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View Structure Prediction Details

Protein: YDR018C
Organism: Saccharomyces cerevisiae
Length: 396 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDR018C.

Description E-value Query
Range
Subject
Range
YD018_YEAST - Uncharacterized acyltransferase YDR018C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
YDR018C - Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, simila...
4.0E-91 [1..396] [1..396]
LPAT2_BRANA - 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 OS=Brassica napus GN=LPAT2 PE=2 SV=1
5.0E-72 [21..388] [3..340]
LPAT2_ARATH - 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 OS=Arabidopsis thaliana GN=LPAT2 PE=1 SV=2
3.0E-70 [21..388] [3..340]
PLCD_RAT - 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1
1.0E-68 [22..379] [10..325]
AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
6.0E-68 [22..383] [10..329]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-63 [23..390] [6..343]
CG4729-PB, CG472... - This gene is referred to in FlyBase by the symbol Dmel\CG4729 (CG4729, FBgn0036623). It is a protein...
gi|220958652 - gi|220958652|gb|ACL91869.1| CG4729-PA [synthetic construct]
2.0E-61 [15..380] [1..337]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKHSQKYRRY GIYEKTGNPF IKGLQRLLIA CLFISGSLSI VVFQICLQVL LPWSKIRFQN  60
   61 GINQSKKAFI VLLCMILNMV APSSLNVTFE TSRPLKNSSN AK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.911 a.74.1 Cyclin-like
View Download 0.822 a.7.6 Ribosomal protein S20
View Download 0.801 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.765 a.46.1 Methionine synthase domain
View Download 0.761 a.112.1 Description not found.

Predicted Domain #2
Region A:
Residues: [103-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PCFRFKDRAI IIANHQMYAD WIYLWWLSFV SNLGGNVYII LKKALQYIPL LGFGMRNFKF  60
   61 IFLSRNWQKD EKALTNSLVS MDLNARCKGP LTNYKSCYSK TNESIAAYNL IMFPEGTNLS 120
  121 LKTREKSEAF CQRAHLDHVQ LRHLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.221849
Match: 1k30A_
Description: Glycerol-3-phosphate (1)-acyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [248-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPHSKGLKFA VEKLAPSLDA IYDVTIGYSP ALRTEYVGTK FTLKKIFLMG VYPEKVDFYI  60
   61 REFRVNEIPL QDDEVFFNWL LGVWKEKDQL LEDYYNTGQF KSNAKNDNQS IVVTTQTTGF 120
  121 QHETLTPRIL SYYGFFAFLI LVFVMKKNH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.567 0.183 phospholipid biosynthetic process a.26.1 4-helical cytokines
View Download 0.538 0.040 phospholipid biosynthetic process a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.565 0.008 phospholipid biosynthetic process a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.515 0.004 phospholipid biosynthetic process a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.567 N/A N/A a.26.1 4-helical cytokines
View Download 0.565 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.548 N/A N/A a.26.1 4-helical cytokines
View Download 0.538 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.515 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.509 N/A N/A a.25.1 Ferritin-like
View Download 0.474 N/A N/A a.26.1 4-helical cytokines
View Download 0.463 N/A N/A a.7.1 Spectrin repeat
View Download 0.459 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.456 N/A N/A c.116.1 alpha/beta knot
View Download 0.456 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.427 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.414 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.384 N/A N/A a.25.1 Ferritin-like
View Download 0.367 N/A N/A a.7.1 Spectrin repeat
View Download 0.365 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.363 N/A N/A a.25.1 Ferritin-like
View Download 0.358 N/A N/A a.25.1 Ferritin-like
View Download 0.357 N/A N/A c.26.1 Nucleotidylyl transferase
View Download 0.347 N/A N/A c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.320 N/A N/A a.25.1 Ferritin-like
View Download 0.296 N/A N/A d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.293 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.290 N/A N/A c.47.1 Thioredoxin-like
View Download 0.277 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.270 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.262 N/A N/A c.98.2 HPr kinase/phoshatase HprK N-terminal domain
View Download 0.255 N/A N/A d.104.1 Class II aaRS and biotin synthetases
View Download 0.252 N/A N/A a.185.1 Gametocyte protein Pfg27
View Download 0.251 N/A N/A a.24.4 Hemerythrin
View Download 0.247 N/A N/A d.110.2 GAF domain-like
View Download 0.245 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.244 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.240 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.239 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.234 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.229 N/A N/A c.51.4 Maf/Ham1
View Download 0.217 N/A N/A a.2.7 tRNA-binding arm
View Download 0.215 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.212 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.208 N/A N/A a.24.9 alpha-catenin/vinculin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle