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View Structure Prediction Details

Protein: EPL1
Organism: Saccharomyces cerevisiae
Length: 832 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EPL1.

Description E-value Query
Range
Subject
Range
EPL1_ASHGO - Enhancer of polycomb-like protein 1 OS=Ashbya gossypii GN=EPL1 PE=3 SV=1
EPL1_ASHGO - Enhancer of polycomb-like protein 1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 /...
492.0 [0..24] [770..3]
EPL1_CANGA - Enhancer of polycomb-like protein 1 OS=Candida glabrata GN=EPL1 PE=3 SV=1
EPL1_CANGA - Enhancer of polycomb-like protein 1 OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBR...
478.0 [0..30] [831..31]
gi|114629987 - gi|114629987|ref|XP_001141530.1| PREDICTED: enhancer of polycomb 1 isoform 3 [Pan troglodytes]
414.0 [0..51] [494..2]
gi|22328090 - gi|22328090|gb|AAH36529.1| EPC1 protein [Homo sapiens]
410.0 [0..51] [494..2]
gi|73948769, gi|... - gi|73948769|ref|XP_859232.1| PREDICTED: similar to enhancer of polycomb 1 isoform 5 [Canis familiari...
409.0 [0..51] [494..2]
gi|109505898, gi... - gi|62663676|ref|XP_225457.3| PREDICTED: similar to enhancer of polycomb homolog 1 isoform 2 [Rattus ...
393.0 [0..51] [494..2]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTPSNAIEI NDGSHKSGRS TRRSGSRSAH DDGLDSFSKG DSGAGASAGS SNSRFRHRKI  60
   61 SVKQHLKIYL PNDLKHLDKD ELQQREVVEI ET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [93-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVEKNEEKEV HLHRILQMGS GHTKHKDYIP TPDASMTWNE YDKFYTGSFQ ETTSYIKFSA  60
   61 TVEDC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [158-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CGTNYNMDER DETFLNEQVN KGSSDILTED EFEILCSSFE HAIHERQPFL SMDPESILSF  60
   61 EELKPTLIKS DM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [230-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADFNLRNQLN HEINSHKTHF ITQFDPVSQM NTRPLIQLIE KFGSKIYDYW RERKIEVNGY  60
   61 EIFPQLKFER PGEKEEIDPY VCFRRREVRH PRKTRRIDIL NSQRLRALHQ ELKNAKDLAL 120
  121 LVAKRENVSL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.154902
Match: 1eqfA
Description: TAFII250 double bromodomain module
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [360-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NWINDELKIF DQRVKIKNLK RSLNISGEDD DLINHKRKRP TIVTVEQREA ELRKAELKRA  60
   61 AAAAAAAKAK NNKRNNQLED KSSRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.154902
Match: 1eqfA
Description: TAFII250 double bromodomain module
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [445-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKQQQQQLLQ QQQQQQQNAL KTENGKQLAN ASSSSTSQPI TSHVYVKLPS SKIPDIVLED  60
   61 VDALLNSKEK NARKFVQEKM EKRKIEDADV FFNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [539-832]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDDPFNPVFD MSLPKNFSTS NVPFASIASS KFQIDRSFYS SHLPEYLKGI SDDIRIYDSN  60
   61 GRSRNKDNYN LDTKRIKKTE LYDPFQENLE IHSREYPIKF RKRVGRSNIK YVDRMPNFTT 120
  121 SSTKSACSLM DFVDFDSIEK EQYSREGSND TDSINVYDSK YDEFVRLYDK WKYDSPQNEY 180
  181 GIKFSDEPAR LNQISNDTQV IRFGTMLGTK SYEQLREATI KYRRDYITRL KQKHIQHLQQ 240
  241 QQQQQQQQQQ QAQQQKQKSQ NNNSNSSNSL KKLNDSLINS EAKQNSSITQ KNSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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