YRC Public Data Repository - Protein Structure Prediction

Protein:	YDR415C
Organism:	Saccharomyces cerevisiae
Length:	374 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDR415C.

Description	E-value	Query Range	Subject Range
YD415_YEAST - Probable aminopeptidase YDR415C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDR415C ... YDR415C - Putative protein of unknown function	5.0E-81	[1..374]	[1..374]
gi\|11354407 - pir\|\|C82414 aminopeptidase VCA0813 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|15601568, gi\|... - gi\|9658240\|gb\|AAF96711.1\| aminopeptidase [Vibrio cholerae O1 biovar eltor str. N16961], gi\|15601568\|... gi\|227011521, gi... - gi\|227812379\|ref\|YP_002812389.1\| aminopeptidase [Vibrio cholerae M66-2], gi\|227011521\|gb\|ACP07732.1\|... gi\|229506034, gi... - gi\|229506034\|ref\|ZP_04395543.1\| bacterial leucyl aminopeptidase [Vibrio cholerae BX 330286], gi\|2293... gi\|125620141, gi... - gi\|75828866\|ref\|ZP_00758199.1\| COG2234: Predicted aminopeptidases [Vibrio cholerae MO10], gi\|2548499... gi\|121591155, gi... - gi\|121591155\|ref\|ZP_01678461.1\| aminopeptidase [Vibrio cholerae 2740-80], gi\|121547001\|gb\|EAX57145.1... gi\|229510110, gi... - gi\|229510110\|ref\|ZP_04399590.1\| bacterial leucyl aminopeptidase [Vibrio cholerae B33], gi\|229352555\|... gi\|75814684, gi\|... - gi\|75814684\|ref\|ZP_00745243.1\| COG2234: Predicted aminopeptidases [Vibrio cholerae V52], gi\|12172977... gi\|124117519, gi... - gi\|153224699\|ref\|ZP_01954557.1\| aminopeptidase [Vibrio cholerae MAK 757], gi\|124117519\|gb\|EAY36262.1... gi\|229517760, gi... - gi\|229517760\|ref\|ZP_04407205.1\| bacterial leucyl aminopeptidase [Vibrio cholerae RC9], gi\|229345796\|... gi\|124121764, gi... - gi\|153802679\|ref\|ZP_01957265.1\| aminopeptidase [Vibrio cholerae MZO-3], gi\|124121764\|gb\|EAY40507.1\| ... gi\|229605565, gi... - gi\|229605565\|ref\|YP_002876269.1\| bacterial leucyl aminopeptidase [Vibrio cholerae MJ-1236], gi\|22937...	3.0E-56	[58..373]	[83..394]
gi\|1694931 - gi\|1694931\|dbj\|BAA12277.1\| aminopeptidase [Vibrio cholerae]	3.0E-54	[58..373]	[83..394]
NAALAD2 - N-acetylated alpha-linked acidic dipeptidase 2	3.0E-53	[2..371]	[203..580]
gi\|18250467 - gi\|18250467\|emb\|CAC85297.1\| aminopeptidase [Agaricus bisporus]	3.0E-51	[23..368]	[35..382]
AMPX_VIBPR - Bacterial leucyl aminopeptidase OS=Vibrio proteolyticus PE=1 SV=1	8.0E-51	[58..371]	[86..395]
FOLH1_RAT - Glutamate carboxypeptidase 2 OS=Rattus norvegicus GN=Folh1 PE=1 SV=1	1.0E-49	[2..371]	[215..592]
FOLH1_PIG - Glutamate carboxypeptidase 2 OS=Sus scrofa GN=FOLH1 PE=1 SV=1	7.0E-49	[2..371]	[214..591]

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Predicted Domain #1

Region A:
Residues: [1-79]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIQSLFVLF NVAIIAWSYP YEPLRVLQVG ENEVMEVPES EKLNLRRRGV KFFDVTKHTS  60
   61 FLPFFNKEEE PTVPTYNYP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
hydrolase activity	0.645556201396961	bayes_pls_golite062009
catalytic activity	0.632499955876158	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [80-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEISNKEVVD DSIKNIDKGS MHKNLAKFTS FYTRYYKSDH GFESAEWLAA TIANITKDIP  60
   61 QDTLTIEHFD HKEWKQYSII VRVTGSTTPE DIIIIGSHQD SINLLLPSIM AAPGADDNGS 120
  121 GTVTNMEALR LYTENFLKRG FRPNNTVEFH FYSAEEGGLL GSLDVFTAYA KQKKHVRAML 180
  181 QQDMTGYVSD PEDEHVGIVT DYTTPALTDF IKLIINSYLS IPYRDTQCGY ACSDHGSATR 240
  241 NGFPGSFVIE SEFKKTNKYI HSTMDTLDRL SLAHMAEHTK IVLGVIIELG SWSAW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	460.703922
Match:	1amp__
Description:	Aminopeptidase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: