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View Structure Prediction Details

Protein: EMP47
Organism: Saccharomyces cerevisiae
Length: 445 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMP47.

Description E-value Query
Range		 Subject
Range
EMP47 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function i...
EMP47_YEAST - Protein EMP47 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EMP47 PE=1 SV=1
 0.0 [1..445] [1..445]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [12..383] [20..416]
LMAN1 - lectin, mannose-binding, 1
 0.0 [12..383] [20..416]
LMAN1_CHLAE - Protein ERGIC-53 OS=Chlorocebus aethiops GN=LMAN1 PE=2 SV=1
 0.0 [12..383] [20..416]
LMAN1_MOUSE - Protein ERGIC-53 OS=Mus musculus GN=Lman1 PE=1 SV=1
 0.0 [12..383] [20..424]
LMAN1_RAT - Protein ERGIC-53 OS=Rattus norvegicus GN=Lman1 PE=1 SV=1
 0.0 [12..383] [20..424]
ergic53-PA, ergi... - The gene ergic53 is referred to in FlyBase by the symbol Dmel\ergic53 (CG6822, FBgn0035909). It is a...
gi|220956014 - gi|220956014|gb|ACL90550.1| ergic53-PA [synthetic construct]
 0.0 [28..356] [25..369]

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Predicted Domain #1
Region A:
Residues: [1-265] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMLITMKST VLLSVFTVLA TWAGLLEAHP LGDTSDASKL SSDYSLPDLI NARKVPNNWQ  60
   61 TGEQASLEEG RIVLTSKQNS KGSLWLKQGF DLKDSFTMEW TFRSVGYSGQ TDGGISFWFV 120
  121 QDSNVPRDKQ LYNGPVNYDG LQLLVDNNGP LGPTLRGQLN DGQKPVDKTK IYDQSFASCL 180
  181 MGYQDSSVPS TIRVTYDLED DNLLKVQVDN KVCFQTRKVR FPSGSYRIGV TAQNGAVNNN 240
  241 AESFEIFKMQ FFNGVIEDSL IPNVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.0
Match: 1gv9A_
Description: Carbohydrate-recognition domain of P58/ERGIC-53
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.52142098960755 bayes_pls_golite062009
transporter activity 1.29150662073327 bayes_pls_golite062009
protein binding 1.15590148654655 bayes_pls_golite062009
transmembrane transporter activity 1.07075219961504 bayes_pls_golite062009
carbohydrate binding 0.706875336696662 bayes_pls_golite062009
substrate-specific transporter activity 0.546512480767482 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.301823428566403 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [266-445] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMGQPKLITK YIDQQTGKEK LIEKTAFDAD KDKITNYELY KKLDRVEGKI LANDINALET  60
   61 KLNDVIKVQQ ELLSFMTTIT KQLSSKPPAN NEKGTSTDDA IAEDKENFKD FLSINQKLEK 120
  121 VLVEQEKYRE ATKRHGQDGP QVDEIARKLM IWLLPLIFIM LVMAYYTFRI RQEIIKTKLL 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.819 N/A N/A a.47.2 t-snare proteins

YRC Informatics Platform - Version 3.0
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