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View Structure Prediction Details

Protein: EXO84
Organism: Saccharomyces cerevisiae
Length: 753 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EXO84.

Description E-value Query
Range
Subject
Range
gi|190408739 - gi|190408739|gb|EDV12004.1| exocyst complex component EXO84 [Saccharomyces cerevisiae RM11-1a]
EXO84_YEAST - Exocyst complex component EXO84 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EXO84 PE...
EXO84 - Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p...
gi|151946494 - gi|151946494|gb|EDN64716.1| exocyst complex component [Saccharomyces cerevisiae YJM789]
0.0 [1..753] [1..753]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [168..748] [4..541]
SPAC6F12.08c - exocyst complex subunit Exo84
gi|19114206 - gi|19114206|ref|NP_593294.1| hypothetical protein SPAC6F12.08c [Schizosaccharomyces pombe 972h-]
0.0 [111..744] [4..569]
exo84-PA - This gene is referred to in FlyBase by the symbol Dmel\exo84 (CG6095, FBgn0260946). It is a protein_...
0.0 [175..745] [2..493]
gi|27754564, gi|... - gi|28393871|gb|AAO42343.1| unknown protein [Arabidopsis thaliana], gi|27754564|gb|AAO22729.1| unknow...
2.0E-67 [449..737] [38..337]

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Predicted Domain #1
Region A:
Residues: [1-157]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEFSLKKAR NNWKHVKKSA SSPAKQKTPP SPAKPKQKTK KNPYSDLKDP ATSYTLPTIN  60
   61 ARERSRVATS MQRRLSIHNT NYAPPTLDYS MPLPDMPNMI VPNDNVDSSH NNSSFTTENE 120
  121 SVSSKGPSNS LNLSTADLSL NDSSYNKVPA RSAMRNT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [158-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNPSGSNDPF NNSTSLRKML ANPHFNAKDF VHDKLGNASA ITIDKFTSNL TDLSIQVQEE  60
   61 VKLNINKSYN EIMTVNNDLN VAMLELKRVR ANINDLNEVL DQCTKIAEKR LQLQDQIDQE 120
  121 RQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.801 0.212 spliceosome assembly a.25.1 Ferritin-like
View Download 0.732 0.050 spliceosome assembly a.24.3 Cytochromes
View Download 0.818 0.043 spliceosome assembly a.7.1 Spectrin repeat
View Download 0.769 0.012 spliceosome assembly a.2.6 Effector domain of the protein kinase pkn/prk1
View Download 0.724 0.005 spliceosome assembly f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.824 N/A N/A a.7.8 GAT domain
View Download 0.820 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.735 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.720 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.712 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.709 N/A N/A a.7.1 Spectrin repeat
View Download 0.676 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.645 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.645 N/A N/A a.63.1 Apolipophorin-III
View Download 0.623 N/A N/A a.46.1 Methionine synthase domain
View Download 0.598 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.575 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.548 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.537 N/A N/A a.47.2 t-snare proteins
View Download 0.533 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.499 N/A N/A a.29.2 Bromodomain
View Download 0.491 N/A N/A a.29.2 Bromodomain
View Download 0.477 N/A N/A a.118.1 ARM repeat
View Download 0.459 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.450 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.447 N/A N/A a.2.7 tRNA-binding arm
View Download 0.440 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.437 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.428 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.425 N/A N/A a.47.2 t-snare proteins
View Download 0.420 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.414 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.403 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.402 N/A N/A a.2.7 tRNA-binding arm
View Download 0.401 N/A N/A a.26.1 4-helical cytokines
View Download 0.384 N/A N/A a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.377 N/A N/A f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.369 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.367 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.366 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.361 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.360 N/A N/A a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.360 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.357 N/A N/A a.25.1 Ferritin-like
View Download 0.354 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.353 N/A N/A a.26.1 4-helical cytokines
View Download 0.352 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.348 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.348 N/A N/A a.19.1 Fertilization protein
View Download 0.341 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.338 N/A N/A d.198.2 Arp2/3 complex subunits
View Download 0.336 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.336 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.333 N/A N/A a.24.3 Cytochromes
View Download 0.328 N/A N/A a.87.1 DBL homology domain (DH-domain)
View Download 0.323 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.322 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.320 N/A N/A a.24.4 Hemerythrin
View Download 0.318 N/A N/A a.29.2 Bromodomain
View Download 0.310 N/A N/A a.24.1 Apolipoprotein
View Download 0.305 N/A N/A a.166.1 RuBisCo LSMT C-terminal, substrate-binding domain
View Download 0.304 N/A N/A a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.302 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.302 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.297 N/A N/A a.25.1 Ferritin-like
View Download 0.290 N/A N/A d.224.1 SufE-like
View Download 0.288 N/A N/A f.15.1 Small-conductance potassium channel
View Download 0.288 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.286 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.283 N/A N/A a.7.1 Spectrin repeat
View Download 0.280 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.277 N/A N/A a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.272 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.270 N/A N/A a.7.8 GAT domain
View Download 0.264 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.264 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.260 N/A N/A a.2.7 tRNA-binding arm
View Download 0.259 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.258 N/A N/A d.224.1 SufE-like
View Download 0.257 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.252 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.251 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.249 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.249 N/A N/A a.118.8 TPR-like
View Download 0.242 N/A N/A d.25.1 Acidic mitochondrial matrix protein p32
View Download 0.241 N/A N/A a.7.7 BAG domain
View Download 0.238 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.236 N/A N/A a.118.8 TPR-like
View Download 0.232 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.232 N/A N/A a.2.5 Prefoldin
View Download 0.230 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.228 N/A N/A a.47.2 t-snare proteins
View Download 0.224 N/A N/A a.2.3 Chaperone J-domain
View Download 0.222 N/A N/A a.26.1 4-helical cytokines
View Download 0.220 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.215 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.212 N/A N/A a.79.1 Antitermination factor NusB
View Download 0.212 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.209 N/A N/A a.182.1 GatB/YqeY domain
View Download 0.206 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.201 N/A N/A a.74.1 Cyclin-like
View Download 0.201 N/A N/A a.1.1 Globin-like

Predicted Domain #3
Region A:
Residues: [280-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNFNNVESHS NSPALLPPLK AGQNGNLMRR DRSSVLILEK FWDTELDQLF KNVEGAQKFI  60
   61 NS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.413 a.4.1 Homeodomain-like
View Download 0.626 d.58.17 Metal-binding domain
View Download 0.526 d.186.1 Head-to-tail joining protein W, gpW
View Download 0.454 d.58.17 Metal-binding domain
View Download 0.418 d.58.17 Metal-binding domain
View Download 0.375 d.58.1 4Fe-4S ferredoxins
View Download 0.371 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.343 d.186.1 Head-to-tail joining protein W, gpW
View Download 0.316 a.4.1 Homeodomain-like
View Download 0.306 a.60.2 RuvA domain 2-like
View Download 0.298 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.286 d.9.1 Interleukin 8-like chemokines
View Download 0.283 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.275 a.60.8 HRDC-like
View Download 0.275 d.58.5 GlnB-like
View Download 0.275 g.41.10 Zn-finger domain of Sec23/24
View Download 0.265 b.40.4 Nucleic acid-binding proteins
View Download 0.257 d.74.2 C-terminal domain of arginine repressor
View Download 0.255 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.240 d.52.1 Alpha-lytic protease prodomain
View Download 0.234 b.40.4 Nucleic acid-binding proteins
View Download 0.227 d.15.2 CAD & PB1 domains
View Download 0.220 d.58.8 Viral DNA-binding domain
View Download 0.202 d.93.1 SH2 domain

Predicted Domain #4
Region A:
Residues: [342-480]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKGRHILMNS ANWMELNTTT GKPLQMVQIF ILNDLVLIAD KSRDKQNDFI VSQCYPLKDV  60
   61 TVTQEEFSTK RLLFKFSNSN SSLYECRDAD ECSRLLDVIR KAKDDLCDIF HVEEENSKRI 120
  121 RESFRYLQST QQTPGRENN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 1awe__
Description: Son of sevenless-1 (sos-1)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [481-753]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSPNKNKRRS MGGSITPGRN VTGAMDQYLL QNLTLSMHSR PRSRDMSSTA QRLKFLDEGV  60
   61 EEIDIELARL RFESAVETLL DIESQLEDLS ERISDEELML LNLISLKIEQ RREAISSKLS 120
  121 QSILSSNEIV HLKSGTENMI KLGLPEQALD LFLQNRSNFI QDLILQIGSV DNPTNYLTQL 180
  181 AVIRFQTIKK TVEDFQDIFK ELGAKISSIL VDWCSDEVDN HFKLIDKQLL NDEMLSPGSI 240
  241 KSSRKQIDGL KAVGLDFVYK LDEFIKKNSD KIR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle