YRC Public Data Repository - Protein Structure Prediction

Protein:	VPS64
Organism:	Saccharomyces cerevisiae
Length:	604 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS64.

Description	E-value	Query Range	Subject Range
gi\|190404846 - gi\|190404846\|gb\|EDV08113.1\| vacuolar protein sorting protein 64 [Saccharomyces cerevisiae RM11-1a] VPS64 - Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7... VPS64_YEAST - Vacuolar protein sorting-associated protein 64 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...	7.0E-79	[1..604]	[1..604]
gck-4 - serine\/threonine kinase status:Partially_confirmed UniProt:O17566 protein_id:CAB03829.1	4.0E-36	[7..576]	[646..1207]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1	1.0E-29	[132..603]	[929..1410]
gi\|179508, gi\|10... - sp\|P12883\|MYH7_HUMAN Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta), gi\|4557773\|ref\|NP...	2.0E-28	[110..604]	[1376..1884]
MYH7_MOUSE - Myosin-7 OS=Mus musculus GN=Myh7 PE=1 SV=1	2.0E-28	[110..604]	[1376..1884]

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Predicted Domain #1

Region A:
Residues: [1-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVELEKRRRP PPQLQHSPYV RDQSNSQGMT KTPETSPPKR PMGRARSNSR SSGSRSNVDI  60
   61 DQYTIPPGLD LLPTASSPPS VHQVSQQQQL SPILANKIRS PFENQSQDQN DNSIDPTPAG 120
  121 QVTIPVEAVS PPALDELSKF QNGSTETLFR TG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [153-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPRKKHTHII ILKSLNATFE TKFLVVPFKP DGLKLGRPVT NSVNKNNSGS KRDLFSQQVR  60
   61 PDNGNFD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.921	0.288	protein targeting to vacuole	d.15.7	Immunoglobulin-binding domains

Predicted Domain #3

Region A:
Residues: [220-604]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRVLSRNHAC LSCDPTSGKI YIRDLKSSNG TFVNGVKIRQ NDVELKVGDT VDLGTDIDSK  60
   61 FEHRKISAYV EEISVIPLMN TVSDPTNLVM KKQDHTNKNN GNSTNINGIK IDRGHHNQHI 120
  121 PIRSHLKENY TEAGVTSATT AQRAAFEAAM FGDINNSELD DDILGPETEV LSGIFINNSA 180
  181 GTSINLINMI KTLTTELSLE KQELEKLHSM QNFMQNYTIN LDFINKHMID MNEKHLLKLS 240
  241 TALQKTLSEN NDALLKESED QLKEIKQQNN KVKSACSLKE KQNHEKLQEL ESELRELNLQ 300
  301 IEEERGKNLV LTQSNFNGGI NNDNNAKVKQ NDSREEKKDT EDTLISTEEL GVVEGKRTRV 360
  361 SKGMLFGVVA ISFGLVATAV KQLPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits