YRC Public Data Repository - Protein Structure Prediction

Protein:	PAD1
Organism:	Saccharomyces cerevisiae
Length:	242 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PAD1.

Description	E-value	Query Range	Subject Range
gi\|393285 - gi\|393285\|gb\|AAA20484.1\| phenylacrylic acid decarboxylase [Saccharomyces cerevisiae]	3.0E-80	[1..242]	[1..242]
gi\|213161739 - gi\|213161739\|ref\|ZP_03347449.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|25299170, gi\|... - gi\|25299170\|pir\|\|AD0855 probable decarboxylase [imported] - Salmonella enterica subsp. enterica sero... gi\|214003230 - gi\|214003230\|ref\|ZP_03413965.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213857775 - gi\|213857775\|ref\|ZP_03384746.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|29143177, gi\|... - gi\|29143177\|ref\|NP_806519.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str. T... gi\|213648324 - gi\|213648324\|ref\|ZP_03378377.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|16761693 - gi\|16761693\|ref\|NP_457310.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str. C... gi\|213425681 - gi\|213425681\|ref\|ZP_03358431.1\| decarboxylase [Salmonella enterica subsp. enterica serovar Typhi str...	2.0E-58	[56..240]	[2..187]
PADL_BACSU - Probable UbiX-like flavin prenyltransferase OS=Bacillus subtilis (strain 168) GN=bsdB PE=1 SV=1 gi\|221317435 - gi\|221317435\|ref\|ZP_03598729.1\| aromatic acid decarboxylase [Bacillus subtilis subsp. subtilis str. ... gi\|221312499 - gi\|221312499\|ref\|ZP_03594304.1\| aromatic acid decarboxylase [Bacillus subtilis subsp. subtilis str. ... gi\|221321697 - gi\|221321697\|ref\|ZP_03602991.1\| aromatic acid decarboxylase [Bacillus subtilis subsp. subtilis str. ... BSDB_BACSU, PAAD... - Probable aromatic acid decarboxylase OS=Bacillus subtilis GN=yclB PE=3 SV=1, Phenolic acid decarboxy...	2.0E-58	[53..242]	[11..200]
gi\|168774728, gi... - gi\|187769605\|gb\|EDU33449.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|189362054, gi... - gi\|189362054\|gb\|EDU80473.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|189372223, gi... - gi\|189372223\|gb\|EDU90639.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|168778722, gi... - gi\|189003454\|gb\|EDU72440.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|168749935, gi... - gi\|188015767\|gb\|EDU53889.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|168762861, gi... - gi\|189366873\|gb\|EDU85289.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|189357352, gi... - gi\|189357352\|gb\|EDU75771.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|15832847, gi\|... - gi\|15832847\|ref\|NP_311620.1\| putative phenylacrylic acid decarboxylase [Escherichia coli O157:H7 str... gi\|209159006, gi... - gi\|209397606\|ref\|YP_002272202.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H... gi\|208820709, gi... - gi\|208820709\|ref\|ZP_03261029.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7... gi\|217327877, gi... - gi\|217327877\|ref\|ZP_03443960.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7... gi\|25299158, gi\|... - gi\|4887557\|emb\|CAB43500.1\| phenylacrylic acid decarboxylase-like protein [Escherichia coli], pir\|\|A9... gi\|195938490 - gi\|195938490\|ref\|ZP_03083872.1\| putative phenylacrylic acid decarboxylase [Escherichia coli O157:H7 ... PADL_ECO57 - Probable UbiX-like flavin prenyltransferase OS=Escherichia coli O157:H7 GN=ecdB PE=1 SV=1 gi\|168800180, gi... - gi\|189377463\|gb\|EDU95879.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7 str... gi\|208734592, gi... - gi\|208813315\|ref\|ZP_03254644.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7... gi\|208728143, gi... - gi\|208808342\|ref\|ZP_03250679.1\| 4-hydroxybenzoate decarboxylase, subunit B [Escherichia coli O157:H7... gi\|254794679, gi... - gi\|254794679\|ref\|YP_003079516.1\| putative decarboxylase [Escherichia coli O157:H7 str. TW14359], gi\|...	3.0E-58	[56..239]	[2..186]
gi\|25299162 - gi\|25299162\|pir\|\|B85923 probable decarboxylase Z4047 [imported] - Escherichia coli (strain O157:H7,... gi\|15803256, gi\|... - gi\|15803256\|ref\|NP_289288.1\| putative decarboxylase [Escherichia coli O157:H7 EDL933], gi\|12517190\|g...	6.0E-58	[56..239]	[2..186]
gi\|205328721, gi... - gi\|205328721\|gb\|EDZ15485.1\| 4-hydroxybenzoate decarboxylase, subunit B [Salmonella enterica subsp. e... gi\|168261951, gi... - gi\|205349076\|gb\|EDZ35707.1\| 4-hydroxybenzoate decarboxylase, subunit B [Salmonella enterica subsp. e... lcl\|NC_016856.1_... - [gene=STM14_3523] [protein=putative flavoprotein] [protein_id=YP_005239032.1] [location=3083419..308... gi\|16766227, gi\|... - gi\|16766227\|ref\|NP_461842.1\| putative flavoprotein [Salmonella typhimurium LT2], gi\|16421470\|gb\|AAL2... gi\|199603741, gi... - gi\|200386643\|ref\|ZP_03213255.1\| 4-hydroxybenzoate decarboxylase, subunit B [Salmonella enterica subs... gi\|194403613, gi... - gi\|194444950\|ref\|YP_002042162.1\| 4-hydroxybenzoate decarboxylase, subunit B [Salmonella enterica sub... gi\|197262120, gi... - gi\|197262120\|ref\|ZP_03162194.1\| 4-hydroxybenzoate decarboxylase, subunit B [Salmonella enterica subs...	2.0E-57	[56..240]	[2..187]
gi\|194431624, gi... - gi\|194431624\|ref\|ZP_03063915.1\| 4-hydroxybenzoate decarboxylase, subunit B [Shigella dysenteriae 101... gi\|218362055, gi... - gi\|218555287\|ref\|YP_002388200.1\| conserved putative non-oxidative reversible hydroxyarylic acid deca... gi\|209913441, gi... - gi\|209920182\|ref\|YP_002294266.1\| putative phenylacrylic acid decarboxylase [Escherichia coli SE11], ... gi\|218696337, gi... - gi\|218696337\|ref\|YP_002404004.1\| conserved putative non-oxidative reversible hydroxyarylic acid deca... gi\|24053156, gi\|... - gi\|24114034\|ref\|NP_708544.1\| phenylacrylic acid decarboxylase-like protein [Shigella flexneri 2a str... gi\|30042353, gi\|... - gi\|30064097\|ref\|NP_838268.1\| phenylacrylic acid decarboxylase-like protein [Shigella flexneri 2a str... gi\|193064989, gi... - gi\|75256945\|ref\|ZP_00728521.1\| COG0163: 3-polyprenyl-4-hydroxybenzoate decarboxylase [Escherichia co... gi\|190903175, gi... - gi\|75230050\|ref\|ZP_00716560.1\| COG0163: 3-polyprenyl-4-hydroxybenzoate decarboxylase [Escherichia co... PADL_ECOLX - Probable UbiX-like flavin prenyltransferase OS=Escherichia coli GN=ecdB PE=3 SV=1	2.0E-57	[56..239]	[2..186]
gi\|17932861 - gi\|17932861\|emb\|CAD19469.1\| putative Pad1 protein [Kluyvera cryocrescens]	3.0E-57	[56..242]	[2..189]

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Predicted Domain #1

Region A:
Residues: [1-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLFPRRTNI AFFKTTGIFA NFPLLGRTIT TSPSFLTHKL SKEVTRASTS PPRPKRIVVA  60
   61 ITGATGVALG IRLLQVLKEL SVETHLVISK WGAATMKYET DWEPHDVAAL ATKTYSVRDV 120
  121 SACISSGSFQ HDGMIVVPCS MKSLAAIRIG FTEDLITRAA DVSIKENRKL LLVTRETPLS 180
  181 SIHLENMLSL CRAGVIIFPP VPAFYTRPKS LHDLLEQSVG RILDCFGIHA DTFPRWEGIK 240
  241 SK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.522879
Match:	1e20A_
Description:	4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carboxy-lyase activity	1.79168084682693	bayes_pls_golite062009
catalytic activity	1.51672397362026	bayes_pls_golite062009
phosphopantothenoylcysteine decarboxylase activity	1.48487339529068	bayes_pls_golite062009
carbon-carbon lyase activity	1.47015520875054	bayes_pls_golite062009
phosphopantothenate--cysteine ligase activity	0.202735745322414	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: