YRC Public Data Repository - Protein Structure Prediction

Protein:	YSA1
Organism:	Saccharomyces cerevisiae
Length:	231 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YSA1.

Description	E-value	Query Range	Subject Range
YSA1 - Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl... ADPP_YEAST - ADP-ribose pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YSA1 PE=1 SV=...	1.0E-48	[1..231]	[1..231]
NUDT5_MOUSE - ADP-sugar pyrophosphatase OS=Mus musculus GN=Nudt5 PE=1 SV=1	3.0E-32	[13..225]	[2..206]
gi\|60655443 - gi\|60655443\|gb\|AAX32285.1\| nudix-type motif 5 [synthetic construct] NUDT5 - nudix (nucleoside diphosphate linked moiety X)-type motif 5	5.0E-32	[35..225]	[17..207]
gi\|15643937, gi\|... - gi\|4981730\|gb\|AAD36256.1\|AE001774_13 conserved hypothetical protein [Thermotoga maritima MSB8], gi\|1... gi\|7445034 - pir\|\|H72286 conserved hypothetical protein - Thermotoga maritima (strain MSB8)	3.0E-31	[31..226]	[3..175]
ADPP_BACSU - ADP-ribose pyrophosphatase OS=Bacillus subtilis GN=nudF PE=1 SV=1 ADPP_BACSU - ADP-ribose pyrophosphatase OS=Bacillus subtilis (strain 168) GN=nudF PE=1 SV=1 gi\|221323801 - gi\|221323801\|ref\|ZP_03605095.1\| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. S... gi\|221319525 - gi\|221319525\|ref\|ZP_03600819.1\| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. J... gi\|221314602 - gi\|221314602\|ref\|ZP_03596407.1\| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. N...	1.0E-29	[31..224]	[4..177]
gi\|18310792, gi\|... - gi\|18310792\|ref\|NP_562726.1\| hypothetical protein CPE1810 [Clostridium perfringens str. 13], gi\|1814...	2.0E-29	[30..223]	[2..173]
gi\|25303385 - pir\|\|C89929 conserved hypothetical protein SA1330 [imported] - Staphylococcus aureus (strain N315) gi\|269203126\|ref... - MutT/nudix family protein [Staphylococcus aureus subsp. aureus ED98] gi\|253314867 - gi\|253314867\|ref\|ZP_04838080.1\| hypothetical protein SauraC_01580 [Staphylococcus aureus subsp. aure... gi\|255006285 - gi\|255006285\|ref\|ZP_05144886.2\| hypothetical protein SauraM_07450 [Staphylococcus aureus subsp. aure... gi\|156721953, gi... - gi\|156979818\|ref\|YP_001442077.1\| hypothetical protein SAHV_1487 [Staphylococcus aureus subsp. aureus... gi\|90428641, gi\|... - gi\|90582276\|ref\|ZP_01238040.1\| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH1], gi\|9042864... gi\|15924489, gi\|... - gi\|15924489\|ref\|NP_372023.1\| ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureus Mu50], ... gi\|90585117, gi\|... - gi\|90585117\|ref\|ZP_01240828.1\| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH9], gi\|9043124... gi\|15927080, gi\|... - gi\|15927080\|ref\|NP_374613.1\| hypothetical protein SA1330 [Staphylococcus aureus subsp. aureus N315],...	7.0E-29	[30..224]	[2..174]
SPBP35G2.12 - nucleoside diphosphate-sugar hydrolase YN8C_SCHPO - Uncharacterized Nudix hydrolase P35G2.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=S...	1.0E-28	[27..228]	[1..202]

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Predicted Domain #1

Region A:
Residues: [1-72]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLRNVRVIS LNSRRLFRTM STVKGKPEDA KIIEARHVKE TSDCKWIGLQ KIIYKDPNGK  60
   61 EREWDSAVRT TR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.891	d.17.2	Copper amine oxidase, domains 1 and 2

Predicted Domain #2

Region A:
Residues: [73-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGGVDGIGI LTILKYKDGK PDEILLQKQF RPPVEGVCIE MPAGLIDAGE DIDTAALREL  60
   61 KEETGYSGKI ISKSPTVFND PGFTNTNLCL VTVEVDMSLP ENQKPVTQLE DNEFIECFSV 120
  121 ELHKFPDEMV KLDQQGYKLD ARVQNVAQGI LMAKQYHIK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.40824
Match:	1f3yA_
Description:	Diadenosine tetraphosphate hydrolase (Ap4A hydrolase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits