YRC Public Data Repository - Protein Structure Prediction

Protein:	TGL2
Organism:	Saccharomyces cerevisiae
Length:	326 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TGL2.

Description	E-value	Query Range	Subject Range
gi\|1332597 - gi\|1332597\|emb\|CAA66637.1\| triglyceride lipase [Saccharomyces cerevisiae] gi\|151942047 - gi\|151942047\|gb\|EDN60403.1\| triglyceride lipase [Saccharomyces cerevisiae YJM789]	5.0E-80	[1..326]	[1..326]
gi\|2952336 - gi\|2952336\|gb\|AAC05510.1\| triacylglycerol lipase precursor [Pseudomonas luteola]	2.0E-44	[10..325]	[33..359]
gi\|243480 - gi\|243480\|gb\|AAC60400.1\| lipase [Pseudomonas] gi\|77815, gi\|216899 - gi\|77815\|pir\|\|JT0579 triacylglycerol lipase (EC 3.1.1.3) precursor - Pseudomonas sp, gi\|216899\|dbj\|B... gi\|10638019 - gi\|10638019\|emb\|CAC11021.1\| lipase [synthetic construct] LIP_PSES5 - Lipase OS=Pseudomonas sp. (strain KWI-56) GN=lip PE=1 SV=1	7.0E-44	[11..325]	[38..363]
gi\|576296, gi\|57... - gi\|576298\|pdb\|1TAH\|D Chain D, The Crystal Structure Of Triacylglycerol Lipase From Pseudomonas Gluma...	6.0E-43	[19..325]	[1..317]
gi\|2098520, gi\|1... - gi\|2098520\|pdb\|1CVL\| Chain , Crystal Structure Of Bacterial Lipase From Chromobacterium Viscosum A... gi\|93279260, gi\|... - gi\|93279262\|pdb\|2ES4\|B Chain B, Crystal Structure Of The Burkholderia Glumae Lipase- Specific Foldas...	6.0E-43	[19..325]	[2..318]
gi\|15600006, gi\|... - gi\|9951080\|gb\|AAG08198.1\|AE004894_4 lipase LipC [Pseudomonas aeruginosa PAO1], gi\|15600006\|ref\|NP_25... gi\|11350553 - pir\|\|G83044 lipase LipC PA4813 [imported] - Pseudomonas aeruginosa (strain PAO1)	2.0E-42	[72..325]	[33..308]
gi\|126170390, gi... - gi\|84317448\|ref\|ZP_00965893.1\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|84323527, gi\|... - gi\|84323527\|ref\|ZP_00971596.1\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|107103911 - gi\|107103911\|ref\|ZP_01367829.1\| hypothetical protein PaerPA_01004982 [Pseudomonas aeruginosa PACS2] gi\|53726442, gi\|... - gi\|53726442\|ref\|ZP_00141266.2\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|3550950 - gi\|3550950\|gb\|AAC34733.1\| lipase [Pseudomonas aeruginosa] gi\|218893907, gi... - gi\|218893907\|ref\|YP_002442776.1\| lipase LipC [Pseudomonas aeruginosa LESB58], gi\|218774135\|emb\|CAW29...	2.0E-42	[72..325]	[33..308]
gi\|3660409, gi\|3... - gi\|3660409\|pdb\|4LIP\|E Chain E, Pseudomonas Lipase Complexed With Rc-(Rp, Sp)-Dibutylcarbamoylglycero... gi\|3660409, gi\|1... - gi\|3660419\|pdb\|5LIP\| Chain , Pseudomonas Lipase Complexed With Rc-(Rp, Sp)-1,2-Dioctylcarbamoylgly...	4.0E-42	[67..325]	[5..319]
gi\|121549067, gi... - gi\|121586770\|ref\|ZP_01676553.1\| lactonizing lipase [Vibrio cholerae 2740-80], gi\|121549067\|gb\|EAX591... gi\|254850579, gi... - gi\|75830993\|ref\|ZP_00760262.1\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|153222359, gi... - gi\|153222359\|ref\|ZP_01953109.1\| lactonizing lipase [Vibrio cholerae MAK 757], gi\|124118996\|gb\|EAY377... gi\|153819830, gi... - gi\|153819830\|ref\|ZP_01972497.1\| lactonizing lipase [Vibrio cholerae NCTC 8457], gi\|126509630\|gb\|EAZ7... gi\|227811843, gi... - gi\|227811843\|ref\|YP_002811853.1\| lactonizing lipase [Vibrio cholerae M66-2], gi\|227010985\|gb\|ACP0719... gi\|121727755, gi... - gi\|75816524\|ref\|ZP_00746992.1\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|229510585, gi... - gi\|229510585\|ref\|ZP_04400065.1\| lipase precursor [Vibrio cholerae B33], gi\|229353030\|gb\|EEO17970.1\| ... gi\|229517284, gi... - gi\|229517284\|ref\|ZP_04406729.1\| lipase precursor [Vibrio cholerae RC9], gi\|229345320\|gb\|EEO10293.1\| ... gi\|15600990, gi\|... - gi\|9657615\|gb\|AAF96133.1\| lactonizing lipase [Vibrio cholerae O1 biovar eltor str. N16961], gi\|15600... gi\|147671929, gi... - gi\|75825742\|ref\|ZP_00755178.1\| COG1075: Predicted acetyltransferases and hydrolases with the alpha/b... gi\|229371580, gi... - gi\|229605094\|ref\|YP_002875798.1\| lipase precursor [Vibrio cholerae MJ-1236], gi\|229371580\|gb\|ACQ6200... gi\|11262200 - gi\|11262200\|pir\|\|C82486 lactonizing lipase VCA0221 [imported] - Vibrio cholerae (strain N16961 sero...	6.0E-42	[54..325]	[46..338]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNDNKANDI IIDSVKVPDS YKPPKNPIVF CHGLSGFDKL ILIPSVFHLT NLISNSIVHN  60
   61 MAENFMQDDE DKSDNKYTNL LEIEYWIGVK KFLQSKGCTV ITTKVPGFGS IEERAMALDA 120
  121 QLQKEVKKIE SKDKRHSLNL IAHSMGGLDC RYLICNIKNR NYDILSLTTI STPHRGSEMA 180
  181 DYVVDLFENL NALRVSQKIL PICFYQLTTA YMKYFNLVTP NSPKVSYFSY G

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [262-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTINSSKWGE YRGTL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [310-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILNFYLKITD DLARKGF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	175.24799
Match:	1tahB_
Description:	Lipase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity	0.716449555827534	bayes_pls_golite062009
lipase activity	0.602417432627875	bayes_pls_golite062009
carboxylesterase activity	0.535924720022784	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.100880080935406	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [232-261]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSFVPKWYNV FCTPWKIVYE RSKGCPNDGL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [277-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDMDHLDVIN WKNKLQDDWS KFFRTTTVGE KVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	175.24799
Match:	1tahB_
Description:	Lipase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: