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View Structure Prediction Details

Protein: CIN8
Organism: Saccharomyces cerevisiae
Length: 1038 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CIN8.

Description E-value Query
Range
Subject
Range
gi|3542, gi|171225 - gi|3542|emb|CAA77885.1| Cin8p [Saccharomyces cerevisiae], gi|171225|gb|AAA34496.1| kinesin-related p...
0.0 [1..1038] [1..1038]
gi|4512330 - gi|4512330|dbj|BAA75243.1| KIF1B-beta [Mus musculus]
0.0 [153..959] [5..829]
KIF1B - kinesin family member 1B
0.0 [153..956] [5..872]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [153..1032] [5..869]
gi|8248421 - gi|8248421|gb|AAF74192.1|AF247761_1 kinesin superfamily member DUnc104 [Drosophila melanogaster]
0.0 [176..945] [28..826]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVWPESNVEY RYRSKQFKGK SNKKYIKAQK IQQERICLMP AENQNTGQDR SSNSISKNGN  60
   61 SQVG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.765 0.048 mitotic spindle organization in nucleus d.9.1 Interleukin 8-like chemokines
View Download 0.746 0.048 mitotic spindle organization in nucleus d.58.3 Protease propeptides/inhibitors
View Download 0.955 0.048 mitotic spindle organization in nucleus b.84.2 Rudiment single hybrid motif
View Download 0.718 0.048 mitotic spindle organization in nucleus b.40.6 MOP-like
View Download 0.683 0.048 mitotic spindle organization in nucleus d.9.2 Description not found.
View Download 0.618 0.048 mitotic spindle organization in nucleus d.58.7 RNA-binding domain, RBD
View Download 0.561 0.048 mitotic spindle organization in nucleus d.58.40 D-ribose-5-phosphate isomerase (RpiA), lid domain
View Download 0.433 0.048 mitotic spindle organization in nucleus d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.401 0.048 mitotic spindle organization in nucleus d.58.17 Metal-binding domain
View Download 0.394 0.048 mitotic spindle organization in nucleus b.5.1 alpha-Amylase inhibitor tendamistat
View Download 0.389 0.048 mitotic spindle organization in nucleus a.6.1 Putative DNA-binding domain
View Download 0.362 0.048 mitotic spindle organization in nucleus d.129.1 TATA-box binding protein-like
View Download 0.354 0.048 mitotic spindle organization in nucleus b.1.18 E set domains
View Download 0.353 0.048 mitotic spindle organization in nucleus b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.338 0.048 mitotic spindle organization in nucleus d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.323 0.048 mitotic spindle organization in nucleus d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.316 0.048 mitotic spindle organization in nucleus d.50.1 dsRNA-binding domain-like
View Download 0.291 0.048 mitotic spindle organization in nucleus g.3.11 EGF/Laminin
View Download 0.291 0.048 mitotic spindle organization in nucleus d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.277 0.048 mitotic spindle organization in nucleus d.52.4 YhbC-like, N-terminal domain
View Download 0.272 0.048 mitotic spindle organization in nucleus d.58.11 EF-G/eEF-2 domains III and V
View Download 0.267 0.048 mitotic spindle organization in nucleus b.40.4 Nucleic acid-binding proteins
View Download 0.265 0.048 mitotic spindle organization in nucleus b.40.2 Bacterial enterotoxins
View Download 0.254 0.048 mitotic spindle organization in nucleus d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.253 0.048 mitotic spindle organization in nucleus g.52.1 Inhibitor of apoptosis (IAP) repeat
View Download 0.250 0.048 mitotic spindle organization in nucleus b.71.1 Glycosyl hydrolase domain
View Download 0.231 0.048 mitotic spindle organization in nucleus g.52.1 Inhibitor of apoptosis (IAP) repeat
View Download 0.223 0.048 mitotic spindle organization in nucleus d.222.1 YbaB-like
View Download 0.218 0.048 mitotic spindle organization in nucleus d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.216 0.048 mitotic spindle organization in nucleus c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.212 0.048 mitotic spindle organization in nucleus d.58.5 GlnB-like
View Download 0.212 0.048 mitotic spindle organization in nucleus d.93.1 SH2 domain
View Download 0.203 0.048 mitotic spindle organization in nucleus d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.201 0.048 mitotic spindle organization in nucleus g.24.1 TNF receptor-like
View Download 0.200 0.048 mitotic spindle organization in nucleus d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains

Predicted Domain #2
Region A:
Residues: [65-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CHTVPNEELN ITVAVRCRGR NEREISMKSS VVVNVPDITG SKEISINTTG DTGITAQMNA  60
   61 KRYTVDKVFG PGASQDLIFD EVAGPLFQDF IKGYNCTVLV YGMTSTGKTY TMTGDEKLYN 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.639 0.057 mitotic spindle organization in nucleus d.80.1 Tautomerase/MIF
View Download 0.693 0.039 mitotic spindle organization in nucleus c.16.1 Lumazine synthase
View Download 0.581 0.033 mitotic spindle organization in nucleus c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.678 0.011 mitotic spindle organization in nucleus c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.624 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.561 N/A N/A c.48.1 TK C-terminal domain-like
View Download 0.555 N/A N/A c.95.1 Thiolase-like
View Download 0.554 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.552 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.545 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.514 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.507 N/A N/A c.23.1 CheY-like
View Download 0.469 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.455 N/A N/A c.23.1 CheY-like
View Download 0.454 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.446 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.438 N/A N/A c.23.5 Flavoproteins
View Download 0.437 N/A N/A b.1.1 Immunoglobulin
View Download 0.436 N/A N/A d.20.1 UBC-like
View Download 0.410 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.409 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.405 N/A N/A d.73.1 RuBisCO, small subunit
View Download 0.391 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.377 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.377 N/A N/A d.129.4 Cell-division protein ZipA, C-terminal domain
View Download 0.371 N/A N/A c.16.1 Lumazine synthase
View Download 0.362 N/A N/A d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.360 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.355 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.355 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.342 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.340 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.336 N/A N/A d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.334 N/A N/A d.58.47 Hypothetical protein VC0424
View Download 0.331 N/A N/A d.52.6 BolA-like
View Download 0.329 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.328 N/A N/A d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.326 N/A N/A a.39.1 EF-hand
View Download 0.326 N/A N/A b.29.1 Concanavalin A-like lectins/glucanases
View Download 0.318 N/A N/A d.93.1 SH2 domain
View Download 0.315 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.311 N/A N/A d.79.1 YjgF-like
View Download 0.310 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.303 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.300 N/A N/A c.55.1 Actin-like ATPase domain
View Download 0.295 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.292 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.288 N/A N/A b.1.18 E set domains
View Download 0.281 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.275 N/A N/A d.58.13 Anticodon-binding domain of PheRS
View Download 0.274 N/A N/A d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.273 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.273 N/A N/A b.8.1 TRAF domain-like
View Download 0.265 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.263 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.261 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.260 N/A N/A d.227.1 OsmC-like
View Download 0.259 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.252 N/A N/A c.61.1 PRTase-like
View Download 0.246 N/A N/A c.23.4 Succinyl-CoA synthetase domains
View Download 0.246 N/A N/A c.23.5 Flavoproteins
View Download 0.243 N/A N/A b.40.2 Bacterial enterotoxins
View Download 0.233 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.233 N/A N/A c.43.1 CoA-dependent acyltransferases
View Download 0.232 N/A N/A c.23.5 Flavoproteins
View Download 0.228 N/A N/A c.23.1 CheY-like
View Download 0.227 N/A N/A d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.226 N/A N/A c.97.1 Cytidine deaminase-like
View Download 0.226 N/A N/A c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.226 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.226 N/A N/A c.52.3 Eukaryotic RPB5 N-terminal domain
View Download 0.221 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.220 N/A N/A d.208.1 MTH1598-like
View Download 0.216 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.215 N/A N/A d.93.1 SH2 domain
View Download 0.207 N/A N/A c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.206 N/A N/A b.45.1 FMN-binding split barrel
View Download 0.205 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains

Predicted Domain #3
Region A:
Residues: [185-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELSDAAGII PRVLLKLFDT LELQQNDYVV KCSFIELYNE ELKDLLDSNS NGSSNTGFDG  60
   61 QFMKKLRIFD SSTANNTTSN SASSSRSNSR NSSPRSLNDL TPKAALLRKR LRTKSLPNTI 120
  121 KQQYQQQQAV NSRNNSSSNS GSTTNNASSN TNTNNGQRSS MAPNDQTNGI YIQNLQEFHI 180
  181 TNAMEGLNLL QKGLKHRQVA STKMNDFSSR SHTIFTITLY KKHQDELFRI SKMNLVDLAG 240
  241 SENINRSGAL NQRAKEAGSI NQSLLTLGRV INALVDKSGH IPFRESKLTR LLQDSLGGNT 300
  301 KTALIATISP AKVTSEETCS TLEYASKAKN IKNKPQLGSF IMKDILVKNI TMELAKIKSD 360
  361 LLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 586.491979
Match: 1ii6A_
Description: Kinesin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [548-735]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKSKEGIYMS QDHYKNLNSD LESYKNEVQE CKREIESLTS KNALLVKDKL KSKETIQSQN  60
   61 CQIESLKTTI DHLRAQLDKQ HKTEIEISDF NNKLQKLTEV MQMALHDYKK RELDLNQKFE 120
  121 MHITKEIKKL KSTLFLQLNT MQQESILQET NIQPNLDMIK NEVLTLMRTM QEKAELMYKD 180
  181 CVKKILNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [736-1038]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKFFNVVIE KIDIIRVDFQ KFYKNIAENL SDISEENNNM KQYLKNHFFK NNHQELLNRH  60
   61 VDSTYENIEK RTNEFVENFK KVLNDHLDEN KKLIMQNLTT ATSAVIDQEM DLFEPKRVKW 120
  121 ENSFDLINDC DSMNNEFYNS MAATLSQIKS TVDTSSNSMN ESISVMKGQV EESENAISLL 180
  181 KNNTKFNDQF EQLINKHNML KDNIKNSITS THSHITNVDD IYNTIENIMK NYGNKENATK 240
  241 DEMIENILKE IPNLSKKMPL RLSNINSNSV QSVISPKKHA IEDENKSSEN VDNEGSRKML 300
  301 KIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle