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View Structure Prediction Details

Protein: TRM7
Organism: Saccharomyces cerevisiae
Length: 310 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM7.

Description E-value Query
Range		 Subject
Range
TRM7_YEAST - tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 20...
gi|190408775 - gi|190408775|gb|EDV12040.1| tRNA (uridine-2'-O-)-methyltransferase TRM7 [Saccharomyces cerevisiae RM...
gi|207347732 - gi|207347732|gb|EDZ73814.1| YBR061Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151946453 - gi|151946453|gb|EDN64675.1| 2'-O-ribose tRNA anticodon loop methyltransferase [Saccharomyces cerevis...
TRM7 - 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of t...
 6.0E-97 [1..310] [1..310]
gi|3511153, gi|2... - gi|3511153|gb|AAC33734.1| cell division protein [Homo sapiens], gi|29029591|ref|NP_803188.1| FtsJ ho...
 3.0E-87 [1..310] [1..288]
SPAC4F10.03c - 2'-O-ribose methyltransferase
TRM7_SCHPO - Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Schizosaccharomyces pombe (stra...
 2.0E-83 [1..303] [1..281]
CE23932 - status:Confirmed UniProt:Q22031 protein_id:CAA85279.2
 2.0E-82 [1..308] [1..295]
CG7009-PA - This gene is referred to in FlyBase by the symbol Dmel\CG7009 (CG7009, FBgn0038861). It is a protein...
 3.0E-72 [1..300] [1..281]

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Predicted Domain #1
Region A:
Residues: [1-213] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKSSKDKRD LYYRKAKEQG YRARSAFKLL QLNDQFHFLD DPNLKRVVDL CAAPGSWSQV  60
   61 LSRKLFDESP SSDKEDRKIV SVDLQPMSPI PHVTTLQADI THPKTLARIL KLFGNEKADF 120
  121 VCSDGAPDVT GLHDLDEYVQ QQLIMSALQL TACILKKGGT FVAKIFRGRD IDMLYSQLGY 180
  181 LFDKIVCAKP RSSRGTSLEA FIVCLGYNPP SNW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 270.0
Match: 1eizA_
Description: RNA methyltransferase FtsJ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
rRNA methyltransferase activity 4.09362182773099 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein methyltransferase activity 3.92746815303714 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
histone methyltransferase activity 2.99461585647365 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
arginine N-methyltransferase activity 2.41876112831625 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.04296107639729 bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity 1.88889414729709 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 1.83964463328968 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 1.75675289134467 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 1.66871163498737 bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity 1.29759910099835 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.1103522853299 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 1.10713374933008 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 0.89325812193225 bayes_pls_golite062009
DNA binding 0.71058003448013 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.698509190696763 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
binding 0.383237930789959 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 0.364369105571521 bayes_pls_golite062009
O-methyltransferase activity 0.250946859465502 bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity 0.234572322347698 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [214-310] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPKLDVNTSV DEFFQGCFLN KLCISDKLSH WNEEERNIAE FMACGSLQSF DSDATYHDLP  60
   61 SSVAGTSSSL DPVQSPTNPP YKKALELKRS GKLTRSV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.213 0.010 tRNA methyltransferase activity d.39.1 Dynein light chain 8 (DLC8)
View Download 0.213 N/A N/A d.39.1 Dynein light chain 8 (DLC8)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle