YRC Public Data Repository - Protein Structure Prediction

Protein:	YCL073C
Organism:	Saccharomyces cerevisiae
Length:	615 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YCL073C.

Description	E-value	Query Range	Subject Range
GEX1_YEAST - Glutathione exchanger 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEX1 PE=1 SV=4 YCL073C - Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superf...	0.0	[1..615]	[1..615]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..615]	[1..615]
gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini] gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]	8.0E-86	[14..609]	[3..602]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	1.0E-84	[26..592]	[5..539]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	7.0E-81	[49..571]	[1..500]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	8.0E-81	[48..571]	[1..501]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	1.0E-80	[48..571]	[1..501]

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Predicted Domain #1

Region A:
Residues: [1-406]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSVVGASS NKKSGIRQSC EIIERERHSN DDTYSMTSTF FKLKENEIMS AQFDSLKYKI  60
   61 LLISTAFVCG FGISLDYTLR STYTGYATNS YSEHSLLSTV QVINAVVSVG SQVVYSRLSD 120
  121 HFGRLRLFLV ATIFYIMGTI IQSQATRLTM YAAGSVFYNC GYVGTNLLLT LILSDFSSLK 180
  181 WRMFYQYASY WPYIIIPWIS GNIITAANPQ KNWSWNIAMW AFIYPLSALP IIFLILYMKY 240
  241 KSSKTAEWRS LKEQARKERT GGLFENLVFL FWKLDIVGIL LITVSLGCIL VPLTLANETS 300
  301 QKWHNSKIIA TLVSGGCLFF IFLYWEAKFA KSPLLPFKLL SDRGIWAPLG VTFFNFFTFF 360
  361 ISCDYLYPVL LVSMKESSTS AARIVNLPDF VAATASPFYS LLVAKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.39794
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.26757615356623	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [407-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKLKLSVIGG CAAWMVCMGL FYKYRGGSGS HEGVIAASVI MGLSGLLCSN SVIVILQAMT  60
   61 THSRMAVITG IQYTFSKLGA AIGASVSGAI WTQTMPNQLY KNLGNDTLAE IAYASPYTFI 120
  121 SDYPWGSPER DAVVESYRYV QRIIMTVGLA CTVPFFAFTM FMRDPELIDK ATHEEFTEDG 180
  181 LVVLPDEENI FSQIKALFRH NRSNKKLGC

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: