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View Structure Prediction Details

Protein: KTR4
Organism: Saccharomyces cerevisiae
Length: 464 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KTR4.

Description E-value Query
Range
Subject
Range
KTR4_YEAST - Probable mannosyltransferase KTR4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KTR4 P...
KTR4 - Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltran...
0.0 [1..464] [1..464]
KRE2_CANAL - Glycolipid 2-alpha-mannosyltransferase OS=Candida albicans GN=KRE2 PE=3 SV=1
gi|238880609 - gi|238880609|gb|EEQ44247.1| alpha-1,2 mannosyltransferase KTR1 [Candida albicans WO-1]
MNT1_CANAL - Glycolipid 2-alpha-mannosyltransferase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MNT1...
0.0 [123..445] [99..411]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..444] [6..441]
gi|85100333 - gi|85100333|ref|XP_960945.1| hypothetical protein NCU01388 [Neurospora crassa OR74A]
gi|11595646, gi|... - gi|32412802|ref|XP_326881.1| probable alpha-1, 2-mannosyltransferase [MIPS] [Neurospora crassa], gi|...
0.0 [111..454] [47..389]

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Predicted Domain #1
Region A:
Residues: [1-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLSKRILK PVLSVIILIS IAVTVVLYFL TANENYLQAV KDSAKSQYAS LRESYKSITG  60
   61 KTESADELPD HDAEVLDSIM DRLHEPLYEK DTFDPNEVLA ENKQLYEEFL LQEISEPKVD 120
  121 NLVRSGDPLA GKAKGTILSL VRNSDLEDII SSIQQLEEEY NKNFGYPYTF LNDEEFTDEF 180
  181 KDGIKSILPK DRVVEFGTIG PDNWNMPDSI DRERYDQEMD KMSKENIQYA EVESYHNMCR 240
  241 FYSKEFYHHP LLSKYKYVWR LEPNVNFYCK INYDVFQFMN KNDKIYGFVL NLYDSPQTIE 300
  301 TLWTSTMDFV EEHPNYLNVN GAFAWLKDNS QNPKNYDYTQ GYSTCHFWTN FEIVDLDFLR 360
  361 SEPYEKYMQY LEEKGGFYYE RWGDAPVRSL ALALFADKSS IHWFRDIGYH HTPYTNCPTC 420
  421 PADSDRCNGN CVPGKFTPWS DLDNQNCQAT WIRHSMSEEE LEMY

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 222.142668
Match: PF01793
Description: Glycolipid 2-alpha-mannosyltransferase

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.822 N/A N/A a.112.1 Description not found.
View Download 0.770 N/A N/A a.130.1 Chorismate mutase II
View Download 0.721 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.680 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.677 N/A N/A a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain

Predicted Domain #2
Region A:
Residues: [116-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPKVDNLVRS GDPLAGKAKG TILSLVRNSD LEDIISSIQQ LEEEYNKNFG YPYTFLNDEE  60
   61 FTDEFKDGIK SILPKDRVVE FGTIGPDNWN MPDSIDRERY DQEMDKMSKE NIQYAEVESY 120
  121 HNMCRFYSKE FYHHPLLSKY KYVWRLEPNV NFYCKINYDV FQFMNKNDKI YGFVLNLYDS 180
  181 PQTIETLWTS TMDFVEEHPN YLNVNGAFAW LKDNSQNPKN YDYTQGYSTC HFWTNFEIVD 240
  241 LDFLRSEPYE KYMQYLEEKG GFYYERWGDA PVRSLALALF ADKSSIHWFR DIGYHHTPYT 300
  301 NCPTCPADSD RCNGNCVPGK FTPWSDLDNQ NCQATWIRHS MSEEELEMY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 148.0
Match: 1s4nA
Description: Crystal structure of yeast alpha1,2-mannosyltransferase Kre2p/Mnt1p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyltransferase activity 5.57855076532185 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 4.49413422196176 bayes_pls_golite062009
UDP-glycosyltransferase activity 4.08451171179562 bayes_pls_golite062009
alpha-1,2-mannosyltransferase activity 3.80392076707564 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 3.4614674054855 bayes_pls_golite062009
transferase activity 3.32517438937547 bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity 3.19923094610567 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.60650378115696 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.51696952719873 bayes_pls_golite062009
catalytic activity 1.88676710996045 bayes_pls_golite062009
nucleotidyltransferase activity 1.86990263440735 bayes_pls_golite062009
uridylyltransferase activity 1.27888067902271 bayes_pls_golite062009
binding 0.948692623641759 bayes_pls_golite062009
glucuronosyltransferase activity 0.36353543999278 bayes_pls_golite062009
protein binding 0.124656890356575 bayes_pls_golite062009
UDP-galactosyltransferase activity 0.10185872015123 bayes_pls_golite062009
galactosyltransferase activity 0.0931461042017721 bayes_pls_golite062009
alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity 0.0339369954475406 bayes_pls_golite062009
acetylglucosaminyltransferase activity 0.0278258721775009 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle