YRC Public Data Repository - Protein Structure Prediction

Protein:	KCC4
Organism:	Saccharomyces cerevisiae
Length:	1037 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KCC4.

Description	E-value	Query Range	Subject Range
KCC4_YEAST - Probable serine/threonine-protein kinase KCC4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288... KCC4 - Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, n...	0.0	[1..912]	[1..912]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..803]	[1..803]
CDPK2_ORYSJ - Calcium-dependent protein kinase isoform 2 OS=Oryza sativa subsp. japonica GN=CPK2 PE=2 SV=2 CDPK2_ORYSA - Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1) (CDPK 2) - Oryza sativa (Rice)	0.0	[2..460]	[66..512]
CDPKH_ARATH - Calcium-dependent protein kinase 17 OS=Arabidopsis thaliana GN=CPK17 PE=2 SV=1	0.0	[5..485]	[57..526]
CDPK2_MAIZE - Calcium-dependent protein kinase 2 OS=Zea mays GN=CPK2 PE=2 SV=1	0.0	[2..460]	[46..493]

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Predicted Domain #1

Region A:
Residues: [1-111]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVANTETHS AAKPSSTIGP WKLGETLGFG STGKVQLAQH ERTGHRTAVK VISKSIFNNN  60
   61 GNHSNDDSVL PYNIEREIVI MKLLSHPNVL SLYDVWETNN NLYLILEYAE K

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [310-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LADSNNHTSA SIDDSILQNL VVLWHGRHAD DIVSKLKENG TNKEKILYAL LYRFKLDSVR  60
   61 GSNKKNRNKI KKTKKNKRSS TLSSSSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	557.9897
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [112-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELFNLLVDH GPLPEREAIN CFRQIIIGIS YCHALGIVHR DLKPENLLLD SFYNIKIADF  60
   61 GMAALQTDAD LLETSCGSPH YAAPEIVSGL PYEGFASDVW SCGVILFALL TGRLPFDEEN 120
  121 GNVRDLLLKV QKGQFEMPND TEISRDAQDL IGKILVVDPR QRIKIRDILS HPLLKKYQTI 180
  181 KDSKSIKDLP RENTYLYP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	557.9897
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [397-625]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLLNNRSIQS TPRRRTSKRH SREFSSSRKR SSFLLSSNPT DSSPIPLRSS KRITHINVAS  60
   61 ANTQATPSGV PNPHKRNSKK RSSKRLSYMP NTKRSSLTSK SLSNFTNLID DDDWEYIEKD 120
  121 AKRTSSNFAT LIDEIFEPEK FELAKREKAE LQRKVQEAKR QSVNAQKINE DEFGSEVSDG 180
  181 MKELKKINDK VSSPLINYEF SQQELLQDID TLLTNRYQLS SYTRPISRL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [626-918]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPGLTPVTET LPNNLKEKTA LLQDTEKKII ETIRRSKFLG SLLNVRGGLS PGKSELAPIE  60
   61 ESPIVSTTPL IYNDRMEPRR ISDVEVPHFT RKSKHFTTAN NRRSVLSLYA KDSIKDLNEF 120
  121 LIKEDPDLPP QGSTDNESRS EDPEIAESIT DSRNIQYDED DSKDGDNVNN DNILSDFPQG 180
  181 VGISQEYDMK DKNPNQSPIS KSAEPTLVVK LPSLSSFQGK NASGLGLYQR EPSKVTLPSL 240
  241 TSNNSSVGEN IEDGAEKGTE SEKIAASLSD DDLKEDNDKK DNDTVNAPTT VKK

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.24
Match:	1iu4A
Description:	Microbial transglutaminase
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [919-1037]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPNSVLLKKF SKGKILELEI HAKIPEKRLY EGLHKLLEGW KQYGLKNLVF NITNMIITGK  60
   61 LVNDSILFLR STLFEIMVLP NGDGRSLIKF NKKTGSTKTL TKLATEIQII LQKEGVLDK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.846	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.650	0.953	axial cellular bud site selection	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.837	0.953	axial cellular bud site selection	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.702	0.953	axial cellular bud site selection	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.623	0.953	axial cellular bud site selection	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.613	0.953	axial cellular bud site selection	c.3.1	FAD/NAD(P)-binding domain
View	Download	0.575	0.953	axial cellular bud site selection	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.560	0.953	axial cellular bud site selection	b.55.1	PH domain-like
View	Download	0.532	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.531	0.953	axial cellular bud site selection	d.109.1	Actin depolymerizing proteins
View	Download	0.528	0.953	axial cellular bud site selection	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.526	0.953	axial cellular bud site selection	c.23.1	CheY-like
View	Download	0.495	0.953	axial cellular bud site selection	a.74.1	Cyclin-like
View	Download	0.489	0.953	axial cellular bud site selection	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.483	0.953	axial cellular bud site selection	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.480	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.476	0.953	axial cellular bud site selection	d.204.1	Ribosome binding protein Y (YfiA homologue)
View	Download	0.476	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.470	0.953	axial cellular bud site selection	c.53.1	Resolvase-like
View	Download	0.469	0.953	axial cellular bud site selection	d.80.1	Tautomerase/MIF
View	Download	0.468	0.953	axial cellular bud site selection	d.155.1	Pyruvoyl-dependent histidine and arginine decarboxylases
View	Download	0.460	0.953	axial cellular bud site selection	a.40.1	Calponin-homology domain, CH-domain
View	Download	0.455	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.453	0.953	axial cellular bud site selection	d.129.1	TATA-box binding protein-like
View	Download	0.446	0.953	axial cellular bud site selection	a.74.1	Cyclin-like
View	Download	0.443	0.953	axial cellular bud site selection	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.440	0.953	axial cellular bud site selection	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.435	0.953	axial cellular bud site selection	b.60.1	Lipocalins
View	Download	0.430	0.953	axial cellular bud site selection	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.424	0.953	axial cellular bud site selection	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.423	0.953	axial cellular bud site selection	d.110.1	Profilin (actin-binding protein)
View	Download	0.417	0.953	axial cellular bud site selection	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.410	0.953	axial cellular bud site selection	b.61.3	D-aminopeptidase, middle and C-terminal domains
View	Download	0.407	0.953	axial cellular bud site selection	c.13.2	Anti-sigma factor antagonist SpoIIaa
View	Download	0.402	0.953	axial cellular bud site selection	b.59.1	XRCC4, N-terminal domain
View	Download	0.397	0.953	axial cellular bud site selection	d.109.1	Actin depolymerizing proteins
View	Download	0.396	0.953	axial cellular bud site selection	b.55.1	PH domain-like
View	Download	0.393	0.953	axial cellular bud site selection	c.20.1	Initiation factor IF2/eIF5b, domain 3
View	Download	0.389	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.384	0.953	axial cellular bud site selection	b.37.1	N-terminal domains of the minor coat protein g3p
View	Download	0.382	0.953	axial cellular bud site selection	a.61.1	Retroviral matrix proteins
View	Download	0.377	0.953	axial cellular bud site selection	d.155.1	Pyruvoyl-dependent histidine and arginine decarboxylases
View	Download	0.370	0.953	axial cellular bud site selection	d.129.1	TATA-box binding protein-like
View	Download	0.369	0.953	axial cellular bud site selection	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.369	0.953	axial cellular bud site selection	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.363	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.362	0.953	axial cellular bud site selection	d.105.1	Clathrin adaptor appendage, alpha and beta chain-specific domain
View	Download	0.361	0.953	axial cellular bud site selection	a.26.1	4-helical cytokines
View	Download	0.361	0.953	axial cellular bud site selection	a.25.1	Ferritin-like
View	Download	0.358	0.953	axial cellular bud site selection	d.110.2	GAF domain-like
View	Download	0.356	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.354	0.953	axial cellular bud site selection	c.23.1	CheY-like
View	Download	0.350	0.953	axial cellular bud site selection	a.118.8	TPR-like
View	Download	0.348	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.343	0.953	axial cellular bud site selection	a.24.7	FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View	Download	0.341	0.953	axial cellular bud site selection	c.37.1	P-loop containing nucleoside triphosphate hydrolases
View	Download	0.329	0.953	axial cellular bud site selection	b.1.1	Immunoglobulin
View	Download	0.328	0.953	axial cellular bud site selection	d.110.2	GAF domain-like
View	Download	0.325	0.953	axial cellular bud site selection	b.61.4	Quinohemoprotein amine dehydrogenase A chain, domain 3
View	Download	0.323	0.953	axial cellular bud site selection	a.74.1	Cyclin-like
View	Download	0.323	0.953	axial cellular bud site selection	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.318	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.317	0.953	axial cellular bud site selection	d.233.1	Inhibitor of vertebrate lysozyme, Ivy
View	Download	0.316	0.953	axial cellular bud site selection	d.105.1	Clathrin adaptor appendage, alpha and beta chain-specific domain
View	Download	0.315	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.311	0.953	axial cellular bud site selection	b.60.1	Lipocalins
View	Download	0.310	0.953	axial cellular bud site selection	a.77.1	DEATH domain
View	Download	0.305	0.953	axial cellular bud site selection	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.300	0.953	axial cellular bud site selection	b.40.1	Staphylococcal nuclease
View	Download	0.297	0.953	axial cellular bud site selection	a.2.7	tRNA-binding arm
View	Download	0.296	0.953	axial cellular bud site selection	d.167.1	Peptide deformylase
View	Download	0.295	0.953	axial cellular bud site selection	c.47.1	Thioredoxin-like
View	Download	0.294	0.953	axial cellular bud site selection	c.47.1	Thioredoxin-like
View	Download	0.292	0.953	axial cellular bud site selection	b.1.1	Immunoglobulin
View	Download	0.288	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.287	0.953	axial cellular bud site selection	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.287	0.953	axial cellular bud site selection	c.30.1	PreATP-grasp domain
View	Download	0.285	0.953	axial cellular bud site selection	a.74.1	Cyclin-like
View	Download	0.285	0.953	axial cellular bud site selection	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.282	0.953	axial cellular bud site selection	d.129.2	Phosphoglucomutase, C-terminal domain
View	Download	0.281	0.953	axial cellular bud site selection	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.280	0.953	axial cellular bud site selection	c.30.1	PreATP-grasp domain
View	Download	0.279	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.276	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.276	0.953	axial cellular bud site selection	d.129.1	TATA-box binding protein-like
View	Download	0.270	0.953	axial cellular bud site selection	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.269	0.953	axial cellular bud site selection	d.110.2	GAF domain-like
View	Download	0.264	0.953	axial cellular bud site selection	b.11.1	gamma-Crystallin-like
View	Download	0.261	0.953	axial cellular bud site selection	a.24.17	Group V grass pollen allergen
View	Download	0.257	0.953	axial cellular bud site selection	d.122.1	ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View	Download	0.256	0.953	axial cellular bud site selection	d.155.1	Pyruvoyl-dependent histidine and arginine decarboxylases
View	Download	0.256	0.953	axial cellular bud site selection	d.108.1	Acyl-CoA N-acyltransferases (Nat)
View	Download	0.254	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.252	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.250	0.953	axial cellular bud site selection	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.250	0.953	axial cellular bud site selection	b.60.1	Lipocalins
View	Download	0.247	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.242	0.953	axial cellular bud site selection	c.52.1	Restriction endonuclease-like
View	Download	0.241	0.953	axial cellular bud site selection	b.60.1	Lipocalins
View	Download	0.237	0.953	axial cellular bud site selection	f.14.1	Voltage-gated potassium channels
View	Download	0.233	0.953	axial cellular bud site selection	d.110.2	GAF domain-like
View	Download	0.232	0.953	axial cellular bud site selection	b.40.1	Staphylococcal nuclease
View	Download	0.232	0.953	axial cellular bud site selection	d.129.4	Cell-division protein ZipA, C-terminal domain
View	Download	0.231	0.953	axial cellular bud site selection	d.109.1	Actin depolymerizing proteins
View	Download	0.231	0.953	axial cellular bud site selection	d.129.1	TATA-box binding protein-like
View	Download	0.231	0.953	axial cellular bud site selection	d.58.48	MTH1187-like
View	Download	0.230	0.953	axial cellular bud site selection	c.25.1	Ferredoxin reductase-like, C-terminal NADP-linked domain
View	Download	0.229	0.953	axial cellular bud site selection	a.118.9	ENTH/VHS domain
View	Download	0.229	0.953	axial cellular bud site selection	b.60.1	Lipocalins
View	Download	0.228	0.953	axial cellular bud site selection	b.101.1	Ribonuclease domain of colicin E3
View	Download	0.219	0.953	axial cellular bud site selection	d.155.1	Pyruvoyl-dependent histidine and arginine decarboxylases
View	Download	0.218	0.953	axial cellular bud site selection	d.134.1	Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View	Download	0.216	0.953	axial cellular bud site selection	d.91.1	N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
View	Download	0.211	0.953	axial cellular bud site selection	d.110.4	SNARE-like
View	Download	0.210	0.953	axial cellular bud site selection	d.109.1	Actin depolymerizing proteins
View	Download	0.208	0.953	axial cellular bud site selection	c.47.2	RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View	Download	0.208	0.953	axial cellular bud site selection	a.118.1	ARM repeat
View	Download	0.208	0.953	axial cellular bud site selection	d.134.1	Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View	Download	0.205	0.953	axial cellular bud site selection	c.58.1	Aminoacid dehydrogenase-like, N-terminal domain
View	Download	0.201	0.953	axial cellular bud site selection	d.60.1	Probable bacterial effector-binding domain

Predicted Domain #6

Region A:
Residues: [921-1037]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSVLLKKFSK GKILELEIHA KIPEKRLYEG LHKLLEGWKQ YGLKNLVFNI TNMIITGKLV  60
   61 NDSILFLRST LFEIMVLPNG DGRSLIKFNK KTGSTKTLTK LATEIQIILQ KEGVLDK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.846	d.110.1	Profilin (actin-binding protein)
View	Download	0.837	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.702	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.650	c.51.1	Anticodon-binding domain of Class II aaRS
View	Download	0.623	d.129.2	Phosphoglucomutase, C-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits