YRC Public Data Repository - Protein Structure Prediction

Protein:	ARX1
Organism:	Saccharomyces cerevisiae
Length:	593 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARX1.

Description	E-value	Query Range	Subject Range
ARX1_YEAST - Probable metalloprotease ARX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARX1 PE=1 ... gi\|190404935 - gi\|190404935\|gb\|EDV08202.1\| hypothetical protein SCRG_00415 [Saccharomyces cerevisiae RM11-1a] ARX1 - Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interact...	0.0	[1..593]	[1..593]
gi\|11264611 - pir\|\|E82845 methionine aminopeptidase XF0111 [imported] - Xylella fastidiosa (strain 9a5c) gi\|9104893, gi\|1... - gi\|9104893\|gb\|AAF82924.1\|AE003865_1 methionine aminopeptidase [Xylella fastidiosa 9a5c], gi\|15836716...	7.0E-67	[18..327]	[5..254]
MAP1A_ARATH - Methionine aminopeptidase 1A OS=Arabidopsis thaliana GN=MAP1A PE=1 SV=1	2.0E-65	[8..336]	[130..396]
gi\|9257170 - gi\|9257170\|pdb\|4MAT\|A Chain A, E.Coli Methionine Aminopeptidase His79ala Mutant	7.0E-64	[19..346]	[5..272]
gi\|11264640 - pir\|\|E82029 methionyl aminopeptidase (EC 3.4.11.18) NMA0337 [imported] - Neisseria meningitidis (str... gi\|15793347, gi\|... - gi\|7379091\|emb\|CAB83640.1\| methionine aminopeptidase [Neisseria meningitidis Z2491], gi\|218767339\|re... gi\|121635748, gi... - gi\|121635748\|ref\|YP_975993.1\| methionine aminopeptidase [Neisseria meningitidis FAM18], gi\|120867454...	1.0E-63	[19..326]	[6..254]
gi\|11264644 - pir\|\|C81008 methionine aminopeptidase NMB2093 [imported] - Neisseria meningitidis (strain MC58 serog... gi\|15677913, gi\|... - gi\|7227355\|gb\|AAF42410.1\| methionine aminopeptidase [Neisseria meningitidis MC58], gi\|15677913\|ref\|N... gi\|254671021 - gi\|254671021\|emb\|CBA07821.1\| Methionine aminopeptidase [Neisseria meningitidis alpha153] gi\|161870963, gi... - gi\|161870963\|ref\|YP_001600143.1\| methionine aminopeptidase [Neisseria meningitidis 053442], gi\|16159... gi\|254804097, gi... - gi\|254804097\|ref\|YP_003082318.1\| Methionine aminopeptidase [Neisseria meningitidis], gi\|254667639\|em...	1.0E-63	[19..326]	[6..254]
gi\|15074661 - gi\|15074661\|emb\|CAC46306.1\| Putative methionine aminopeptidase [Sinorhizobium meliloti 1021] gi\|15965480 - gi\|15965480\|ref\|NP_385833.1\| methionine aminopeptidase [Sinorhizobium meliloti 1021]	2.0E-63	[1..335]	[1..274]
gi\|218770341, gi... - gi\|218890118\|ref\|YP_002438982.1\| methionine aminopeptidase [Pseudomonas aeruginosa LESB58], gi\|21877... gi\|116051654, gi... - gi\|32038774\|ref\|ZP_00137046.1\| COG0024: Methionine aminopeptidase [Pseudomonas aeruginosa UCBPP-PA14... gi\|107103171 - gi\|107103171\|ref\|ZP_01367089.1\| hypothetical protein PaerPA_01004240 [Pseudomonas aeruginosa PACS2] gi\|15598853, gi\|... - gi\|9949818\|gb\|AAG07045.1\|AE004785_9 methionine aminopeptidase [Pseudomonas aeruginosa PAO1], gi\|1559... gi\|126168501, gi... - gi\|84319638\|ref\|ZP_00968032.1\| COG0024: Methionine aminopeptidase [Pseudomonas aeruginosa C3719], gi... gi\|11350595 - pir\|\|D83189 methionine aminopeptidase PA3657 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|126195732, gi... - gi\|84325378\|ref\|ZP_00973413.1\| COG0024: Methionine aminopeptidase [Pseudomonas aeruginosa 2192], gi\|...	5.0E-63	[18..328]	[4..253]
gi\|91070811, gi\|... - gi\|91209237\|ref\|YP_539223.1\| methionine aminopeptidase [Escherichia coli UTI89], gi\|91070811\|gb\|ABE0... gi\|15829424, gi\|... - gi\|15829424\|ref\|NP_308197.1\| methionine aminopeptidase [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|110341979, gi... - gi\|110640387\|ref\|YP_668115.1\| methionine aminopeptidase [Escherichia coli 536], gi\|110341979\|gb\|ABG6... gi\|117622453, gi... - gi\|117622453\|ref\|YP_851366.1\| methionine aminopeptidase [Escherichia coli APEC O1], gi\|115511577\|gb\|... gi\|124499764, gi... - gi\|124529608\|ref\|ZP_01700552.1\| methionine aminopeptidase, type I [Escherichia coli B], gi\|124499764... gi\|21239022, gi\|... - gi\|89107048\|ref\|AP_000828.1\| methionine aminopeptidase [Escherichia coli str. K-12 substr. W3110], g... gi\|188014584, gi... - gi\|188014584\|gb\|EDU52706.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4113]... gi\|189357080, gi... - gi\|189357080\|gb\|EDU75499.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4401]... gi\|168764326, gi... - gi\|189365634\|gb\|EDU84050.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4501]... gi\|168770360, gi... - gi\|189360721\|gb\|EDU79140.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4486]... gi\|168777004, gi... - gi\|187767689\|gb\|EDU31533.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4196]... gi\|168782059, gi... - gi\|189000394\|gb\|EDU69380.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4076]... AMPM_ECOLI - Methionine aminopeptidase (EC 3.4.11.18) (MAP) (Peptidase M) - Escherichia coli gi\|189371122, gi... - gi\|189371122\|gb\|EDU89538.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC869],... MAP1_SHIFL - Methionine aminopeptidase OS=Shigella flexneri GN=map PE=3 SV=1 gi\|189375674, gi... - gi\|189375674\|gb\|EDU94090.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC508],... gi\|24050369, gi\|... - gi\|24111603\|ref\|NP_706113.1\| methionine aminopeptidase [Shigella flexneri 2a str. 301], gi\|24050369\|... gi\|254791301, gi... - gi\|254791301\|ref\|YP_003076138.1\| methionine aminopeptidase [Escherichia coli O157:H7 str. TW14359], ... MAP1_ECOL6 - Methionine aminopeptidase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=map PE=3... gi\|253972188, gi... - gi\|254160287\|ref\|YP_003043395.1\| methionine aminopeptidase [Escherichia coli B str. REL606], gi\|2539... gi\|30039967, gi\|... - gi\|30061725\|ref\|NP_835896.1\| methionine aminopeptidase [Shigella flexneri 2a str. 2457T], gi\|3003996... gi\|254037587, gi... - gi\|254037587\|ref\|ZP_04871664.1\| methionine aminopeptidase [Escherichia sp. 1_1_43], gi\|226840693\|gb\|... MAP1_ECO57 - Methionine aminopeptidase OS=Escherichia coli O157:H7 GN=map PE=3 SV=1 gi\|253774805, gi... - gi\|254287090\|ref\|YP_003052838.1\| methionine aminopeptidase [Escherichia coli BL21(DE3)], gi\|25397639... EG10570 - methionine aminopeptidase / Methionine aminopeptidase gi\|251783727, gi... - gi\|251783727\|ref\|YP_002998031.1\| hypothetical protein B21_00165 [Escherichia coli BL21], gi\|24237600... gi\|12512890, gi\|... - gi\|15799850\|ref\|NP_285862.1\| methionine aminopeptidase [Escherichia coli O157:H7 EDL933], gi\|1251289... gi\|238899566, gi... - gi\|238899566\|ref\|YP_002925362.1\| methionine aminopeptidase [Escherichia coli BW2952], gi\|238861754\|g... gi\|237704327, gi... - gi\|237704327\|ref\|ZP_04534808.1\| methionine aminopeptidase [Escherichia sp. 3_2_53FAA], gi\|226902239\|... gi\|227838057, gi... - gi\|227884919\|ref\|ZP_04002724.1\| methionine aminopeptidase [Escherichia coli 83972], gi\|227838057\|gb\|... gi\|209910617, gi... - gi\|209917358\|ref\|YP_002291442.1\| methionine aminopeptidase [Escherichia coli SE11], gi\|209910617\|dbj... gi\|215485329, gi... - gi\|215485329\|ref\|YP_002327760.1\| methionine aminopeptidase [Escherichia coli O127:H6 str. E2348/69],... gi\|217321424, gi... - gi\|217325203\|ref\|ZP_03441287.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. TW1... gi\|218552747, gi... - gi\|218552747\|ref\|YP_002385660.1\| methionine aminopeptidase [Escherichia coli IAI1], gi\|218359515\|emb... gi\|218557109, gi... - gi\|218557109\|ref\|YP_002390022.1\| methionine aminopeptidase [Escherichia coli S88], gi\|218363878\|emb\|... gi\|218350364, gi... - gi\|218693632\|ref\|YP_002401299.1\| methionine aminopeptidase [Escherichia coli 55989], gi\|218350364\|em... gi\|218368573, gi... - gi\|218698587\|ref\|YP_002406216.1\| methionine aminopeptidase [Escherichia coli IAI39], gi\|218368573\|em... gi\|218430519, gi... - gi\|218703422\|ref\|YP_002410941.1\| methionine aminopeptidase [Escherichia coli UMN026], gi\|218430519\|e... gi\|170021479, gi... - gi\|170021479\|ref\|YP_001726433.1\| methionine aminopeptidase [Escherichia coli ATCC 8739], gi\|16975640... gi\|170079804, gi... - gi\|170079804\|ref\|YP_001729124.1\| methionine aminopeptidase [Escherichia coli str. K-12 substr. DH10B... gi\|170684311, gi... - gi\|170684311\|ref\|YP_001742295.1\| methionine aminopeptidase, type I [Escherichia coli SMS-3-5], gi\|17... gi\|195938151 - gi\|195938151\|ref\|ZP_03083533.1\| methionine aminopeptidase [Escherichia coli O157:H7 str. EC4024] gi\|208727727, gi... - gi\|208807926\|ref\|ZP_03250263.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4... gi\|208734336, gi... - gi\|208813059\|ref\|ZP_03254388.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4... gi\|208820614, gi... - gi\|208820614\|ref\|ZP_03260934.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC4... gi\|209398663, gi... - gi\|209398663\|ref\|YP_002268775.1\| methionine aminopeptidase, type I [Escherichia coli O157:H7 str. EC... AMPM_ECOL6 - Methionine aminopeptidase OS=Escherichia coli O6 GN=map PE=3 SV=1 EG10570 - methionine aminopeptidase / Methionine aminopeptidase gi\|75240243, gi\|... - gi\|75240243\|ref\|ZP_00724190.1\| COG0024: Methionine aminopeptidase [Escherichia coli F11], gi\|1911728... gi\|192958947, gi... - gi\|75238871\|ref\|ZP_00722853.1\| COG0024: Methionine aminopeptidase [Escherichia coli E110019], gi\|193... gi\|191166384, gi... - gi\|75230471\|ref\|ZP_00716952.1\| COG0024: Methionine aminopeptidase [Escherichia coli B7A], gi\|1911663... gi\|194413690, gi... - gi\|75210491\|ref\|ZP_00710642.1\| COG0024: Methionine aminopeptidase [Escherichia coli B171], gi\|194428... gi\|81244178, gi\|... - gi\|82542767\|ref\|YP_406714.1\| methionine aminopeptidase [Shigella boydii Sb227], gi\|81244178\|gb\|ABB64... gi\|82775558, gi\|... - gi\|82775558\|ref\|YP_401905.1\| methionine aminopeptidase [Shigella dysenteriae Sd197], gi\|81239706\|gb\|... gi\|75258843, gi\|... - gi\|75258843\|ref\|ZP_00730233.1\| COG0024: Methionine aminopeptidase [Escherichia coli E22], gi\|1930632... gi\|83569750, gi\|... - gi\|83569750\|ref\|ZP_00921200.1\| COG0024: Methionine aminopeptidase [Shigella dysenteriae 1012], gi\|19... gi\|157159633, gi... - gi\|75194378\|ref\|ZP_00704448.1\| COG0024: Methionine aminopeptidase [Escherichia coli HS], gi\|15715963... gi\|157079380, gi... - gi\|75189263\|ref\|ZP_00702530.1\| COG0024: Methionine aminopeptidase [Escherichia coli E24377A], gi\|157... gi\|187429889, gi... - gi\|75176487\|ref\|ZP_00696624.1\| COG0024: Methionine aminopeptidase [Shigella boydii BS512], gi\|187732... gi\|194439128, gi... - gi\|83585484\|ref\|ZP_00924129.1\| COG0024: Methionine aminopeptidase [Escherichia coli 101-1], gi\|19443...	1.0E-62	[19..338]	[5..264]

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Predicted Domain #1

Region A:
Residues: [1-355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALAISHEDT QILLKDKNIL QESVLNKYRT AGQIAQTALK YVTSLINDSY HSKTTQRQLT  60
   61 VPELCLLTDS FILTRLEQYY KNKVNERGIA IPTTIDIDQI SGGWCPEIDD TQNLLNWNKG 120
  121 KDSTFASSVT GTLRPGDLVK ITLGVHIDGY TSEVSHTMVI YPVDETKPIL QPTGPLLGGK 180
  181 ADAVAAAHIA METVVALLAC ALTPEKLPAS LGGTSSGITG QLIRTIVDTI ARSYNCGVVP 240
  241 GSRVRRIRRF LAGQNEGIVA EREYKGVVWT ESHQEADLLS NTDAKDLTVV DRGQSTPFTN 300
  301 VSAIPSDDFV VQSGEVYLID LKMASLEHCT KKGLVTLETV DSYTGKSHKA GELIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.69897
Match:	4matA_
Description:	Methionine aminopeptidase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [356-593]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPGAYVRDFA QTHILKLKTS RQLLTKIDKQ GVYPFKLSHL SSNFPFVHEN EEELQSLKKD  60
   61 LKSFRLGMSE ISNNYLCVES PIQIARWVPW DHILKATNPN GNLSYDATST LTLPGHELPL 120
  121 PKLGVSAIKL KSLMNSTKES ISLPVARECN TIVLCDSSVS TTDRPELLRL TGGSKTCQPS 180
  181 WIHSQHELNP QDSIVQGIFQ LATLAKDKRF GLLLKETQPM KQKSVETSNG GVEETMKM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits