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View Structure Prediction Details

Protein: VAC8
Organism: Saccharomyces cerevisiae
Length: 578 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAC8.

Description E-value Query
Range		 Subject
Range
gi|190405552 - gi|190405552|gb|EDV08819.1| vacuolar protein 8 [Saccharomyces cerevisiae RM11-1a]
VAC8 - Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for ...
VAC8_YEAST - Vacuolar protein 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VAC8 PE=1 SV=3
 4.0E-91 [1..578] [1..578]
gi|85098694 - gi|85098694|ref|XP_960652.1| importin alpha subunit [Neurospora crassa OR74A]
gi|32412524, gi|... - gi|32412524|ref|XP_326742.1| probable importin alpha SRP1 [MIPS] [Neurospora crassa], gi|28922164|gb...
 2.0E-83 [128..554] [83..525]
CTNB_TRIGR - Catenin beta OS=Tripneustes gratilla PE=2 SV=1
 5.0E-83 [3..572] [206..748]
gi|18448958 - gi|18448958|gb|AAL69976.1|AF465210_1 karyopherin alpha [Emericella nidulans]
KAPA_EMENI - Importin subunit alpha OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /...
 2.0E-82 [114..544] [69..515]
gi|2982185 - gi|2982185|gb|AAC06340.1| beta-catenin [Lytechinus variegatus]
 2.0E-81 [3..572] [207..749]
gi|17940120 - gi|17940120|gb|AAL49497.1|AF408420_1 beta-catenin [Chaetopterus variopedatus]
 3.0E-81 [3..562] [207..753]
gi|109001083 - gi|109001083|ref|XP_001102387.1| PREDICTED: karyopherin alpha 6 isoform 7 [Macaca mulatta]
gi|114555289 - gi|114555289|ref|XP_513276.2| PREDICTED: karyopherin alpha 6 isoform 2 [Pan troglodytes]
gi|123981368, gi... - gi|61360043|gb|AAX41803.1| karyopherin alpha 6 [synthetic construct], gi|61360037|gb|AAX41802.1| kar...
IMA7_PONAB - Importin subunit alpha-7 OS=Pongo abelii GN=KPNA6 PE=2 SV=1
KPNA6 - karyopherin alpha 6 (importin alpha 7)
gi|55728015 - gi|55728015|emb|CAH90760.1| hypothetical protein [Pongo abelii]
 5.0E-81 [92..558] [46..530]
gi|156619752 - gi|156619752|gb|ABU88472.1| beta-catenin [Anser anser]
gi|2511456, gi|4... - gi|46048792|ref|NP_990412.1| catenin (cadherin-associated protein), beta 1, 88kDa [Gallus gallus], g...
 1.0E-80 [5..560] [192..729]
CTNB1_RAT - Catenin beta-1 OS=Rattus norvegicus GN=Ctnnb1 PE=1 SV=1
 3.0E-79 [5..560] [192..729]
gi|82547204, gi|... - gi|82547204|gb|ABB82357.1| beta catenin 1 [Equus caballus], gi|170287751|ref|NP_001116234.1| catenin...
gi|47523792, gi|... - gi|47523792|ref|NP_999532.1| catenin (cadherin-associated protein), beta 1, 88kDa [Sus scrofa], gi|1...
CTNB1_BOVIN - Catenin beta-1 OS=Bos taurus GN=CTNNB1 PE=1 SV=1
CTNB1_CANLF - Catenin beta-1 OS=Canis lupus familiaris GN=CTNNB1 PE=1 SV=1
 4.0E-79 [5..560] [192..729]

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Predicted Domain #1
Region A:
Residues: [1-86] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSCCSCLKD SSDEASVSPI ADNEREAVTL LLGYLEDKDQ LDFYSGGPLK ALTTLVYSDN  60
   61 LNLQRSAALA FAEITEKYVR QVSREV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 3bct__
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.09219467906677 bayes_pls_golite062009
binding 2.48958374349477 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.01243877392722 bayes_pls_golite062009
protein binding 1.94427330399472 bayes_pls_golite062009
clathrin binding 1.82663703481803 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
protein transmembrane transporter activity 1.27438167414302 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.851483195437252 bayes_pls_golite062009
nuclear localization sequence binding 0.661470469730249 bayes_pls_golite062009
hydrolase activity 0.610187344532862 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
primary active transmembrane transporter activity 0.00492507437049428 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [87-204] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEPILILLQS QDPQIQVAAC AALGNLAVNN ENKLLIVEMG GLEPLINQMM GDNVEVQCNA  60
   61 VGCITNLATR DDNKHKIATS GALIPLTKLA KSKHIRVQRN ATGALLNMTH SEENRKEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 3bct__
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [205-293] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNAGAVPVLV SLLSSTDPDV QYYCTTALSN IAVDEANRKK LAQTEPRLVS KLVSLMDSPS  60
   61 SRVKCQATLA LRNLASDTSY QLEIVRAGG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 3bct__
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [294-334] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPHLVKLIQS DSIPLVLASV ACIRNISIHP LNEGLIVDAG F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 3bct__
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [335-441] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPLVRLLDY KDSEEIQCHA VSTLRNLAAS SEKNRKEFFE SGAVEKCKEL ALDSPVSVQS  60
   61 EISACFAILA LADVSKLDLL EANILDALIP MTFSQNQEVS GNAAAAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 123.0
Match: 3bct__
Description: beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [442-578] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANLCSRVNNY TKIIEAWDRP NEGIRGFLIR FLKSDYATFE HIALWTILQL LESHNDKVED  60
   61 LVKNDDDIIN GVRKMADVTF ERLQRSGIDV KNPGSNNNPS SNDNNSNNND TGSEHQPVED 120
  121 ASLELYNITQ QILQFLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 194.28043
Match: 1bk6A_
Description: Karyopherin alpha
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle