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View Structure Prediction Details

Protein: HIM1
Organism: Saccharomyces cerevisiae
Length: 414 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIM1.

Description E-value Query
Range
Subject
Range
HIM1 - Protein of unknown function involved in DNA repair
gi|151942292 - gi|151942292|gb|EDN60648.1| high induced mutagenesis protein [Saccharomyces cerevisiae YJM789]
HIM1_YEAST - Protein HIM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIM1 PE=4 SV=1
0.0 [1..414] [1..414]

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Predicted Domain #1
Region A:
Residues: [1-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYSVNTFTD YVLLFGSSSL VGKGILENLL DINLYIKNVS DLQGKLDSLS EIKGNVVLNK  60
   61 HVFCVNRRCI NEEKSFMKTI DYINMRSVTW QGGRYYLRSR KEKDTEKVPS SPNTFCYDNF 120
  121 EEGFIKNTPE ERGKDGYSFV YNQKQFSYTL HYACGKEKGI EIICNFTVTQ LIIPRSETWP 180
  181 KLLPRIFSGT QKLEKFDIDN KNYVPGRSLP SLCDISTMVC SLGSTSARVR RTQVPSSFAD 240
  241 YYLPFNLAQE FTNTTNKRLV VTTAFNNDFL SKTFEYFRIK AKLENDLDEA LPNKLKELVI 300
  301 LRPGPMCGQH GNPINVELGK ENSTFLEKIF YYPHYLLVYK KKYISEARRI GLRTKLSEII 360
  361 ASSIYRMPGS ALLGYAVPVS KVSYVASLMA IERKSKEAGP KLEVISSYQI DMIV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVYNQKQFSY TLHYACGKEK GIEIICNFTV TQLIIPRSET WPKLLPRIFS GTQKLEKFDI  60
   61 DNKNYVPGRS LPSLCDISTM VCSLGSTSAR VRRTQVPSSF ADYYLPFNLA QEFTNTTNKR 120
  121 LVVTTAFNND FLSKTFEYFR IKAKLENDLD EALPNKLKEL VILRPGPMCG QHGNPINVEL 180
  181 GKENSTFLEK IFYYPHYLLV YKKKYISEAR RIGLRTKLSE IIASSIYRMP GSALLGYAVP 240
  241 VSKVSYVASL MAIERKSKEA GPKLEVISSY QIDMIV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.82
Match: 2fmuA
Description: Crystal structure of Tat-interacting protein 30 kDa (HIV-1 tat interactive protein 2, 30 kDa homolog) (Human) (16924205) from Mus musculus at 2.30 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.65938032155125 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle