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View Structure Prediction Details

Protein: CDC39
Organism: Saccharomyces cerevisiae
Length: 2108 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC39.

Description E-value Query
Range
Subject
Range
NOT1_YEAST - General negative regulator of transcription subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 20450...
CDC39 - Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regu...
0.0 [1..2108] [1..2108]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..2108] [1..2108]
SPAC20G8.06 - CCR4-Not complex subunit Not1
NOT1_SCHPO - General negative regulator of transcription subunit 1 OS=Schizosaccharomyces pombe (strain 972 / ATC...
0.0 [556..2078] [625..2075]
gi|16198329 - gi|16198329|gb|AAL14011.1| SD07194p [Drosophila melanogaster]
0.0 [1451..1952] [20..557]
gi|3258569, gi|2... - gi|3258569|gb|AAC24379.1| Similar to yeast general negative regulator of transcription subunit 1 [Ar...
0.0 [543..910] [406..845]
gi|19069662, gi|... - gi|19074937|ref|NP_586443.1| NOT1-LIKE GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1 [Enceph...
gi|19074937 - gi|19074937|ref|NP_586443.1| NOT1-LIKE GENERAL NEGATIVE REGULATOR OF TRANSCRIPTION SUBUNIT 1 [Enceph...
0.0 [1353..1762] [920..1275]
gi|14165323, gi|... - gi|37536772|ref|NP_922688.1| putative transcription regulatory protein [Oryza sativa (japonica culti...
1.0E-91 [728..1270] [901..1454]

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Predicted Domain #1
Region A:
Residues: [1-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSATYRDLN TASNLETSKE KQAAQIVIAQ ISLLFTTLNN DNFESVEREI RHILDRSSVD  60
   61 IYIKVWERLL TLSSRDILQA GKFLLQENLL HRLLLEFAKD LPKKSTDLIE LLKERTFNNQ 120
  121 EFQKQTGITL SLFIDLFDKS ANKDIIESLD RSSQINDFKT IKMNHTNYLR NFFLQTTPET 180
  181 LESNLRDLLH SLEGESLNDL LALLLSEILS PGSQNLQNDP TRSWLTPPMV LDATNRGNVI 240
  241 ARSISSLQAN QINWNRVFNL MSTKYFLSAP LMPTTASLSC LFAALHDGPV IDEFFSCDWK 300
  301 VIFKLDLAIQ LHKWSVQNGC FDLLNAEGTR KVSETIPNTK QSLLYLLSIA SLNLELFLQR 360
  361 EELSDGPMLA YFQECFFEDF NYAPEYLILA LVKEMKRFVL LIENRTVIDE ILITLLIQVH 420
  421 NKSPSSFKDV ISTITDDSKI VDAAKIIINS DDAPIANFLK SLLDTGRLDT VINKLPFNEA 480
  481 FKILPCARQI GWEGFDTFLK TKVSPSNVDV VLESLEVQTK MTDTNTP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [528-754]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSLKTFDLF AFHSLIEVLN KCPLDVLQLQ RFESLEFSLL IAFPRLINFG FGHDEAILAN  60
   61 GDIAGINNDI EKEMQNYLQK MYSGELAIKD VIELLRRLRD SDLPRDQEVF TCITHAVIAE 120
  121 STFFQDYPLD ALATTSVLFG SMILFQLLRG FVLDVAFRII MRFAKEPPES KMFKFAVQAI 180
  181 YAFRIRLAEY PQYCKDLLRD VPALKSQAQV YQSIVEAATL ANAPKER

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [755-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRPVQEMIPL KFFAVDEVSC QINQEGAPKD VVEKVLFVLN NVTLANLNNK VDELKKSLTP  60
   61 NYFSWFSTYL VTQRAKTEPN YHDLYSKVIV AMGSGLLHQF MVNVTLRQLF VLLSTKDEQA 120
  121 IDKKHL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.695 a.74.1 Cyclin-like
View Download 0.557 a.29.2 Bromodomain
View Download 0.508 a.118.9 ENTH/VHS domain
View Download 0.520 d.54.1 Enolase N-terminal domain-like
View Download 0.500 a.74.1 Cyclin-like
View Download 0.489 d.54.1 Enolase N-terminal domain-like
View Download 0.459 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.454 d.55.1 Ribosomal protein L22
View Download 0.429 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.425 a.77.1 DEATH domain
View Download 0.417 a.81.1 N-terminal domain of DnaB helicase
View Download 0.411 a.77.1 DEATH domain
View Download 0.410 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.401 d.54.1 Enolase N-terminal domain-like
View Download 0.384 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.379 a.118.11 Cytochrome c oxidase subunit E
View Download 0.371 a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.357 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.352 a.118.9 ENTH/VHS domain
View Download 0.348 d.54.1 Enolase N-terminal domain-like
View Download 0.337 c.55.1 Actin-like ATPase domain
View Download 0.330 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.322 d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.305 a.85.1 Hemocyanin, N-terminal domain
View Download 0.301 a.24.11 Bacterial GAP domain
View Download 0.301 a.118.9 ENTH/VHS domain
View Download 0.298 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.297 a.118.8 TPR-like
View Download 0.296 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.296 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.294 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.293 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.290 a.133.1 Phospholipase A2, PLA2
View Download 0.285 c.55.4 Translational machinery components
View Download 0.281 a.118.8 TPR-like
View Download 0.276 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.275 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.272 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.270 a.46.1 Methionine synthase domain
View Download 0.256 d.224.1 SufE-like
View Download 0.245 a.118.8 TPR-like
View Download 0.243 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.239 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.237 d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.226 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.223 a.118.1 ARM repeat
View Download 0.221 a.29.2 Bromodomain
View Download 0.219 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.217 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.214 d.54.1 Enolase N-terminal domain-like
View Download 0.214 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.213 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.213 d.168.1 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
View Download 0.202 b.34.9 Tudor/PWWP/MBT

Predicted Domain #4
Region A:
Residues: [881-1076]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNLASWLGCI TLALNKPIKH KNIAFREMLI EAYKENRLEI VVPFVTKILQ RASESKIFKP  60
   61 PNPWTVGILK LLIELNEKAN WKLSLTFEVE VLLKSFNLTT KSLKPSNFIN TPEVIETLSG 120
  121 ALGSITLEQQ QTEQQRQIIL MQQHQQQMLI YQQRQQQQQQ RQQQQQHHIS ANTIADQQAA 180
  181 FGGEGSISHD NPFNNL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1077-1351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSTIFVTHP DLKRVFQMAL AKSVREILLE VVEKSSGIAV VTTTKIILKD FATEVDESKL  60
   61 KTAAIIMVRH LAQSLARATS IEPLKEGIRS TMQSLAPNLM SLSSSPAEEL DTAINENIGI 120
  121 ALVLIEKASM DKSTQDLADQ LMQAIAIRRY HKERRADQPF ITQNTNPYSL SLPEPLGLKN 180
  181 TGVTPQQFRV YEEFGKNIPN LDVIPFAGLP AHAPPMTQNV GLTQPQQQQA QMPTQILTSE 240
  241 QIRAQQQQQQ LQKSRLNQPS QSAQPPGVNV PNPQG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.695 a.74.1 Cyclin-like
View Download 0.557 a.29.2 Bromodomain
View Download 0.555 a.74.1 Cyclin-like
View Download 0.547 a.29.2 Bromodomain
View Download 0.539 d.54.1 Enolase N-terminal domain-like

Predicted Domain #6
Region A:
Residues: [1352-1772]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIAAVQSDLE QNQRVLVHLM DILVSQIKEN ATKNNLAELG DQNQIKTIIF QILTFIAKSA  60
   61 QKDQLALKVS QAVVNSLFAT SESPLCREVL SLLLEKLCSL SLVARKDVVW WLVYALDSRK 120
  121 FNVPVIRSLL EVNLIDATEL DNVLVTAMKN KMENSTEFAM KLIQNTVLSD DPILMRMDFI 180
  181 KTLEHLASSE DENVKKFIKE FEDTKIMPVR KGTKTTRTEK LYLVFTEWVK LLQRVENNDV 240
  241 ITTVFIKQLV EKGVISDTDN LLTFVKSSLE LSVSSFKESD PTDEVFIAID ALGSLIIKLL 300
  301 ILQGFKDDTR RDYINAIFSV IVLVFAKDHS QEGTTFNERP YFRLFSNILY EWATIRTHNF 360
  361 VRISDSSTRQ ELIEFDSVFY NTFSGYLHAL QPFAFPGFSF AWVTLLSHRM LLPIMLRLPN 420
  421 K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1773-2108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGWEKLMLLI IDLFKFLDQY TSKHAVSDAV SVVYKGTLRV ILGISNDMPS FLIENHYELM  60
   61 NNLPPTYFQL KNVILSAIPK NMTVPNPYDV DLNMEDIPAC KELPEVFFDP VIDLHSLKKP 120
  121 VDNYLRIPSN SLLRTILSAI YKDTYDIKKG VGYDFLSVDS KLIRAIVLHV GIEAGIEYKR 180
  181 TSSNAVFNTK SSYYTLLFNL IQNGSIEMKY QIILSIVEQL RYPNIHTYWF SFVLMNMFKS 240
  241 DEWNDQKLEV QEIILRNFLK RIIVNKPHTW GVSVFFTQLI NNNDINLLDL PFVQSVPEIK 300
  301 LILQQLVKYS KKYTTSEQDD QSATINRRQT PLQSNA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1079-1286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STIFVTHPDL KRVFQMALAK SVREILLEVV EKSSGIAVVT TTKIILKDFA TEVDESKLKT  60
   61 AAIIMVRHLA QSLARATSIE PLKEGIRSTM QSLAPNLMSL SSSPAEELDT AINENIGIAL 120
  121 VLIEKASMDK STQDLADQLM QAIAIRRYHK ERRADQPFIT QNTNPYSLSL PEPLGLKNTG 180
  181 VTPQQFRVYE EFGKNIPNLD VIPFAGLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1287-1382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHAPPMTQNV GLTQPQQQQA QMPTQILTSE QIRAQQQQQQ LQKSRLNQPS QSAQPPGVNV  60
   61 PNPQGGIAAV QSDLEQNQRV LVHLMDILVS QIKENA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1383-1457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKNNLAELGD QNQIKTIIFQ ILTFIAKSAQ KDQLALKVSQ AVVNSLFATS ESPLCREVLS  60
   61 LLLEKLCSLS LVARK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1458-1522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVVWWLVYAL DSRKFNVPVI RSLLEVNLID ATELDNVLVT AMKNKMENST EFAMKLIQNT  60
   61 VLSDD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1523-1709]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PILMRMDFIK TLEHLASSED ENVKKFIKEF EDTKIMPVRK GTKTTRTEKL YLVFTEWVKL  60
   61 LQRVENNDVI TTVFIKQLVE KGVISDTDNL LTFVKSSLEL SVSSFKESDP TDEVFIAIDA 120
  121 LGSLIIKLLI LQGFKDDTRR DYINAIFSVI VLVFAKDHSQ EGTTFNERPY FRLFSNILYE 180
  181 WATIRTH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [1710-1862]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFVRISDSST RQELIEFDSV FYNTFSGYLH ALQPFAFPGF SFAWVTLLSH RMLLPIMLRL  60
   61 PNKIGWEKLM LLIIDLFKFL DQYTSKHAVS DAVSVVYKGT LRVILGISND MPSFLIENHY 120
  121 ELMNNLPPTY FQLKNVILSA IPKNMTVPNP YDV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1863-2108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLNMEDIPAC KELPEVFFDP VIDLHSLKKP VDNYLRIPSN SLLRTILSAI YKDTYDIKKG  60
   61 VGYDFLSVDS KLIRAIVLHV GIEAGIEYKR TSSNAVFNTK SSYYTLLFNL IQNGSIEMKY 120
  121 QIILSIVEQL RYPNIHTYWF SFVLMNMFKS DEWNDQKLEV QEIILRNFLK RIIVNKPHTW 180
  181 GVSVFFTQLI NNNDINLLDL PFVQSVPEIK LILQQLVKYS KKYTTSEQDD QSATINRRQT 240
  241 PLQSNA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle