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View Structure Prediction Details

Protein: YSA1
Organism: Saccharomyces cerevisiae
Length: 231 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YSA1.

Description E-value Query
Range
Subject
Range
YSA1 - Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl...
ADPP_YEAST - ADP-ribose pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YSA1 PE=1 SV=...
1.0E-48 [1..231] [1..231]
NUDT5_MOUSE - ADP-sugar pyrophosphatase OS=Mus musculus GN=Nudt5 PE=1 SV=1
3.0E-32 [13..225] [2..206]
gi|60655443 - gi|60655443|gb|AAX32285.1| nudix-type motif 5 [synthetic construct]
NUDT5 - nudix (nucleoside diphosphate linked moiety X)-type motif 5
5.0E-32 [35..225] [17..207]
gi|15643937, gi|... - gi|4981730|gb|AAD36256.1|AE001774_13 conserved hypothetical protein [Thermotoga maritima MSB8], gi|1...
gi|7445034 - pir||H72286 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
3.0E-31 [31..226] [3..175]
ADPP_BACSU - ADP-ribose pyrophosphatase OS=Bacillus subtilis GN=nudF PE=1 SV=1
ADPP_BACSU - ADP-ribose pyrophosphatase OS=Bacillus subtilis (strain 168) GN=nudF PE=1 SV=1
gi|221323801 - gi|221323801|ref|ZP_03605095.1| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. S...
gi|221319525 - gi|221319525|ref|ZP_03600819.1| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. J...
gi|221314602 - gi|221314602|ref|ZP_03596407.1| ADP-ribose pyrophosphatase [Bacillus subtilis subsp. subtilis str. N...
1.0E-29 [31..224] [4..177]
gi|18310792, gi|... - gi|18310792|ref|NP_562726.1| hypothetical protein CPE1810 [Clostridium perfringens str. 13], gi|1814...
2.0E-29 [30..223] [2..173]
gi|25303385 - pir||C89929 conserved hypothetical protein SA1330 [imported] - Staphylococcus aureus (strain N315)
gi|269203126|ref... - MutT/nudix family protein [Staphylococcus aureus subsp. aureus ED98]
gi|253314867 - gi|253314867|ref|ZP_04838080.1| hypothetical protein SauraC_01580 [Staphylococcus aureus subsp. aure...
gi|255006285 - gi|255006285|ref|ZP_05144886.2| hypothetical protein SauraM_07450 [Staphylococcus aureus subsp. aure...
gi|156721953, gi... - gi|156979818|ref|YP_001442077.1| hypothetical protein SAHV_1487 [Staphylococcus aureus subsp. aureus...
gi|90428641, gi|... - gi|90582276|ref|ZP_01238040.1| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH1], gi|9042864...
gi|15924489, gi|... - gi|15924489|ref|NP_372023.1| ADP-ribose pyrophosphatase [Staphylococcus aureus subsp. aureus Mu50], ...
gi|90585117, gi|... - gi|90585117|ref|ZP_01240828.1| NUDIX hydrolase [Staphylococcus aureus subsp. aureus JH9], gi|9043124...
gi|15927080, gi|... - gi|15927080|ref|NP_374613.1| hypothetical protein SA1330 [Staphylococcus aureus subsp. aureus N315],...
7.0E-29 [30..224] [2..174]
SPBP35G2.12 - nucleoside diphosphate-sugar hydrolase
YN8C_SCHPO - Uncharacterized Nudix hydrolase P35G2.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=S...
1.0E-28 [27..228] [1..202]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLRNVRVIS LNSRRLFRTM STVKGKPEDA KIIEARHVKE TSDCKWIGLQ KIIYKDPNGK  60
   61 EREWDSAVRT TR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.849 b.34.5 Translation proteins SH3-like domain
View Download 0.823 d.17.1 Cystatin/monellin
View Download 0.891 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.890 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.821 b.1.1 Immunoglobulin
View Download 0.819 b.1.1 Immunoglobulin
View Download 0.800 b.1.1 Immunoglobulin
View Download 0.796 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.765 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.758 b.1.2 Fibronectin type III
View Download 0.755 d.230.2 Flavin-binding protein dodecin
View Download 0.754 d.230.2 Flavin-binding protein dodecin
View Download 0.739 b.1.3 PKD domain
View Download 0.715 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.714 b.1.3 PKD domain
View Download 0.710 b.1.1 Immunoglobulin
View Download 0.684 d.17.5 Uracil-DNA glycosylase inhibitor protein
View Download 0.669 b.1.1 Immunoglobulin
View Download 0.665 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.655 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.654 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.650 d.58.13 Anticodon-binding domain of PheRS
View Download 0.649 b.34.5 Translation proteins SH3-like domain
View Download 0.647 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.647 b.34.5 Translation proteins SH3-like domain
View Download 0.644 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.642 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.640 d.17.1 Cystatin/monellin
View Download 0.632 g.18.1 Complement control module/SCR domain
View Download 0.630 b.1.2 Fibronectin type III
View Download 0.628 b.34.5 Translation proteins SH3-like domain
View Download 0.627 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.625 b.1.1 Immunoglobulin
View Download 0.614 b.1.1 Immunoglobulin
View Download 0.610 d.230.2 Flavin-binding protein dodecin
View Download 0.609 b.61.1 Avidin/streptavidin
View Download 0.599 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.598 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.592 d.17.1 Cystatin/monellin
View Download 0.582 b.1.1 Immunoglobulin
View Download 0.571 d.17.1 Cystatin/monellin
View Download 0.569 b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.568 d.17.1 Cystatin/monellin
View Download 0.568 b.1.1 Immunoglobulin
View Download 0.552 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.550 b.1.18 E set domains
View Download 0.549 b.1.2 Fibronectin type III
View Download 0.547 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.547 b.61.1 Avidin/streptavidin
View Download 0.541 b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.537 d.17.4 NTF2-like
View Download 0.537 d.17.1 Cystatin/monellin
View Download 0.536 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.534 d.50.1 dsRNA-binding domain-like
View Download 0.527 d.58.8 Viral DNA-binding domain
View Download 0.525 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.524 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.522 b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.516 g.18.1 Complement control module/SCR domain
View Download 0.511 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.509 b.7.2 Periplasmic chaperone C-domain
View Download 0.505 b.4.1 HSP40/DnaJ peptide-binding domain
View Download 0.504 b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.502 b.1.1 Immunoglobulin
View Download 0.484 b.38.1 Sm-like ribonucleoproteins
View Download 0.483 d.29.1 Ribosomal protein L31e
View Download 0.466 d.17.1 Cystatin/monellin
View Download 0.464 b.1.1 Immunoglobulin
View Download 0.460 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.456 b.105.1 Penicillin-binding protein 5, C-terminal domain
View Download 0.451 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.446 b.1.2 Fibronectin type III
View Download 0.440 d.58.8 Viral DNA-binding domain
View Download 0.439 g.18.1 Complement control module/SCR domain
View Download 0.435 b.1.18 E set domains
View Download 0.433 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.430 d.200.1 Integrin beta tail domain
View Download 0.428 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.422 b.34.4 Electron transport accessory proteins
View Download 0.418 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.418 d.15.2 CAD & PB1 domains
View Download 0.414 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.414 d.71.1 Cell division protein MinE topological specificity domain
View Download 0.410 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.410 b.7.2 Periplasmic chaperone C-domain
View Download 0.403 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.402 b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.389 b.36.1 PDZ domain-like
View Download 0.378 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.377 d.17.1 Cystatin/monellin
View Download 0.375 d.17.1 Cystatin/monellin
View Download 0.372 b.1.3 PKD domain
View Download 0.369 b.34.5 Translation proteins SH3-like domain
View Download 0.369 b.1.14 Invasin/intimin cell-adhesion fragments
View Download 0.369 d.58.7 RNA-binding domain, RBD
View Download 0.363 b.1.3 PKD domain
View Download 0.361 b.1.2 Fibronectin type III
View Download 0.353 b.61.1 Avidin/streptavidin
View Download 0.351 b.7.3 PHL pollen allergen
View Download 0.350 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.337 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.336 b.36.1 PDZ domain-like
View Download 0.332 b.1.2 Fibronectin type III
View Download 0.326 d.99.1 Ribosomal protein L9 C-domain
View Download 0.323 b.1.1 Immunoglobulin
View Download 0.322 d.99.1 Ribosomal protein L9 C-domain
View Download 0.316 d.58.13 Anticodon-binding domain of PheRS
View Download 0.316 d.52.4 YhbC-like, N-terminal domain
View Download 0.313 d.93.1 SH2 domain
View Download 0.312 b.1.2 Fibronectin type III
View Download 0.311 b.34.7 DNA-binding domain of retroviral integrase
View Download 0.309 d.17.1 Cystatin/monellin
View Download 0.306 b.1.3 PKD domain
View Download 0.305 d.93.1 SH2 domain
View Download 0.305 b.7.3 PHL pollen allergen
View Download 0.301 b.1.1 Immunoglobulin
View Download 0.300 d.58.12 eEF-1beta-like
View Download 0.297 b.1.1 Immunoglobulin
View Download 0.295 b.7.3 PHL pollen allergen
View Download 0.291 b.1.18 E set domains
View Download 0.287 b.7.3 PHL pollen allergen
View Download 0.286 b.1.2 Fibronectin type III
View Download 0.281 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.281 b.1.2 Fibronectin type III
View Download 0.277 b.1.2 Fibronectin type III
View Download 0.276 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.275 d.17.1 Cystatin/monellin
View Download 0.273 d.58.5 GlnB-like
View Download 0.273 d.58.13 Anticodon-binding domain of PheRS
View Download 0.272 b.36.1 PDZ domain-like
View Download 0.271 d.58.12 eEF-1beta-like
View Download 0.271 d.17.1 Cystatin/monellin
View Download 0.268 b.61.1 Avidin/streptavidin
View Download 0.266 b.7.3 PHL pollen allergen
View Download 0.265 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.263 d.53.1 Ribosomal protein S3 C-terminal domain
View Download 0.263 b.61.1 Avidin/streptavidin
View Download 0.261 d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.260 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.259 d.12.1 Ribosomal proteins L23 and L15e
View Download 0.257 d.99.1 Ribosomal protein L9 C-domain
View Download 0.256 b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.254 b.1.1 Immunoglobulin
View Download 0.250 d.50.1 dsRNA-binding domain-like
View Download 0.248 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.247 b.1.6 Cadherin
View Download 0.245 d.93.1 SH2 domain
View Download 0.244 b.1.2 Fibronectin type III
View Download 0.243 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.243 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.242 d.17.1 Cystatin/monellin
View Download 0.237 b.43.4 Riboflavin synthase domain-like
View Download 0.233 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.232 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.230 d.110.3 PYP-like sensor domain (PAS domain)
View Download 0.221 b.36.1 PDZ domain-like
View Download 0.217 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.217 d.17.1 Cystatin/monellin
View Download 0.216 b.50.1 Acid proteases
View Download 0.212 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.212 d.99.1 Ribosomal protein L9 C-domain
View Download 0.209 d.17.4 NTF2-like
View Download 0.208 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.205 d.12.1 Ribosomal proteins L23 and L15e
View Download 0.204 b.61.5 Dipeptidyl peptidase I (cathepsin C), exclusion domain
View Download 0.204 b.61.1 Avidin/streptavidin
View Download 0.201 d.74.3 RBP11-like subunits of RNA polymerase

Predicted Domain #2
Region A:
Residues: [73-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGGVDGIGI LTILKYKDGK PDEILLQKQF RPPVEGVCIE MPAGLIDAGE DIDTAALREL  60
   61 KEETGYSGKI ISKSPTVFND PGFTNTNLCL VTVEVDMSLP ENQKPVTQLE DNEFIECFSV 120
  121 ELHKFPDEMV KLDQQGYKLD ARVQNVAQGI LMAKQYHIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.40824
Match: 1f3yA_
Description: Diadenosine tetraphosphate hydrolase (Ap4A hydrolase)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle