YRC Public Data Repository - Protein Structure Prediction

Protein:	OMS1
Organism:	Saccharomyces cerevisiae
Length:	471 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OMS1.

Description	E-value	Query Range	Subject Range
gi\|207346459 - gi\|207346459\|gb\|EDZ72947.1\| YDR316Wp-like protein [Saccharomyces cerevisiae AWRI1631] OMS1_YEAST - Methyltransferase OMS1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OM... OMS1 - Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy s... gi\|151942288 - gi\|151942288\|gb\|EDN60644.1\| oxa1 multicopy suppressor [Saccharomyces cerevisiae YJM789]	0.0	[1..471]	[1..471]
gi\|2984038, gi\|1... - gi\|2984038\|gb\|AAC07580.1\| cyclopropane-fatty-acyl-phospholipid synthase [Aquifex aeolicus VF5], gi\|1... gi\|7443723 - pir\|\|F70449 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) - Aquifex aeolicus	2.0E-49	[131..447]	[68..356]
gi\|15600739, gi\|... - gi\|9951886\|gb\|AAG08931.1\|AE004967_2 conserved hypothetical protein [Pseudomonas aeruginosa PAO1], gi... gi\|11348354 - pir\|\|C82951 conserved hypothetical protein PA5546 [imported] - Pseudomonas aeruginosa (strain PAO1)	1.0E-48	[125..447]	[57..354]
gi\|11277873 - pir\|\|A81324 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) Cj1183c [similarity] - Campy... gi\|15792507, gi\|... - gi\|6968616\|emb\|CAB73437.1\| putative cyclopropane-fatty-acyl-phospholipid synthase [Campylobacter jej...	1.0E-47	[121..447]	[57..350]
gi\|25300084 - pir\|\|AF3437 cyclopropane-fatty-acyl-phospholipid synthase (EC 2.1.1.79) [imported] - Brucella melite... gi\|17983489, gi\|... - gi\|17987767\|ref\|NP_540401.1\| cyclopropane-fatty-acyl-phospholipid synthase [Brucella melitensis 16M]...	2.0E-46	[161..452]	[116..382]
FAMT_PSEPU - Probable fatty acid methyltransferase OS=Pseudomonas putida PE=3 SV=1	5.0E-46	[126..447]	[58..354]
UBIE_VIBCH - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Vibrio cholerae serotype O1 (strain ... UBIE_VIBCM - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Vibrio cholerae serotype O1 (strain ... gi\|229508366, gi... - gi\|229508366\|ref\|ZP_04397870.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vib... gi\|229346129, gi... - gi\|229517066\|ref\|ZP_04406512.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vib... gi\|229520118, gi... - gi\|229520118\|ref\|ZP_04409546.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vib... gi\|229527169, gi... - gi\|229527169\|ref\|ZP_04416563.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vib... gi\|229369296, gi... - gi\|229606641\|ref\|YP_002877289.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vi... gi\|121587669, gi... - gi\|121587669\|ref\|ZP_01677432.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... gi\|124115249, gi... - gi\|153214643\|ref\|ZP_01949519.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... gi\|254851469, gi... - gi\|75829374\|ref\|ZP_00758679.1\| COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [V... gi\|153222877, gi... - gi\|153222877\|ref\|ZP_01953501.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... gi\|153801700, gi... - gi\|153801700\|ref\|ZP_01956286.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... gi\|116216422, gi... - gi\|75823221\|ref\|ZP_00752740.1\| COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [V... gi\|153818222, gi... - gi\|153818222\|ref\|ZP_01970889.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... UBIE_VIBC3 - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Vibrio cholerae serotype O1 (strain ... gi\|126520347, gi... - gi\|229508952\|ref\|ZP_04398442.1\| ubiquinone/menaquinone biosynthesis methyltransferase UbiE/COQ5 [Vib... gi\|121727801, gi... - gi\|75816414\|ref\|ZP_00746885.1\| COG2226: Methylase involved in ubiquinone/menaquinone biosynthesis [V... gi\|254291829, gi... - gi\|254291829\|ref\|ZP_04962613.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... gi\|153829106, gi... - gi\|153829106\|ref\|ZP_01981773.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c... UBIE_VIBCH - Ubiquinone/menaquinone biosynthesis methyltransferase ubiE OS=Vibrio cholerae GN=ubiE PE=3 SV=1 gi\|149739586, gi... - gi\|153826648\|ref\|ZP_01979315.1\| ubiquinone/menaquinone biosynthesis methlytransferase UbiE [Vibrio c...	4.0E-45	[175..422]	[12..259]
gi\|1061040, gi\|1... - gi\|1587694\|prf\|\|2207220A sterol C-methyltransferase, gi\|1061040\|emb\|CAA61966.1\| sterol-C-methyltrans...	1.0E-44	[121..431]	[6..302]
UBIE_PASMU - Ubiquinone/menaquinone biosynthesis methyltransferase ubiE OS=Pasteurella multocida GN=ubiE PE=3 SV=... UBIE_PASMU - Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE OS=Pasteurella multocida (strain Pm70) ...	1.0E-44	[165..422]	[10..267]

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Predicted Domain #1

Region A:
Residues: [1-146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVFRRFPTC LLHHIRQPAS RSLLLESQRR SLSFTSYKYN SSHIDDDKSK KKLKNVFQMN  60
   61 SNRVIRKQKT KEELAKERFE EQLRSPNRFV RWGAIARSEK FSKGMTKYMI GAYVIFLIYG 120
  121 LFFTKKLFAK DKELERLLKK QEEGNA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.220	0.925	mitochondrial envelope	a.24.3	Cytochromes

Predicted Domain #2

Region A:
Residues: [147-471]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEYEALRIKE LKGKLRRRDE LKLEEYKKMQ EEGIENFDDI RVQNFDQNKL NEQILPARDT  60
   61 TNFYQEKANE YDKAINMEER VIFLGKRRKW LMKHCQGDVL EVSCGTGRNI KYLDMSRINS 120
  121 ITFLDSSENM MEITHKKFRE KFPKYKKVAF VVGKAENLVD LAEKGKPSLE NEKENQVKYD 180
  181 TIVEAFGLCS HEDPVKALNN FGKLLKPDGR IILLEHGRGQ YDFINKILDN RAERRLNTWG 240
  241 CRWNLDLGEV LDDSDLELVE EKRTHLGTTW CIVAKRKGDV KKKDELGFVE KYLQSSIRKR 300
  301 MESFEKKDDM ASKKELEPVP PVSKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	33.0
Match:	1kpiA_
Description:	CmaA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.837368219068434	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
N-methyltransferase activity	0.290696180200503	bayes_pls_golite062009
protein methyltransferase activity	0.197622476100051	bayes_pls_golite062009
DNA binding	0.11976394186826	bayes_pls_golite062009
nucleic acid binding	0.115501290464633	bayes_pls_golite062009
transcription regulator activity	0.0754824189649688	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: