YRC Public Data Repository - Protein Structure Prediction

Protein:	DFM1
Organism:	Saccharomyces cerevisiae
Length:	341 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DFM1.

Description	E-value	Query Range	Subject Range
DFM1 - ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD o... gi\|190404655 - gi\|190404655\|gb\|EDV07922.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] DFM1_YEAST - DER1-like family member protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DFM1 P...	9.0E-86	[1..341]	[1..341]
RBL15_ARATH - Rhomboid-like protein 15 OS=Arabidopsis thaliana GN=RBL15 PE=1 SV=2	2.0E-57	[23..338]	[15..307]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-57	[23..338]	[15..315]
gi\|19074992, gi\|... - gi\|19074992\|ref\|NP_586498.1\| ENDOPLASMIC RETICULUM MEMBRANE PROTEIN DEGRADING MISFOLDED ER LUMINAL P... gi\|19074992 - ref\|NP_586498.1\| ENDOPLASMIC RETICULUM MEMBRANE PROTEIN DEGRADING MISFOLDED ER LUMINAL PROTEINS [Enc...	2.0E-47	[28..323]	[17..274]
DERL2_MOUSE - Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 gi\|149053255, gi... - gi\|149053255\|gb\|EDM05072.1\| rCG34415, isoform CRA_c [Rattus norvegicus], gi\|109491204\|ref\|XP_0010799...	2.0E-40	[27..292]	[10..238]
gi\|220949568, gi... - gi\|220958434\|gb\|ACL91760.1\| CG14899-PA [synthetic construct], gi\|220949568\|gb\|ACL87327.1\| CG14899-PA... CG14899-PA - This gene is referred to in FlyBase by the symbol Dmel\CG14899 (CG14899, FBgn0038438). It is a prote...	3.0E-39	[23..281]	[4..234]
gi\|162462697, gi... - gi\|9187743\|emb\|CAB97005.1\| putative NADH oxidoreductase [Zea mays], gi\|162462697\|ref\|NP_001105128.1\|...	1.0E-36	[20..291]	[17..257]

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Predicted Domain #1

Region A:
Residues: [1-267]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGPRNVRTL HGNGGRNNDV MGPKEFWLNI PPITRTLFTL AIVMTIVGRL NLINPWYFIY  60
   61 VWNLTFKKVQ IWRLLTSCVM LSSRAMPALM ELYSIYDRSS QLERGHFGPG LSNRRGPMVT 120
  121 VDYAYYLCFC ILAITTATTI IYGSYYPVVL TSGFISCITY TWSIDNANVQ IMFYGLIPVW 180
  181 GKYFPLIQLF ISFVFNEGDF VISLIGFTTG YLYTCLDTHT LGPIWGMISR KADPTYGISP 240
  241 NGKFSTPWWF TSLYARITGA HNETATF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [268-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNFANVPSS QRETRTFSGR GQRLGTAPAT LSQTSGTDSG RASGSQLRSG PSNLNQFQGR  60
   61 GQRVGQTNSP SDSQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.27938828612061	bayes_pls_golite062009
protein binding	1.72968950672856	bayes_pls_golite062009
GTPase regulator activity	0.172760623576326	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.156922202244152	bayes_pls_golite062009
enzyme regulator activity	0.0437862640556833	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: