YRC Public Data Repository - Protein Structure Prediction

Protein:	THO1
Organism:	Saccharomyces cerevisiae
Length:	218 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THO1.

Description	E-value	Query Range	Subject Range
gi\|49641697, gi\|... - gi\|50305211\|ref\|XP_452564.1\| unnamed protein product [Kluyveromyces lactis], gi\|49641697\|emb\|CAH0141... gi\|49641697 - gi\|49641697\|emb\|CAH01415.1\| KLLA0C08195p [Kluyveromyces lactis]	114.0	[0..4]	[177..48]
gi\|49527145 - gi\|49527145\|emb\|CAG60783.1\| unnamed protein product [Candida glabrata] gi\|49527145, gi\|... - gi\|50290803\|ref\|XP_447834.1\| unnamed protein product [Candida glabrata], gi\|49527145\|emb\|CAG60783.1\|...	110.0	[0..1]	[213..1]
gi\|49653046 - gi\|49653046\|emb\|CAG85385.1\| DEHA2B09856p [Debaryomyces hansenii] gi\|49653046, gi\|... - gi\|50414217\|ref\|XP_457381.1\| hypothetical protein DEHA0B10098g [Debaryomyces hansenii CBS767], gi\|49...	103.0	[0..1]	[212..1]
gi\|44982565 - gi\|44982565\|gb\|AAS51851.1\| ADL069Wp [Ashbya gossypii ATCC 10895] gi\|44982565, gi\|... - gi\|45187804\|ref\|NP_984027.1\| ADL069Wp [Ashbya gossypii ATCC 10895], gi\|44982565\|gb\|AAS51851.1\| ADL06...	99.0	[0..1]	[177..33]
gi\|23200121 - gi\|23200121\|pdb\|1H1J\|S Chain S, The Sap Domain Is A Dna-Binding Domain Capable Of Binding SMAR DNA	92.0	[0..2]	[50..3]
orf19.7830, orf1... - orf19.200 CGDID:CAL0003866 Assembly 19, Contig19-10045 (6055, 5474) CDS, reverse complemented, trans... gi\|68487106, gi\|... - gi\|68487106\|ref\|XP_712556.1\| hypothetical protein CaO19.7830 [Candida albicans SC5314], gi\|68487049\|...	81.0	[0..1]	[218..1]
gi\|32415918, gi\|... - gi\|32415918\|ref\|XP_328437.1\| predicted protein [Neurospora crassa], gi\|28923570\|gb\|EAA32745.1\| predi... gi\|85105513 - gi\|85105513\|ref\|XP_961981.1\| hypothetical protein NCU07731 [Neurospora crassa OR74A]	61.0	[0..3]	[131..4]
gi\|50555554, gi\|... - gi\|50555554\|ref\|XP_505185.1\| YALI0F08965p [Yarrowia lipolytica], gi\|49651055\|emb\|CAG77992.1\| unnamed... gi\|49651055 - gi\|49651055\|emb\|CAG77992.1\| YALI0F08965p [Yarrowia lipolytica]	56.0	[0..1]	[217..1]
gi\|116195830, gi... - gi\|88180426\|gb\|EAQ87894.1\| hypothetical protein CHGG_04513 [Chaetomium globosum CBS 148.51], gi\|1161...	51.0	[0..3]	[140..4]
gi\|39952533, gi\|... - gi\|39952533\|ref\|XP_363916.1\| hypothetical protein MGG_01842 [Magnaporthe grisea 70-15], gb\|EAA56191....	50.0	[0..3]	[114..4]

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Predicted Domain #1

Region A:
Residues: [1-55]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADYSSLTVV QLKDLLTKRN LSVGGLKNEL VQRLIKDDEE SKGESEVSPQ EQNQE

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	12.0
Match:	PF02037
Description:	SAP domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.493	N/A	N/A	a.140.1	LEM domain
View	Download	0.489	N/A	N/A	a.60.1	SAM/Pointed domain
View	Download	0.444	N/A	N/A	a.140.1	LEM domain
View	Download	0.436	N/A	N/A	a.144.1	PABC (PABP) domain
View	Download	0.436	N/A	N/A	a.144.1	PABC (PABP) domain
View	Download	0.381	N/A	N/A	a.6.1	Putative DNA-binding domain
View	Download	0.381	N/A	N/A	a.6.1	Putative DNA-binding domain
View	Download	0.376	N/A	N/A	a.140.1	LEM domain
View	Download	0.354	N/A	N/A	a.140.1	LEM domain
View	Download	0.340	N/A	N/A	a.140.1	LEM domain

Predicted Domain #2

Region A:
Residues: [56-218]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGSEPAAIEE PASQNITEKK EVSSEPKETN EPKEENKDVQ KPSDGPSATA SENEQAAAST  60
   61 AAPALSPEEI KAKALDLLNK KLHRANKFGQ DQADIDSLQR QINRVEKFGV DLNSKLAEEL 120
  121 GLVSRKNEPE SGNNGKFKNR NKNANNRSRV SKNRRGNRSG YRR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.792	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.792	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.777	a.118.19	Description not found.
View	Download	0.642	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.642	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.575	a.23.3	Methane monooxygenase hydrolase, gamma subunit
View	Download	0.575	a.23.3	Methane monooxygenase hydrolase, gamma subunit
View	Download	0.571	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.571	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.526	a.23.3	Methane monooxygenase hydrolase, gamma subunit

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits