YRC Public Data Repository - Protein Structure Prediction

Protein:	NBP2
Organism:	Saccharomyces cerevisiae
Length:	236 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NBP2.

Description	E-value	Query Range	Subject Range
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	5.0E-48	[16..213]	[249..442]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5 gi\|210189 - gi\|210189\|gb\|AAA42565.1\| src-p60 phosphoprotein SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...	8.0E-47	[16..213]	[3..196]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-47	[16..213]	[3..196]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4	9.0E-47	[16..213]	[3..196]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...	1.0E-46	[16..213]	[3..196]
gi\|210226 - gi\|210226\|gb\|AAA42573.1\| tyrosine-specific protein kinase	3.0E-46	[16..213]	[3..196]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...	3.0E-46	[16..213]	[3..196]
gi\|190404884 - gi\|190404884\|gb\|EDV08151.1\| hypothetical protein SCRG_00361 [Saccharomyces cerevisiae RM11-1a] NBP2_YEAST - NAP1-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NBP2 PE=1 SV=1 gi\|207346644 - gi\|207346644\|gb\|EDZ73082.1\| YDR162Cp-like protein [Saccharomyces cerevisiae AWRI1631] NBP2 - Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recrui...	3.0E-46	[1..236]	[1..236]
gi\|210265 - gi\|210265\|gb\|AAA42583.1\| p66-src protein gi\|394713 - gi\|394713\|emb\|CAA36156.1\| src protein [Avian sarcoma virus] SRC_AVIS2 - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain PR2257) GN=V-SRC PE=...	4.0E-46	[16..213]	[3..196]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATMETTTQK DTNILKSGLK KTIGVLNEAV LQNGREVEAV QAGNSDTMED TETTTIGYIS  60
   61 IKDYAYADSN PLHYGYFDGD NEEDEMVSDS SNGEDTYNKR QSI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.649	d.38.1	Thioesterase/thiol ester dehydrase-isomerase
View	Download	0.588	d.110.1	Profilin (actin-binding protein)
View	Download	0.555	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.475	d.52.2	GMP synthetase C-terminal dimerisation domain
View	Download	0.436	d.237.1	Hypothetical protein YjiA, C-terminal domain
View	Download	0.422	d.17.1	Cystatin/monellin
View	Download	0.416	c.30.1	PreATP-grasp domain
View	Download	0.413	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.405	d.58.13	Anticodon-binding domain of PheRS
View	Download	0.398	d.58.12	eEF-1beta-like
View	Download	0.394	c.47.1	Thioredoxin-like
View	Download	0.391	d.17.1	Cystatin/monellin
View	Download	0.379	b.101.1	Ribonuclease domain of colicin E3
View	Download	0.372	d.199.1	DNA-binding C-terminal domain of the transcription factor MotA
View	Download	0.363	d.81.1	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View	Download	0.363	d.58.7	RNA-binding domain, RBD
View	Download	0.348	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.346	d.93.1	SH2 domain
View	Download	0.343	d.81.1	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View	Download	0.332	b.55.1	PH domain-like
View	Download	0.332	a.24.16	Nucleotidyltransferase substrate binding subunit/domain
View	Download	0.328	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.327	b.55.1	PH domain-like
View	Download	0.316	d.17.2	Copper amine oxidase, domains 1 and 2
View	Download	0.305	d.13.1	HIT-like
View	Download	0.304	d.28.1	Ribosomal protein S19
View	Download	0.293	a.143.1	RNA polymerase omega subunit
View	Download	0.290	d.218.1	Nucleotidyltransferase
View	Download	0.288	c.47.1	Thioredoxin-like
View	Download	0.281	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore
View	Download	0.279	d.24.1	Pili subunits
View	Download	0.269	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.257	d.50.2	Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View	Download	0.255	c.23.1	CheY-like
View	Download	0.248	d.38.1	Thioesterase/thiol ester dehydrase-isomerase
View	Download	0.246	d.233.1	Inhibitor of vertebrate lysozyme, Ivy
View	Download	0.245	d.24.1	Pili subunits
View	Download	0.242	c.47.1	Thioredoxin-like
View	Download	0.236	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.230	b.60.1	Lipocalins
View	Download	0.228	d.134.1	Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View	Download	0.225	b.60.1	Lipocalins
View	Download	0.219	b.60.1	Lipocalins
View	Download	0.217	d.227.1	OsmC-like

Predicted functions:

Term	Confidence	Notes
binding	3.12724619324809	bayes_pls_golite062009
protein binding	2.14586566310919	bayes_pls_golite062009
transcription regulator activity	1.38649262176488	bayes_pls_golite062009
nucleic acid binding	1.28138694351561	bayes_pls_golite062009
DNA binding	1.17144894382542	bayes_pls_golite062009
protein kinase activity	0.688121376464754	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.672113434569322	bayes_pls_golite062009
molecular adaptor activity	0.657981592359252	bayes_pls_golite062009
kinase activity	0.613339968424942	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.57798177622409	bayes_pls_golite062009
transcription factor activity	0.573315212617741	bayes_pls_golite062009
SH3/SH2 adaptor activity	0.559549509453052	bayes_pls_golite062009
protein binding, bridging	0.370788151516215	bayes_pls_golite062009
signal transducer activity	0.150891693412241	bayes_pls_golite062009
molecular transducer activity	0.150891693412241	bayes_pls_golite062009
kinase regulator activity	0.10704587503284	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [104-166]

      1          11         21         31         41         51         
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    1 TLPDDYIVNQ RAVALYDFEP ENDNELRLAE GDIVFISYKH GQGWLVAENE SGSKTGLVPE  60
   61 EFV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1qlyA_
Description:	Bruton's tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [167-236]

      1          11         21         31         41         51         
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    1 SYIQPEDGEN EVENKARPFY LTHLITQSVS PKNNIDNTNE DEYDDNDEWE DIDDVAEVEA  60
   61 DMKTKLDISD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.09691
Match:	1aotF_
Description:	Tyrosine kinase Fyn
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: