF RVLESRAFNY RPSNGGRGSF DDDEDDYYDD DDYYNDIPSS 240
  241 FSSTDASSTR PNTRSTRRRA QSGSRYTFDD DDDDDDYGTG YSRNSRLAPT NSGGSGGKLD 300
  301 DPSGASSYYA SHRRSGTAQS RARSSRNRWA DDEYDDYDDD YESGYRRGNG RDRTKDREVD 360
  361 DL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [363-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNRFSKSRIS SASTPQTSQG RFTAPTSPST SSPKAVALYS FAGEESGDLP FRKGDVITIL  60
   61 KKSDSQNDWW TGRVNGREGI FPANYVELV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.491979
Match:	1semA_
Description:	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	2.99729194621598	bayes_pls_golite062009
protein binding	2.48473240495651	bayes_pls_golite062009
actin binding	2.2471575515877	bayes_pls_golite062009
binding	2.18950934715874	bayes_pls_golite062009
actin filament binding	1.11370928993107	bayes_pls_golite062009
transporter activity	0.164166239570489	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: