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View Structure Prediction Details

Protein: YER140W
Organism: Saccharomyces cerevisiae
Length: 556 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YER140W.

Description E-value Query
Range
Subject
Range
YER140W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purifi...
gi|190405699 - gi|190405699|gb|EDV08966.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
TAPT1_YEAST - Endoplasmic reticulum membrane protein 65 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
0.0 [1..556] [1..556]
gi|17381092 - gi|17381092|gb|AAL36358.1| unknown protein [Arabidopsis thaliana]
0.0 [28..460] [190..614]
CE19819 - status:Confirmed UniProt:Q9U3H8 protein_id:CAB62802.1
0.0 [37..461] [144..530]
TAPT1_SCHPO - Endoplasmic reticulum membrane protein 65 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...
SPBC13G1.05 - DUF747 family protein
0.0 [7..410] [63..496]
gi|125545511 - gi|125545511|gb|EAY91650.1| hypothetical protein OsI_012883 [Oryza sativa (indica cultivar-group)]
gi|125587706, gi... - gi|50918313|ref|XP_469553.1| hypothetical protein [Oryza sativa (japonica cultivar-group)], gi|18071...
2.0E-74 [193..449] [257..494]
gi|23957778, gi|... - gi|8052286|emb|CAB39065.2| hypothetical protein [Plasmodium falciparum 3D7], gi|23957778|ref|NP_4733...
1.0E-41 [227..378] [1038..1184]
gi|6760350 - gi|6760350|gb|AAF28308.1| cytomegalovirus partial fusion receptor [Homo sapiens]
2.0E-15 [140..193] [65..118]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQHKDTAVAK DTAKKRLLRR NSAPSAIHII SRLDKKWSFL WNTIDRHNIV EEQDESSAAK  60
   61 SEEEHEDDYE LEQLLNMIRI PMFLEKFMLF ALLTSLDCFL YYFTVLPIRL IKGYVKQFKS 120
  121 YRQHYRLQQR SGHKNKIPF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.224 0.839 mitochondrion c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.202 0.839 mitochondrion a.1.1 Globin-like
View Download 0.237 0.839 mitochondrion f.14.1 Voltage-gated potassium channels
View Download 0.202 0.839 mitochondrion b.34.8 Fumarylacetoacetate hydrolase, FAH, N-terminal domain
View Download 0.385 0.839 mitochondrion c.20.1 Initiation factor IF2/eIF5b, domain 3
View Download 0.385 0.839 mitochondrion c.20.1 Initiation factor IF2/eIF5b, domain 3
View Download 0.237 0.839 mitochondrion f.14.1 Voltage-gated potassium channels
View Download 0.224 0.839 mitochondrion c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.202 0.839 mitochondrion a.1.1 Globin-like
View Download 0.202 0.839 mitochondrion b.34.8 Fumarylacetoacetate hydrolase, FAH, N-terminal domain

Predicted Domain #2
Region A:
Residues: [140-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RYRITSREYK ERCMIFIIVI SSILLSKLDT SKLYHRIKRQ STMKLYMLFS VLEMADKMLA  60
   61 SLGQSLLTVM LSRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.811 0.003 mitochondrion a.2.3 Chaperone J-domain
View Download 0.627 0.002 mitochondrion a.16.1 S15/NS1 RNA-binding domain
View Download 0.616 0.001 mitochondrion a.2.7 tRNA-binding arm
View Download 0.816 0.000 mitochondrion f.17.1 F1F0 ATP synthase subunit C
View Download 0.743 0.000 mitochondrion a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.816 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.811 N/A N/A a.2.3 Chaperone J-domain
View Download 0.743 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.719 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.710 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.612 N/A N/A a.4.1 Homeodomain-like
View Download 0.559 N/A N/A a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.490 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.486 N/A N/A a.77.1 DEATH domain
View Download 0.468 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.435 N/A N/A a.2.2 Ribosomal protein L29 (L29p)
View Download 0.425 N/A N/A a.30.1 ROP protein
View Download 0.417 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.402 N/A N/A a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.396 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.387 N/A N/A d.216.1 Rotavirus NSP2 fragment, N-terminal domain
View Download 0.385 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.373 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.371 N/A N/A a.16.1 S15/NS1 RNA-binding domain
View Download 0.364 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.354 N/A N/A d.56.1 GroEL-intermediate domain like
View Download 0.352 N/A N/A f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.351 N/A N/A a.59.1 PAH2 domain
View Download 0.338 N/A N/A a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.336 N/A N/A a.138.1 Multiheme cytochromes
View Download 0.329 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.326 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.324 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.319 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.318 N/A N/A d.57.1 DNA damage-inducible protein DinI
View Download 0.316 N/A N/A a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.316 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.311 N/A N/A d.58.13 Anticodon-binding domain of PheRS
View Download 0.306 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.304 N/A N/A f.15.1 Small-conductance potassium channel
View Download 0.299 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.294 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.291 N/A N/A a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.290 N/A N/A a.112.1 Description not found.
View Download 0.290 N/A N/A a.157.1 Skp1 dimerisation domain-like
View Download 0.285 N/A N/A a.4.12 TrpR-like
View Download 0.285 N/A N/A a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.284 N/A N/A a.23.5 Hemolysin expression modulating protein HHA
View Download 0.281 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.280 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.274 N/A N/A a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.271 N/A N/A a.2.7 tRNA-binding arm
View Download 0.271 N/A N/A a.156.1 S13-like H2TH domain
View Download 0.270 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.269 N/A N/A a.64.1 Saposin
View Download 0.264 N/A N/A a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.259 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.254 N/A N/A a.64.1 Saposin
View Download 0.253 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.252 N/A N/A a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.250 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.247 N/A N/A f.13.1 Family A G protein-coupled receptor-like
View Download 0.247 N/A N/A a.144.1 PABC (PABP) domain
View Download 0.240 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.236 N/A N/A f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.232 N/A N/A a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.231 N/A N/A a.22.1 Histone-fold
View Download 0.221 N/A N/A a.4.1 Homeodomain-like
View Download 0.221 N/A N/A a.51.1 Cytochrome c oxidase subunit h
View Download 0.220 N/A N/A d.78.1 RPB5-like RNA polymerase subunit
View Download 0.220 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.219 N/A N/A a.4.1 Homeodomain-like
View Download 0.215 N/A N/A a.46.1 Methionine synthase domain
View Download 0.215 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.214 N/A N/A d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.212 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.205 N/A N/A d.95.2 Homing endonucleases

Predicted Domain #3
Region A:
Residues: [214-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSERILLHKC LLVSMSLTYV TIHGYVLVYQ AISLNIAVNS YSNALLTLLL SMQFAEIKSS  60
   61 VLKKFDKEGF FQITIADVVE RFKLTLLLSI TGLRNLQSWS SSLSNTSINF WSPRSTLSIV 120
  121 INILCGPMVS VVGSEVLVDW AKHAYITKFN RIRPQIYDKF YYIIYKDYST RTHKLEDRLG 180
  181 LPLPAFVVLF IVMVRPTLFK SS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [416-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPSYLPSLFR ILFMGASVFL LALLAKFTLD LILIKWSKRI EQRFRDQAFN TVVTEEEYVP  60
   61 GLLSGGMGKV DVSTRIALHS DYNKENRIET ESVSPMRKRK TTLTAECTPP SLNDIRRQKD 120
  121 SKNPRSLENV ARYKMVSKRI W

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.231 d.19.1 MHC antigen-recognition domain
View Download 0.279 a.47.2 t-snare proteins
View Download 0.314 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.314 a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.279 a.47.2 t-snare proteins
View Download 0.231 d.19.1 MHC antigen-recognition domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle