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View Structure Prediction Details

Protein: PAB1
Organism: Saccharomyces cerevisiae
Length: 577 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAB1.

Description E-value Query
Range
Subject
Range
gi|172092 - gi|172092|gb|AAA34838.1| polyadenylate-binding protein
0.0 [1..577] [1..577]
gi|126540996, gi... - gi|22507391|ref|NP_683717.1| poly(A) binding protein, cytoplasmic 4 isoform 2 [Mus musculus], gi|163...
0.0 [29..573] [2..604]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
0.0 [32..572] [5..607]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
0.0 [29..573] [2..624]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
0.0 [29..573] [2..624]
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
0.0 [29..566] [2..616]
gi|7528270 - gi|7528270|gb|AAF63202.1|AF240679_1 poly(A)-binding protein [Cucumis sativus]
0.0 [16..576] [7..637]

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Predicted Domain #1
Region A:
Residues: [1-116]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADITDKTAE QLENLNIQDD QKQAATGSES QSVENSSASL YVGDLEPSVS EAHLYDIFSP  60
   61 IGSVSSIRVC RDAITKTSLG YAYVNFNDHE AGRKAIEQLN YTPIKGRLCR IMWSQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 653.927757
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.92126426323641 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [117-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPSLRKKGSG NIFIKNLHPD IDNKALYDTF SVFGDILSSK IATDENGKSK GFGFVHFEEE  60
   61 GAAKEAIDAL NGMLLNGQEI YVAPHLSRKE RDSQLEETK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 653.927757
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [216-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHYTNLYVKN INSETTDEQF QELFAKFGPI VSASLEKDAD GKLKGFGFVN YEKHEDAVKA  60
   61 VEALNDSELN GEKLYVGRAQ KKNERMHVLK KQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.31133
Match: 1l3kA_
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [308-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEAYRLEKMA KYQGVNLFVK NLDDSVDDEK LEEEFAPYGT ITSAKVMRTE NGKSKGFGFV  60
   61 CFSTPEEATK AITEKNQQIV AGKPLYVAIA QRKDVRRSQL AQQIQARNQM RYQQATAAAA 120
  121 AAAAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 128.31133
Match: 1l3kA_
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [433-485]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGQFMPPMF YGVMPPRGVP FNGPNPQQMN PMGGMPKNGM PPQFRNGPVY GVP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.530 a.4.1 Homeodomain-like
View Download 0.374 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.497 a.4.1 Homeodomain-like
View Download 0.381 a.4.1 Homeodomain-like
View Download 0.325 a.4.5 "Winged helix" DNA-binding domain
View Download 0.269 a.60.2 RuvA domain 2-like
View Download 0.238 a.159.2 FF domain

Predicted Domain #6
Region A:
Residues: [486-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQGGFPRNAN DNNQFYQQKQ RQALGEQLYK KVSAKTSNEE AAGKITGMIL DLPPQEVFPL  60
   61 LESDELFEQH YKEASAAYES FKKEQEQQTE QA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 390.67837
Match: 1ifwA_
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle