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View Structure Prediction Details

Protein: TPS1
Organism: Saccharomyces cerevisiae
Length: 495 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPS1.

Description E-value Query
Range
Subject
Range
gi|3540 - gi|3540|emb|CAA43580.1| cif1 [Saccharomyces cerevisiae]
0.0 [1..495] [1..495]
TPS1_KLULA - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit OS=Kluyveromyces lactis GN=TPS...
TPS1_KLULA - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit OS=Kluyveromyces lactis (strai...
0.0 [3..487] [2..487]
TPSB_ASPNG - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 OS=Aspergillus niger GN=tpsB PE=3 SV=1
gi|145238596 - gi|145238596|ref|XP_001391945.1| alpha, alpha-trehalose-phosphate synthase (UDP-forming) 2 (trehalos...
0.0 [10..482] [6..477]
TPS1_ZYGRO - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Zygosaccharomyces rouxii GN=TPS1 PE=2 SV=1
0.0 [1..481] [1..476]
TPS1_SCHPO - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Schizosaccharomyces pombe (strain 972 / AT...
tps1 - alpha,alpha-trehalose-phosphate synthase [UDP-forming]
0.0 [11..483] [14..484]
TPS1_EMENI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Emericella nidulans GN=tpsA PE=3 SV=1
TPS1_EMENI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Emericella nidulans (strain FGSC A4 / ATCC...
0.0 [9..494] [5..488]
TPS1_YARLI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Yarrowia lipolytica GN=TPS1 PE=2 SV=1
TPS1_YARLI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Yarrowia lipolytica (strain CLIB 122 / E 1...
0.0 [15..482] [1..468]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDNAKAQL TSSSGGNIIV VSNRLPVTIT KNSSTGQYEY AMSSGGLVTA LEGLKKTYTF  60
   61 KWFGWPGLEI PDDEKDQVRK DLLEKFNAVP IFLSDEIADL HYNGFSNSIL WPLFH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 11.2045941324603 bayes_pls_golite062009
glucosyltransferase activity 8.25064561355471 bayes_pls_golite062009
UDP-glucosyltransferase activity 8.0463972704113 bayes_pls_golite062009
trehalose-phosphatase activity 7.58500038184065 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
transferase activity 2.18054407163329 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 1.55280519670033 bayes_pls_golite062009
carbohydrate phosphatase activity 0.78952375993773 bayes_pls_golite062009
glycogen phosphorylase activity 0.607220464589157 bayes_pls_golite062009
binding 0.345236672370351 bayes_pls_golite062009
phosphorylase activity 0.296436712681472 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009
protein binding 0.198267161626932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [116-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHPGEINFDE NAWLAYNEAN QTFTNEIAKT MNHNDLIWVH DYHLMLVPEM LRVKIHEKQL  60
   61 QNVKVGWFLH TPFPSSEIYR ILPVRQEILK GVLSCDLVGF HTYDYARHFL SSVQRVLNVN 120
  121 TLPNGVEYQG RFVNVGAFPI GIDVDKFT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [463-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YISKYTSAFW GENFVHELYS TSSSSTSSSA TKN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.21
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [264-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGLKKESVQK RIQQLKETFK GCKIIVGVDR LDYIKGVPQK LHAMEVFLNE HPEWRGKVVL  60
   61 VQVAVPSRGD VEEYQYLRSV VNELVGRING QFGTVEFVPI HFMHKSIPFE ELISLYAVSD 120
  121 VCLVSSTRDG MNLVSYEYIA CQEEKKGSLI LSEFTGAAQS LNGAIIVNPW NTDDLSDAIN 180
  181 EALTLPDVKK EVNWEKLYK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.21
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle