YRC Public Data Repository - Protein Structure Prediction

Protein:	VBA3
Organism:	Saccharomyces cerevisiae
Length:	458 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VBA3.

Description	E-value	Query Range	Subject Range
VBA3 - Permease of basic amino acids in the vacuolar membrane VBA3_YEAST - Vacuolar basic amino acid transporter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...	1.0E-63	[1..458]	[1..458]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	2.0E-59	[1..454]	[120..531]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-55	[1..442]	[136..530]
gi\|215411548 - gi\|215411548\|ref\|ZP_03420344.1\| integral membrane protein [Mycobacterium tuberculosis 94_M4241A] gi\|215403818 - gi\|215403818\|ref\|ZP_03415999.1\| integral membrane protein [Mycobacterium tuberculosis 02_1987] gi\|215430783 - gi\|215430783\|ref\|ZP_03428702.1\| integral membrane protein [Mycobacterium tuberculosis EAS054] gi\|253320582, gi... - gi\|253799079\|ref\|YP_003032080.1\| hypothetical protein TBMG_02117 [Mycobacterium tuberculosis KZN 143... gi\|215427231 - gi\|215427231\|ref\|ZP_03425150.1\| integral membrane protein [Mycobacterium tuberculosis T92] gi\|254815678 - gi\|254815678\|ref\|ZP_05220679.1\| integral membrane protein [Mycobacterium tuberculosis KZN 4207] gi\|197740515, gi... - gi\|254364698\|ref\|ZP_04980744.1\| conserved integral membrane protein [Mycobacterium tuberculosis str.... gi\|219557826 - gi\|219557826\|ref\|ZP_03536902.1\| integral membrane protein [Mycobacterium tuberculosis T17] gi\|255096662 - gi\|255096662\|ref\|ZP_05326140.1\| integral membrane protein [Mycobacterium tuberculosis KZN 605] gi\|148505835, gi... - gi\|167970360\|ref\|ZP_02552637.1\| conserved integral membrane protein [Mycobacterium tuberculosis H37R... gi\|215446069 - gi\|215446069\|ref\|ZP_03432821.1\| integral membrane protein [Mycobacterium tuberculosis T85] Y1877_MYCTO - Uncharacterized MFS-type transporter MT1926 OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh... Y1877_MYCTU - Uncharacterized MFS-type transporter Rv1877 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv... Y1877_MYCTU - Uncharacterized MFS-type transporter Rv1877/MT1926 OS=Mycobacterium tuberculosis GN=Rv1877 PE=3 SV=1 gi\|148721615, gi... - gi\|76784394\|ref\|ZP_00771579.1\| COG0477: Permeases of the major facilitator superfamily [Mycobacteriu... gi\|254232054, gi... - gi\|81254074\|ref\|ZP_00878601.1\| COG0477: Permeases of the major facilitator superfamily [Mycobacteriu...	2.0E-53	[1..444]	[115..508]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	2.0E-51	[1..440]	[102..501]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	6.0E-51	[1..440]	[102..501]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	8.0E-51	[1..440]	[101..500]

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Predicted Domain #1

Region A:
Residues: [1-336]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMLIVGRVV ASVGGSGLQT LCFVIGCTMV GERSRPLVIS ILSCAFAVAA IVGPIIGGAF  60
   61 TTHVTWRWCF YINLPIGGLA IIMFLLTYKA ENKGILQQIK DAIGTISSFT FSKFRHQVNF 120
  121 KRLMNGIIFK FDFFGFALCS AGLVLFLLGL TFGGNKYSWN SGQVIAYLVL GVLLFIFSLV 180
  181 YDFFLFDKFN PEPDNISYRP LLLRRLVAKP AIIIINMVTF LLCTGYNGQM IYSVQFFQLI 240
  241 FASSAWKAGL HLIPIVITNV IAAIASGVIT KKLGLVKPLL IFGGVLGVIG AGLMTLMTNT 300
  301 STKSTQIGVL LLPGFSLGFA LQASLMSAQL QITKDR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [337-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEAAMDFIEV TAFNTFMKSL GTTLGGVLST TVFSASFHNK VSRAHLEPYE GKTVDDMILY  60
   61 RLQNYDGSHS TIGNILSDSI KNVFWMDLGF YALGFLFCSF SSNKKLIIPK KDETPEDNLE 120
  121 DK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits