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View Structure Prediction Details

Protein: YDR415C
Organism: Saccharomyces cerevisiae
Length: 374 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDR415C.

Description E-value Query
Range
Subject
Range
YD415_YEAST - Probable aminopeptidase YDR415C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDR415C ...
YDR415C - Putative protein of unknown function
5.0E-81 [1..374] [1..374]
gi|11354407 - pir||C82414 aminopeptidase VCA0813 [imported] - Vibrio cholerae (strain N16961 serogroup O1)
gi|15601568, gi|... - gi|9658240|gb|AAF96711.1| aminopeptidase [Vibrio cholerae O1 biovar eltor str. N16961], gi|15601568|...
gi|227011521, gi... - gi|227812379|ref|YP_002812389.1| aminopeptidase [Vibrio cholerae M66-2], gi|227011521|gb|ACP07732.1|...
gi|229506034, gi... - gi|229506034|ref|ZP_04395543.1| bacterial leucyl aminopeptidase [Vibrio cholerae BX 330286], gi|2293...
gi|125620141, gi... - gi|75828866|ref|ZP_00758199.1| COG2234: Predicted aminopeptidases [Vibrio cholerae MO10], gi|2548499...
gi|121591155, gi... - gi|121591155|ref|ZP_01678461.1| aminopeptidase [Vibrio cholerae 2740-80], gi|121547001|gb|EAX57145.1...
gi|229510110, gi... - gi|229510110|ref|ZP_04399590.1| bacterial leucyl aminopeptidase [Vibrio cholerae B33], gi|229352555|...
gi|75814684, gi|... - gi|75814684|ref|ZP_00745243.1| COG2234: Predicted aminopeptidases [Vibrio cholerae V52], gi|12172977...
gi|124117519, gi... - gi|153224699|ref|ZP_01954557.1| aminopeptidase [Vibrio cholerae MAK 757], gi|124117519|gb|EAY36262.1...
gi|229517760, gi... - gi|229517760|ref|ZP_04407205.1| bacterial leucyl aminopeptidase [Vibrio cholerae RC9], gi|229345796|...
gi|124121764, gi... - gi|153802679|ref|ZP_01957265.1| aminopeptidase [Vibrio cholerae MZO-3], gi|124121764|gb|EAY40507.1| ...
gi|229605565, gi... - gi|229605565|ref|YP_002876269.1| bacterial leucyl aminopeptidase [Vibrio cholerae MJ-1236], gi|22937...
3.0E-56 [58..373] [83..394]
gi|1694931 - gi|1694931|dbj|BAA12277.1| aminopeptidase [Vibrio cholerae]
3.0E-54 [58..373] [83..394]
NAALAD2 - N-acetylated alpha-linked acidic dipeptidase 2
3.0E-53 [2..371] [203..580]
gi|18250467 - gi|18250467|emb|CAC85297.1| aminopeptidase [Agaricus bisporus]
3.0E-51 [23..368] [35..382]
AMPX_VIBPR - Bacterial leucyl aminopeptidase OS=Vibrio proteolyticus PE=1 SV=1
8.0E-51 [58..371] [86..395]
FOLH1_RAT - Glutamate carboxypeptidase 2 OS=Rattus norvegicus GN=Folh1 PE=1 SV=1
1.0E-49 [2..371] [215..592]
FOLH1_PIG - Glutamate carboxypeptidase 2 OS=Sus scrofa GN=FOLH1 PE=1 SV=1
7.0E-49 [2..371] [214..591]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIQSLFVLF NVAIIAWSYP YEPLRVLQVG ENEVMEVPES EKLNLRRRGV KFFDVTKHTS  60
   61 FLPFFNKEEE PTVPTYNYP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.524 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.440 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.422 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.365 b.34.1 C-terminal domain of transcriptional repressors
View Download 0.364 d.15.7 Immunoglobulin-binding domains
View Download 0.317 b.40.4 Nucleic acid-binding proteins
View Download 0.316 d.74.2 C-terminal domain of arginine repressor
View Download 0.299 d.82.1 Copper amine oxidase, domain N
View Download 0.285 d.9.2 Description not found.
View Download 0.279 b.71.1 Glycosyl hydrolase domain
View Download 0.276 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.269 b.1.18 E set domains
View Download 0.256 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.249 d.217.1 SAND domain-like
View Download 0.247 a.180.1 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
View Download 0.247 d.95.2 Homing endonucleases
View Download 0.221 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.215 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.214 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.211 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.204 d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.204 c.51.1 Anticodon-binding domain of Class II aaRS

Predicted functions:

Term Confidence Notes
hydrolase activity 0.645556201396961 bayes_pls_golite062009
catalytic activity 0.632499955876158 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [80-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEISNKEVVD DSIKNIDKGS MHKNLAKFTS FYTRYYKSDH GFESAEWLAA TIANITKDIP  60
   61 QDTLTIEHFD HKEWKQYSII VRVTGSTTPE DIIIIGSHQD SINLLLPSIM AAPGADDNGS 120
  121 GTVTNMEALR LYTENFLKRG FRPNNTVEFH FYSAEEGGLL GSLDVFTAYA KQKKHVRAML 180
  181 QQDMTGYVSD PEDEHVGIVT DYTTPALTDF IKLIINSYLS IPYRDTQCGY ACSDHGSATR 240
  241 NGFPGSFVIE SEFKKTNKYI HSTMDTLDRL SLAHMAEHTK IVLGVIIELG SWSAW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 460.703922
Match: 1amp__
Description: Aminopeptidase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle