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View Structure Prediction Details

Protein: GCS1
Organism: Saccharomyces cerevisiae
Length: 352 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCS1.

Description E-value Query
Range
Subject
Range
GCS1 - ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares ...
GCS1_YEAST - ADP-ribosylation factor GTPase-activating protein GCS1 OS=Saccharomyces cerevisiae (strain ATCC 2045...
0.0 [1..352] [1..352]
ARFGAP1 - ADP-ribosylation factor GTPase activating protein 1
4.0E-80 [8..352] [4..332]
gi|10441356 - gi|10441356|gb|AAG17006.1|AF184146_1 ARF GAP-like zinc finger-containing protein ZIGA2 [Arabidopsis ...
3.0E-78 [12..351] [5..394]
gi|11691875 - gi|11691875|emb|CAC18721.1| ADP-ribosylation factor 1 GTPase activating protein [Mus musculus]
1.0E-75 [8..352] [4..332]
ARFG1_RAT - ADP-ribosylation factor GTPase-activating protein 1 OS=Rattus norvegicus GN=Arfgap1 PE=1 SV=1
2.0E-75 [8..352] [4..332]
Gap69C-PA - The gene GTPase-activating protein 69C is referred to in FlyBase by the symbol Dmel\Gap69C (CG4237, ...
gi|220958084, gi... - gi|220958084|gb|ACL91585.1| Gap69C-PA [synthetic construct], gi|220948710|gb|ACL86898.1| Gap69C-PA [...
3.0E-73 [8..350] [4..352]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-57 [1..284] [1..283]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDWKVDPDT RRRLLQLQKI GANKKCMDCG APNPQWATPK FGAFICLECA GIHRGLGVHI  60
   61 SFVRSITMDQ FKPEELLRME KGGNEPLTEW FKSHNIDLSL PQKVKYDNPV AEDYKEKLTC 120
  121 LCEDRVFEER EHLDFDASKL SATSQTAASA TPGVAQSREG TPLENRRSAT PANSSNGANF 180
  181 QKEKNEAYFA ELGKKNQSRP D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 187.221849
Match: 1dcqA_
Description: Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [202-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLPPSQGGKY QGFGSTPAKP PQERSAGSSN TLSLENFQAD PLGTLSRGWG LFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [255-352]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAVTKSFEDV NETVIKPHVQ QWQSGELSEE TKRAAAQFGQ KFQETSSYGF QAFSNFTKNF  60
   61 NGNAEDSSTA GNTTHTEYQK IDNNDKKNEQ DEDKWDDF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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