YRC Public Data Repository - Protein Structure Prediction

Protein:	ALR2
Organism:	Saccharomyces cerevisiae
Length:	858 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALR2.

Description	E-value	Query Range	Subject Range
ALR2 - Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; p... ALR2_YEAST - Magnesium transporter ALR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ALR2 PE=1 SV=...	0.0	[1..858]	[1..858]
YBCC_SCHPO - Putative metal ion transporter C27B12.12c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=... SPBC27B12.12c - CorA family magnesium ion transporter	0.0	[156..796]	[229..800]
gi\|2257556 - gi\|2257556\|dbj\|BAA21448.1\| probable membrane protein YOL130w [Schizosaccharomyces pombe]	0.0	[222..796]	[1..496]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[296..797]	[1..449]
CORA_THEMA - Cobalt/magnesium transport protein CorA OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 ... CORA_THEMA - Magnesium transport protein CorA OS=Thermotoga maritima GN=corA PE=1 SV=1	8.0E-72	[398..799]	[11..348]
gi\|25295831 - pir\|\|AG2319 hypothetical protein all4110 [imported] - Nostoc sp. (strain PCC 7120) gi\|17231602, gi\|... - gi\|17231602\|ref\|NP_488150.1\| hypothetical protein all4110 [Nostoc sp. PCC 7120], gi\|17133245\|dbj\|BAB...	1.0E-70	[397..799]	[24..368]
gi\|7441679 - pir\|\|S75981 magnesium/cobalt transport protein sll0507 - Synechocystis sp. (strain PCC 6803) gi\|1001341, gi\|1... - gi\|16332029\|ref\|NP_442757.1\| magnesium and cobalt transport protein [Synechocystis sp. PCC 6803], gi...	1.0E-67	[397..808]	[36..386]

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Predicted Domain #1

Region A:
Residues: [1-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLSTSFDS SSDLPRSKSV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE ALALKVDETK  60
   61 DSRHKFSSSN GENSGVENGG YVEKTNISTS GRMDFEGEAE AEAVKRYQLR SFALLSSNAR 120
  121 PSRLAKSETH QKQIHVESIA PSLPKNAALE RGHDTALPAG TSSNRCNLEA SSSARTFTSA 180
  181 RKASLVSAIF ETSAESEHGT HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND 240
  241 TRRIKPLRMD SRVSFHSEIS QASRDSQETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS 300
  301 NAERNLSLAN HQRHSERTYN HTDQDTGFTN SASTSGSSAA LKYTPEISRT LEKNCSVNEM 360
  361 YVSENNESVR ED

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [373-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKPDLHPDVT FGRNKIEGEK EGNDSSYSRA YYTLQNTEYQ IPSRFSFFRS ESDETVHASD  60
   61 IPSLISEGQT FYELFKGGDP TWWLDCSCPT DDEMRCIAKT FGIHPLTAED IRMQETREKV 120
  121 ELFKSYYFVC FHTFENDKES ENYLEPINVY IVVFRSGVLT FHFDPISHCA NVRRRVRQLR 180
  181 DY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [555-701]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSVNSDWLCY ALIDDITDSF APVIQSIEYE ADSIDDSVFM TRDMDFAAML QRIGESRRKT  60
   61 MTLMRLLSGK ADVIKMFAKR CQDETNGIGP VLKSQTNMVN LQAEQENVNQ NNSNNQISLS 120
  121 NSYMQTTSQP RGDIALYLGD IQDHLLT

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.94
Match:	1hciA
Description:	alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [702-858]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQNLLAYEK IFSRSHANYL AQLQVESFNS NNKVTEMLGK VTMLGTMLVP LNVITGLFGM  60
   61 NVKVPGRNGS IAWWYGILGV LLLLAVISWF LASYWIKKID PPATLNEAAG SGAKSVISSF 120
  121 LPKRDKRFND DSKNGNARVG VRRKSTVSLP SRYSRYN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits