YRC Public Data Repository - Protein Structure Prediction

Protein:	TRM8
Organism:	Saccharomyces cerevisiae
Length:	286 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM8.

Description	E-value	Query Range	Subject Range
TRMB_YEAST - tRNA (guanine-N(7)-)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T... TRM8 - Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguan... TRMB_YEAS1 - tRNA (guanine-N(7)-)-methyltransferase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=TRM8 PE=3 SV=...	7.0E-67	[1..286]	[1..286]
CE03770 - status:Partially_confirmed UniProt:Q23126 protein_id:CAA91400.1	3.0E-52	[32..285]	[9..256]
gi\|15215058 - gi\|15215058\|gb\|AAH12649.1\| Methyltransferase like 1 [Mus musculus]	5.0E-52	[39..285]	[1..258]
gi\|1418767 - gi\|1418767\|emb\|CAA65470.1\| D1075-like [Homo sapiens]	6.0E-52	[41..285]	[15..270]
trm8 - tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 TRMB_SCHPO - tRNA (guanine-N(7)-)-methyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trm...	5.0E-48	[12..283]	[5..272]
TRMB_ARATH - tRNA (guanine-N(7)-)-methyltransferase OS=Arabidopsis thaliana GN=At5g24840 PE=2 SV=1	4.0E-46	[35..280]	[4..247]

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Predicted Domain #1

Region A:
Residues: [1-72]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAKPLSQDP GSKRYAYRIN KEENRKELKH VKINESSLVQ EGQKIDLPKK RYYRQRAHSN  60
   61 PFSDHQLEYP VS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.357	0.873	nucleus	a.4.1	Homeodomain-like
View	Download	0.250	0.873	nucleus	a.101.1	Uteroglobin-like
View	Download	0.252	0.873	nucleus	a.64.2	Bacteriocin AS-48
View	Download	0.236	0.873	nucleus	a.4.1	Homeodomain-like

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
tRNA methyltransferase activity	2.5931020126592	bayes_pls_golite062009
DNA-methyltransferase activity	2.43145108778901	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	1.53559006858264	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	1.53559006858264	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	0.720972789045101	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
RNA binding	0.417524996559564	bayes_pls_golite062009
binding	0.383237930789959	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.0858581024725429	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [73-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQDMDWSKLY PYYKNAENGQ MTKKVTIADI GCGFGGLMID LSPAFPEDLI LGMEIRVQVT  60
   61 NYVEDRIIAL RNNTASKHGF QNINVLRGNA MKFLPNFFEK GQLSKMFFCF PDPHFKQRKH 120
  121 KARIITNTLL SEYAYVLKEG GVVYTITDVK DLHEWMVKHL EEHPLFERLS KEWEENDECV 180
  181 KIMRNATEEG KKVERKKGDK FVACFTRLPT PAIL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.39794
Match:	1j4fA_
Description:	No description for 1j4fA_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: