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View Structure Prediction Details

Protein: HPC2
Organism: Saccharomyces cerevisiae
Length: 623 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPC2.

Description E-value Query
Range
Subject
Range
NFH_MOUSE - (P19246) Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polype...
3.0E-52 [6..589] [481..1073]
gi|16554449, gi|... - gi|16554449|ref|NP_003377.1| zonadhesin isoform 3 [Homo sapiens], gi|12667414|gb|AAK01433.1|AF332977...
8.0E-49 [32..489] [547..1003]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-48 [11..590] [1..589]
gi|8163674 - gi|8163674|gb|AAF73795.1|AF154026_1 surface protein PspC [Streptococcus pneumoniae]
3.0E-48 [102..570] [42..479]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIAIVLDNSK SGSKQTKSSG KMQTQTDTNA EVLNTDNSIK KETGSDSEDL FNKFSNKKTN  60
   61 RKIPNIAEEL AKNRNYVKGA SP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [83-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIIISGSSS TSPSGPSSSS TNPMGIPTNR FNKNTVELYQ HSPSPVMTTN KTDTEEKRQN  60
   61 NRNMDNKNTP ERGSSSFAAK QLKISSLLTI SSNEDSKTLH INDTNGNKNS NAASNNIPSA 120
  121 YAELHTEGNS IESLIKPPSS PRNKSLTPKV ILPTQNMDGT IAKDPHLGDN TPGILIAKTS 180
  181 SPVNLDVEST AQSLGKFNKS TNSLKAALTK APAEKVSLKR SISSVTNSDS NISSSKKPTS 240
  241 EKAKKSSSAS AILPKPTTTK TSKKAASNSS DSTRKKNASN KTTSAIKKES NAGSKLNTVK 300
  301 KENSSLSSIK ATEKEKDKGG NSTEAK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.11
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [409-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSTSNVRKEP TAKSPKRLVA APTVSPPKIL QTAETKAKEP SILIDVPLYQ ADTNDYLDEN  60
   61 GQVIFNLSTL IKEKYHPKSK ELAQLKDSKR NLLMQLSDHS NGSLEKEKDE EGDVIELDDD 120
  121 EDMEEDEGEI DTETNTVTTT ISPKKKSHPM KGKNLIGKYD VEDPFIDDSE LLWEEQRAAT 180
  181 KDGFFVYFGP LIEKGHYASL ERANGTMKRG GVKNK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle