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View Structure Prediction Details

Protein: YDL109C
Organism: Saccharomyces cerevisiae
Length: 647 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDL109C.

Description E-value Query
Range
Subject
Range
YDL109C - Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene
YD109_YEAST - Putative lipase YDL109C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YDL109C PE=1 SV=...
0.0 [1..647] [1..647]
YE7A_SCHPO - Putative lipase spac4a8.10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4A8.10 PE=2...
SPAC4A8.10 - lipase
0.0 [47..581] [108..692]
gi|21689821, gi|... - gi|51970748|dbj|BAD44066.1| unnamed protein product [Arabidopsis thaliana], gi|42561882|ref|NP_17246...
4.0E-89 [64..426] [323..750]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-81 [64..426] [323..785]
gi|28922217, gi|... - gi|32412922|ref|XP_326941.1| predicted protein [Neurospora crassa], gi|28922217|gb|EAA31464.1| conse...
gi|85098994 - gi|85098994|ref|XP_960700.1| hypothetical protein NCU06655 [Neurospora crassa OR74A]
1.0E-46 [183..435] [2..263]

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Predicted Domain #1
Region A:
Residues: [1-154]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAGRSADEV LYHNQSSVKL GELERYVITY ELYQGDSIPA DITLDSLWVK IKNTTKLSYK  60
   61 PAYLLGPFIL YCDVRAKDYE SSYKIICSAD KPVFQSNLQA QQKFIAELSL HHIKPRYVWI 120
  121 VDIVSQILFN KETKVTFEIV VGNSKASLKR KIRC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [155-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSLPDKACN ILHTGLSVHR LTTADIWKVP RPIDMSQKSH LVILTHGFQS NVSADMEYLM  60
   61 EEIYKAQMNN PNERLVIKGY MKNACETEKG IKFLGVGLAN YIIDELYDDS VGKISFIGHS 120
  121 LGGLTQTFAI CYIKTKYPYF FKKVEPINFI SLASPLLGIA TST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.39794
Match: 1hqdA_
Description: Lipase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [318-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNYVKMSLSM GIIGTTGQEL GLKDGNYGDK PLLYLLSEES LISVLARFKR RTLYANAVND  60
   61 GIVPLYSSSL LFLDYSQLLQ KLGGQTTAPC DPLFQPEVSP IGELPNHSDV ANDDDGINAS 120
  121 SWNTFWKSKE NNCDKKSKRL MNASVIKSMK SVLLSPCPDA KFFS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
hydrolase activity 1.1444670166202 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.985235528680562 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [482-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPDARVATII HDKIYTEKNL PPPSPTLYEG TAAKEGETRK TRKEMEEIIA RRWHKGMHWR  60
   61 KVVVLLKPDA HNNIIVRRRF SNAYGWPVVD HLVTAHFQRD DPIASPMQDK QFAEEDINMA 120
  121 TGGVEPNKFY SWLTKIEDPS VYHGGIVSTA SQLASSWISK HSSVTD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.234 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.229 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.399 a.63.1 Apolipophorin-III
View Download 0.311 a.24.1 Apolipoprotein
View Download 0.399 a.63.1 Apolipophorin-III
View Download 0.311 a.24.1 Apolipoprotein
View Download 0.234 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.229 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.204 d.54.1 Enolase N-terminal domain-like
View Download 0.204 d.54.1 Enolase N-terminal domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle