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View Structure Prediction Details

Protein: LSB3
Organism: Saccharomyces cerevisiae
Length: 451 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LSB3.

Description E-value Query
Range
Subject
Range
gi|151940785 - gi|151940785|gb|EDN59172.1| Las17p binding protein [Saccharomyces cerevisiae YJM789]
gi|190406597 - gi|190406597|gb|EDV09864.1| hypothetical protein SCRG_05571 [Saccharomyces cerevisiae RM11-1a]
LSB3 - Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldric...
0.0 [1..451] [1..451]
YIE2_SCHPO - SH3 domain-containing protein PJ696.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPA...
SPAPJ696.02 - actin cortical patch component Lsb4
4.0E-98 [1..450] [1..429]
SH3YL1 - SH3 domain containing, Ysc84-like 1 (S. cerevisiae)
gi|190689283, gi... - gi|190690635|gb|ACE87092.1| SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein [synthetic c...
1.0E-80 [3..368] [1..340]
SH3Y1_MOUSE - SH3 domain-containing YSC84-like protein 1 OS=Mus musculus GN=Sh3yl1 PE=1 SV=1
9.0E-79 [3..368] [1..338]
gi|7649363, gi|2... - gi|7649363|emb|CAB89044.1| putative protein [Arabidopsis thaliana], gi|20465341|gb|AAM20074.1| unkno...
2.0E-73 [3..212] [268..485]

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Predicted Domain #1
Region A:
Residues: [1-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGINNPIPRS LKSETNFVKP NQVFGADQVI PPDVLKRAKG LAIITILKAG FLFSGRAGSG  60
   61 VIVARLKDGT WSAPSAIAMA GAGAGGMVGI ELTDFVFILN TQDAVKSFSE FGTITLGGNV 120
  121 SVSAGPLGRS AEAAASASAG GVAAVFAYSK SKGLFAGVSV EGSAIIERRE ANRKFYGDNC 180
  181 TAKMILSGRI RPPPAVDPLF RVLESRAFNY RPSNGGRGSF DDDEDDYYDD DDYYNDIPSS 240
  241 FSSTDASSTR PNTRSTRRRA QSGSRYTFDD DDDDDDYGTG YSRNSRLAPT NSGGSGGKLD 300
  301 DPSGASSYYA SHRRSGTAQS RARSSRNRWA DDEYDDYDDD YESGYRRGNG RDRTKDREVD 360
  361 DL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [363-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNRFSKSRIS SASTPQTSQG RFTAPTSPST SSPKAVALYS FAGEESGDLP FRKGDVITIL  60
   61 KKSDSQNDWW TGRVNGREGI FPANYVELV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 117.491979
Match: 1semA_
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.99729194621598 bayes_pls_golite062009
protein binding 2.48473240495651 bayes_pls_golite062009
actin binding 2.2471575515877 bayes_pls_golite062009
binding 2.18950934715874 bayes_pls_golite062009
actin filament binding 1.11370928993107 bayes_pls_golite062009
transporter activity 0.164166239570489 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle